Diverse Chemical Libraries from Photosynthetic Marine Microalgae

光合海洋微藻的多种化学文库

• 批准号: 7274184
• 负责人: JEFFREY Lawson Cameron WRIGHT
• 金额: $ 45万
• 依托单位: UNIVERSITY OF NORTH CAROLINA WILMINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7274184
• 关键词: Arts; Award; Biological; Biological Factors; Biological Testing; Biomass; Cataloging; Catalogs; Chemicals; Chromatography; Class; Collection; Condition; Coupled; Deposition; Development; Dinophyceae; Ensure; Evaluation; Event; Family; Growth; Housing; Laboratory Organism; Libraries; Marines; Mass Spectrum Analysis; Methods; Oceans; Organic Chemistry; Organism; Pan Genus; Process; Production; Productivity; Resources; Science; Scientist; Series; Source; Structure; Techniques; Today; Toxin; United States National Institutes of Health; Work; base; chemical resource; desire; instrument; liquid chromatography mass spectrometry; marine organism; member; microorganism; novel; scale up; small molecule libraries

DESCRIPTION (provided by applicant): Marine organisms have proven to be an important resource for new natural products. However, in many cases it is difficult, if not impossible, to ensure a constant supply of material for further biological testing and evaluation. Marine microalgae have been recognized as an important biological resource for new chemical compounds, but they remain underexploited, even today. Indeed, most studies of microalgae have been focused on those species that produce toxins, which represent a small percentage of the total group. However, the presence of toxins, often of unique structure, indicates that the producing organism has the biosynthetic capability to produce other unusual or exotic molecules. However these other non-toxic metabolites may be overlooked, and in addition may only be present in very small amounts. The UNCW Center for Marine Science (CMS) has a unique collection of over 300 clones of microalgae, representing several groups, of which only two species have been investigated by CMS scientists for the compounds they produce. This collection, coupled with the extensive culture scale-up and chemical processing facilities at CMS, ensures an unlimited supply of new chemical compounds. These compounds, as they are obtained, are characterized by the well-equipped structural organic chemistry group located at CMS. The libraries of compounds will be provided to NIH under the conditions of any award. Compounds will be accompanied by certificates of analysis, including structure elucidation. Compounds will be cataloged at CMS to permit re-isolation from cultured sources on a continual or increased basis, as needed.

描述（由申请人提供）：海洋生物已被证明是新天然产品的重要资源。然而，在许多情况下，很难（如果不是不可能的话）确保不断供应材料以供进一步的生物学测试和评价。海洋微藻被认为是新化合物的重要生物资源，但即使在今天，它们仍然没有得到充分开发。事实上，大多数对微藻的研究都集中在那些产生毒素的物种上，它们只占总种群的一小部分。然而，毒素的存在，往往是独特的结构，表明生产生物体具有生物合成能力，以产生其他不寻常的或外来的分子。然而，这些其他无毒代谢物可能会被忽略，而且可能仅以非常少量存在。UNCW海洋科学中心（CMS）拥有300多个微藻克隆的独特收藏，代表了几个群体，其中只有两个物种被CMS科学家研究了它们产生的化合物。这种收集，加上CMS广泛的培养规模和化学加工设施，确保了新化合物的无限供应。这些化合物，因为他们得到的，其特征在于装备精良的结构有机化学组位于CMS。化合物库将在任何奖励条件下提供给NIH。化合物将附有分析证书，包括结构解析。将在CMS对化合物进行编目，以允许根据需要连续或增加从培养来源中重新分离。

项目成果

Absolute configuration of brevisamide and brevisin: confirmation of a universal biosynthetic process for Karenia brevis polyethers.

• DOI: 10.1021/np100159j
• 发表时间: 2010-06-25
• 期刊: Journal of natural products
• 影响因子: 5.1
• 作者: Van Wagoner RM;Satake M;Bourdelais AJ;Baden DG;Wright JL
• 通讯作者: Wright JL

Structure and relative potency of several karlotoxins from Karlodinium veneficum.

• DOI: 10.1021/np100158r
• 发表时间: 2010-08-27
• 期刊: Journal of natural products
• 影响因子: 5.1
• 作者: Van Wagoner RM;Deeds JR;Tatters AO;Place AR;Tomas CR;Wright JL
• 通讯作者: Wright JL

Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum.

• DOI: 10.1016/j.tetlet.2008.08.103
• 发表时间: 2008-11-03
• 期刊: TETRAHEDRON LETTERS
• 影响因子: 1.8
• 作者: Van Wagoner, Ryan M.;Deeds, Jonathan R.;Satake, Masayuki;Ribeiro, Anthony A.;Place, Allen R.;Wright, Jeffrey L. C.
• 通讯作者: Wright, Jeffrey L. C.