THE GUT MICROBIOME IN DEVELOPMENT, HEALTH, AND DISEASE

描述（由申请人提供）：人体内的微生物至少是人体细胞的十倍。最近的数据 迫使我们认真考虑共同进化的微生物-宿主伙伴关系。是的， 事实上，是超级有机体和许多物种的复合体。这一新兴领域 这项研究对人类的发展、健康、体内平衡 和疾病，人类肠道生物量代表了最大的一部分， 这些有机体。基于这些原因，我们将提供一门关于人类的课程， 肠道微生物组在发育、健康和疾病中的作用， 北美儿科胃肠病学、肝病学和营养学会。 该课程将向儿科研究人员的广泛社区开放， 内科学、免疫学、微生物学、牙科学、皮肤学和其他 领域，并从这一学科的先驱小组专题讲座。话题 包括肠道微生物群在肠道和肠外的作用 炎症、免疫调节和益生菌生物学。那里 将特别强调学员，并准备在这个多方面的职业生涯 领域与肠道微生物组研究相关的生物学概念 将被强调。预计关于这一主题的首次课程将 促使广泛的调查人员获得与以下方面有关的技术培训： 该领域因为微生物组研究正在改变人类的基本概念， 生物学如此迅速，而且因为这个领域的受训者很少， 至关重要的是，调查人员要了解这些新出现的数据，以便他们能够 帮助将这些信息迅速有效地转化为有用知识， 是这门课的目标。

DESCRIPTION (provided by applicant): People contain at least ten-fold more microbial than human cells. Recent data compel serious consideration of co-evolved microbial-host partnerships. We are, in fact, super-organisms and composites of many species. This nascent field of study has tremendous implications for human development, health, homeostasis, and disease, and the human enteric biomass represents the largest fraction of these organisms. For these reasons, we will present a course on the human intestinal microbiome in development, health and disease, in conjunction with the North American Society for Pediatric Gastroenterology Hepatology and Nutrition. The course will be open to a wide community of investigators in pediatrics, internal medicine, immunology, microbiology, dentistry, dermatology, and other fields, and feature lectures from a panel of pioneers in this discipline. Topics to be covered include the role of the intestinal microbiota in intestinal and extraintestinal inflammation, immune regulation, and the biology of probiotics. There will be particular emphasis on trainees, and preparation for careers in this multifacetted field. Biologic concepts related to the study of the intestinal microbiome will be emphasized. It is anticipated that this inaugural course on this topic will prompt a wide range of investigators to obtain training in techniques relevant to this field. Because microbiome studies are changing basic concepts of human biology so rapidly, and because so few trainees in this field are in the pipeline, it is critical that investigators learn about these emerging data, so that they can help convert this information into useful knowledge rapidly and efficiently, which is the goal of the course.