Diverse Chemical Libraries:Photosynthetic Marine M*(RMI)

多样化的化学库：光合海洋 M*(RMI)

• 批准号: 7022620
• 负责人: JEFFREY Lawson Cameron WRIGHT
• 金额: $ 45.09万
• 依托单位: UNIVERSITY OF NORTH CAROLINA WILMINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-23 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7022620
• 关键词: algae; aquaculture; aquatic organism; chemical registry /resource; chemical structure; combinatorial chemistry; mass spectrometry; photosynthesis; saltwater environment

DESCRIPTION (provided by applicant): Marine organisms have proven to be an important resource for new natural products. However, in many cases it is difficult, if not impossible, to ensure a constant supply of material for further biological testing and evaluation. Marine microalgae have been recognized as an important biological resource for new chemical compounds, but they remain underexploited, even today. Indeed, most studies of microalgae have been focused on those species that produce toxins, which represent a small percentage of the total group. However, the presence of toxins, often of unique structure, indicates that the producing organism has the biosynthetic capability to produce other unusual or exotic molecules. However these other non-toxic metabolites may be overlooked, and in addition may only be present in very small amounts. The UNCW Center for Marine Science (CMS) has a unique collection of over 300 clones of microalgae, representing several groups, of which only two species have been investigated by CMS scientists for the compounds they produce. This collection, coupled with the extensive culture scale-up and chemical processing facilities at CMS, ensures an unlimited supply of new chemical compounds. These compounds, as they are obtained, are characterized by the well-equipped structural organic chemistry group located at CMS. The libraries of compounds will be provided to NIH under the conditions of any award. Compounds will be accompanied by certificates of analysis, including structure elucidation. Compounds will be cataloged at CMS to permit re-isolation from cultured sources on a continual or increased basis, as needed.

描述（由申请人提供）：海洋生物已被证明是新天然产品的重要资源。然而，在许多情况下，即使不是不可能，也很难确保持续供应用于进一步生物测试和评估的材料。海洋微藻已被认为是新化合物的重要生物资源，但即使在今天，它们仍未得到充分开发。事实上，大多数对微藻的研究都集中在那些产生毒素的物种上，这些物种只占总藻类的一小部分。然而，毒素的存在（通常具有独特的结构）表明产生的生物体具有产生其他不寻常或外来分子的生物合成能力。然而，这些其他无毒代谢物可能会被忽视，而且可能仅以非常少量的形式存在。 UNCW 海洋科学中心 (CMS) 拥有超过 300 个微藻克隆的独特收藏，代表多个类群，其中只有两个物种被 CMS 科学家研究过它们产生的化合物。该系列产品与 CMS 广泛的培养规模扩大和化学加工设施相结合，确保了新化合物的无限供应。这些化合物，当它们获得时，其特征在于位于 CMS 的结构良好的有机化学基团。化合物库将根据任何奖励的条件提供给 NIH。化合物将附有分析证书，包括结构阐明。化合物将在 CMS 中编目，以便根据需要连续或增加地从培养源中重新分离。