5th Symposium on Polyamines in Parasites

描述（由申请人提供）： 第五届寄生虫多胺双年度研讨会将于2008年7月7日至9日在密歇根州底特律市的韦恩州立大学举行。帕特里克博士M.韦恩州立大学药学教授Woster当选为2008年会议组织者。Woster博士是过去三次寄生虫研讨会中多胺的特邀演讲者，并在过去两次研讨会中担任讨论负责人。2007年会议的重点将是多胺途径作为寄生原生动物和蠕虫的药物靶点。与会者将包括主要研究人员、博士后研究员、直接在会议领域工作的美国和国际实验室的学生以及当地的研究生和本科生。会议将是跨学科的性质;到目前为止，具有分子生物学，生物化学，遗传学，合成化学和结构生物学专业知识的与会者表示有兴趣参加会议。会议将由与会者提供的一系列30分钟的演讲组成，并将包括学生和博士后研究员展示他们工作的海报会议。会议的目标是评估寄生虫中多胺领域的研究状况，特别关注该途径作为细胞外和细胞内原生动物以及寄生蠕虫中药物靶点的效用。讨论的主题将包括：原生动物中的多胺代谢途径，寄生蠕虫中的多胺代谢途径，多胺酶药物靶标的验证，多胺酶的生化和结构表征，药物发现和抑制剂设计，以及耐药性机制。 致病寄生生物体含有多胺代谢酶，其在结构上不同于其人类对应物，或不存在于人类中，因此这些酶代表抗寄生虫药物发现的有吸引力的靶标。来自学术界和工业界的寄生虫多胺代谢、寄生虫酶结构和抗寄生虫药物发现领域的科学专家将于2008年7月7日至9日在韦恩州立大学举行的第五届寄生虫多胺两年一度的研讨会上会面。会议的目标是评估寄生虫中多胺领域的研究状况，发展新的科学合作，协调药物发现工作，以确定治疗不受控制的寄生虫病的有效药物。

DESCRIPTION (provided by applicant): The 5th Biennial Symposium on Polyamines in Parasites will be held at Wayne State University in Detroit, Michigan on July 7-9, 2008. Dr. Patrick M. Woster, Professor of Pharmaceutical Sciences at Wayne State University was elected to serve as the 2008 conference organizer. Dr. Woster has been an invited speaker at the past three Polyamines in Parasites symposia, and served as a discussion leader at the past two symposia. The focus of the 2007 meeting will be the polyamine pathway as a drug target in parasitic protozoa and helminths. Participants will include principal investigators, postdoctoral fellows, and students from both United States and international laboratories that are working directly in the area of the meeting, as well as local students at the graduate and undergraduate level. The meeting will be interdisciplinary in nature; thus far, participants with expertise in molecular biology, biochemistry, genetics, synthetic chemistry, and structural biology have expressed interest in attending the meeting. The meeting will be composed of a series of 30 min talks given by meeting participants and will include a poster session for students and postdoctoral fellows to present their work. The goal of the meeting is to assess the state of research in the area of polyamines in parasites, focusing particularly upon the utility of this pathway as a drug target in both extracellular and intracellular protozoa, as well as in parasitic worms. Topics for discussion will include: Polyamine Metabolic Pathways in Protozoa, Polyamine Metabolic Pathways in Parasitic Worms, Validation of Polyamine Enzyme Drug Targets, Biochemical and Structural Characterization of Polyamine Enzymes, Drug Discovery and Inhibitor Design, and Drug Resistance Mechanisms. Disease-causing parasitic organisms contain polyamine metabolic enzymes that are structurally distinct from their human counterparts, or that do not exist in humans, and thus these enzymes represent attractive targets for antiparasitic drug discovery. Scientific experts in the areas of parasite polyamine metabolism, parasitic enzyme structure and antiparasitic drug discovery from both academia and industry will meet at the 5th Biennial Symposium on Polyamines in Parasites, to be held at Wayne State University on July 7-9, 2008. The goal of the meeting is to assess the state of research in the area of polyamines in parasites, develop new scientific collaborations and coordinate drug discovery efforts, with the aim of identifying effective drug treatments for uncontrolled parasitic diseases.