2009 Biology of Aging Gordon Research Conference

2009年衰老生物学戈登研究会议

• 批准号: 7613586
• 负责人: DAVID A. SINCLAIR
• 金额: $ 5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7613586
• 关键词: Age; Aging; Aging-Related Process; Biology; Biology of Aging; California; Clinical; Collaborations; Diabetes Mellitus; Dietary Intervention; Disease; Faculty; Funding; Genetic; Gerontology; Goals; Health; Heart; Homeostasis; Human; Impaired cognition; Individual; Inflammation; Inflammatory; Intervention; Knowledge; Life; Longevity; Malignant Neoplasms; Molecular and Cellular Biology; Musculoskeletal System; Nerve Degeneration; Numbers; Organism; Pathology; Physiology; Postdoctoral Fellow; Quality of life; Range; Research; Research Personnel; Role; Running; Science; Scientist; Societies; Students; System; Time; Translating; Translational Research; age related; body system; cytokine; frailty; healthy aging; immunosenescence; improved; lifestyle intervention; novel therapeutics; programs; symposium; therapy development

DESCRIPTION (provided by applicant): Gordon Research Conference have taken place since 1931 and have been a critical venue for the dissemination of new and unpublished ideas in leading fields. The 2009 Gordon Research Conference on The Biology of Aging, titled "Mechanisms of Aging: Key Effectors and Rational Targets" will bring together investigators from the aging field with leaders in understanding the biology of major age-related diseases such as diabetes and cancer. The aging field has reached a point in time where it can seriously discuss the potential of translating scientific progress into clinical or lifestyle interventions that improve lives. In recent years, inflammation has emerged as a key driver of age- related diseases, and will form a continuing thread throughout the conference. We fully anticipate that the discussions and the collaborations set up at the meeting will help set the directions for the field of aging and accelerate the development of interventions to improve quality of life for millions of individuals. Funds are requested to provide partial support for the Gordon Research Conference (GRC) in the Biology of Aging. The theme of the 2009 conference will be "Mechanisms of Aging: Key Effectors and Rational Targets" to be held at the Four Points Sheraton Hotel, Ventura Beach, California from February 15-19, 2009. Drs Janet M Lord and David Sinclair will organize the scientific program. Our aim is to provide funds to support invited speakers, discussion leaders, and junior scientists (postdoctoral fellows, advanced graduate students, or new, junior faculty), who would benefit from and contribute to the conference. The speakers we have invited are internationally recognized for their research on the molecular and cellular biology of aging, the physiology and genetics of aging. We have also placed particular emphasis upon speakers who can contribute to a discussion on inflammation as a pleiotropic effector in the aging process and upon those researchers utilizing current understanding of aging to develop interventions to extend longevity and healthspan. Each of the speakers is a strong communicator of their science who can stimulate lively discussions. The current challenge to biogerontology is to determine how the various age-related changes, at the genetic and functional level, interact to result in loss of homeostasis, frailty and pathology. In particular, this conference will consider the age-related increase in pro-inflammatory cytokines, so-called "Inflammaging", as a candidate pleiotropic effector in the aging process in major organ systems. The conference will thus include sessions on neurodegeneration and cognitive decline, aging of the heart and musculoskeletal systems, the role of aging in cancer, and immunosenescence, with inflammation as a topic running through each session. In addition, it has become clear that several aspects of the aging process are malleable. In recent years, a large number of genetic, pharmacological and dietary interventions have been described that slow down aging in systems ranging from unicellular organisms to humans. This GRC will thus include discussion of interventions for healthy aging. The goals of the conference are: (i) To critically assess progress in the biology of aging; (ii) To utilize knowledge about the biology of aging to understanding age-related decline and major disease of society; and (iii) to emphasize integrative and translational research findings as a means to develop and validate novel therapeutics that could extend human health span.

描述（由申请人提供）：戈登研究会议自1931年以来举行了，一直是传播领先领域的新思想和未出版思想的关键场所。 2009年戈登衰老生物学研究会议的标题为“衰老机制：关键效应子和理性目标”，将与领导者一起将研究人员与领导者结合在一起，以理解与糖尿病和癌症等主要年龄相关疾病的生物学。衰老领域已经达到了一个时间点，它可以认真讨论将科学进步转化为改善生活的临床或生活方式干预措施的潜力。近年来，炎症已成为与年龄相关疾病的关键驱动力，并将在整个会议上形成持续的线索。我们完全预计会议上的讨论和合作将有助于为衰老领域设定指示，并加快干预措施的发展，以改善数百万个人的生活质量。要求资金在衰老生物学中为戈登研究会议（GRC）提供部分支持。 2009年会议的主题将是“衰老机制：关键效应子和理性目标”，将于2009年2月15日至19日在加利福尼亚州文图拉海滩的Sheraton Hotel举行。我们的目的是提供资金，以支持受邀演讲者，讨论领袖和初级科学家（博士后研究员，高级研究生或新的初级教师），他们将从会议上受益并为会议贡献。我们邀请的说话者因其对衰老的分子和细胞生物学，衰老的生理和遗传学的研究而受到国际认可。我们还特别强调说话者，他们可以在衰老过程中对炎症作为多效效应的讨论以及利用当前对衰老的理解来开发干预措施来扩展寿命和健康范围的那些研究人员。每个演讲者都是他们科学的强大沟通者，可以刺激活泼的讨论。当前对生物生态学的挑战是确定在遗传和功能水平上与各种年龄相关的变化如何相互作用，从而导致稳态，脆弱和病理的丧失。特别是，本次会议将考虑与年龄相关的促炎细胞因子（所谓的“炎症”）的年龄增加，这是主要器官系统衰老过程中的候选多效性效应子。因此，会议将包括有关神经变性和认知能力下降的会议，心脏和肌肉骨骼系统的衰老，衰老在癌症中的作用以及免疫衰老的作用，以及炎症是每个会议的主题。此外，很明显，衰老过程的几个方面是可延展的。近年来，已经描述了大量的遗传，药理和饮食干预措施，这些干预措施减慢了从单细胞生物到人类的系统的衰老。因此，该GRC将包括讨论健康衰老的干预措施。会议的目标是：（i）批判性地评估衰老生物学的进步； （ii）利用有关衰老生物学的知识来了解与年龄有关的衰落和社会的主要疾病； （iii）强调综合和转化研究发现是开发和验证可以扩展人类健康范围的新型治疗剂的一种手段。