Mutagenesis 2008 Gordon Research Conference

诱变 2008 年戈登研究会议

• 批准号: 7481663
• 负责人: Nancy Maizels
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-18 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7481663
• 关键词: Aging; Area; Biological; Collaborations; Critical Pathways; DNA Repair; Development; Fostering; Future; Genetic Recombination; Genetic Transcription; Genomic Instability; Genomics; Goals; Hereditary Disease; Human Genome; Immune response; Investigation; Knowledge; Maintenance; Malignant Neoplasms; Mismatch Repair; Molecular; Mutagenesis; Mutation; Nerve Degeneration; Neurodegenerative Disorders; Oxidative Stress; Pathway interactions; Physiological; Premature aging syndrome; Research; Research Personnel; Therapeutic; design; human disease; programs; symposium

DESCRIPTION (provided by applicant): Mutations initiate and facilitate the progression of a multitude of human diseases, especially cancer and neurodegenerative diseases; and mutagenic repair of DNA damage contributes to aging. The 2008 Gordon Research Conference on Mutagenesis will focus on the molecular mechanisms of mutagenesis that give rise to genomic instability. The goals of this meeting are (1) to explore current knowledge of mutagenesis mechanisms; (2) to identify new avenues of investigation; (3) to define therapeutic strategies for maintenance of genomic integrity; (4) to stimulate collaborations; and (5) to foster the long-term development of this critical research area. The program will specifically focus on advances that provide mechanistic understanding of pathways that maintain the integrity of the human genome, with emphasis on how these pathways intersect genetic disease, cancer, neurodegeneration and aging. The eight sessions will consider: (i) Mutagenesis Due to Blocked Replication and Transcription, (ii) Consequences of Oxidative Stress, (iii) Recombination Induced Genomic Instability, (iv) Physiological Mutagenesis in the Immune Response, (v) Rare Human Diseases Associated with Genomic Instability, Neurodegeneration and Premature Aging, (vi) Low-fidelity Replication and Cancer, (vii) Mechanisms of Mutagenesis, and (viii) Mismatch Repair: the Final Fidelity Check. The molecular and mechanistic emphasis on pathways critical in a variety of biological contexts is designed to attract a unique audience of researchers and propel their future research.

描述（由申请人提供）：突变引发并促进多种人类疾病的进展，特别是癌症和神经退行性疾病; DNA损伤的诱变修复有助于衰老。2008年戈登诱变研究会议将集中在引起基因组不稳定性的诱变的分子机制。本次会议的目标是（1）探索诱变机制的现有知识;（2）确定新的研究途径;（3）确定维持基因组完整性的治疗策略;（4）促进合作;（5）促进这一关键研究领域的长期发展。该计划将特别关注提供对维持人类基因组完整性的途径的机械理解的进展，重点是这些途径如何与遗传疾病，癌症，神经退行性疾病和衰老交叉。这八届会议将审议：（i）由于阻断复制和转录引起的突变，（ii）氧化应激的后果，（iii）诱变诱导的基因组不稳定性，（iv）免疫应答中的生理突变，（v）与基因组不稳定性、神经变性和过早衰老相关的罕见人类疾病，（vi）低保真度复制和癌症，（vii）突变机制，和（viii）不匹配修复：最终保真度检查。在各种生物学背景下对关键途径的分子和机制强调旨在吸引研究人员的独特受众并推动他们未来的研究。