2009 Polyamines GRC & GRS

描述(申请人提供)：自1975年以来，多胺GRC一直是一个多学科的会议，重点关注多胺代谢途径，多胺在细胞内稳态中的作用，以及作为潜在治疗剂调节多胺代谢的小分子的发展。这次会议被广泛认为是介绍和讨论多胺研究的最好场所。多胺-戈登大会将于2009年6月21日至26日在新罕布夏州沃特维尔山谷的沃特维尔山谷度假村举行。多胺是一种小的有机聚阳离子，几乎存在于所有原核和真核细胞中。尽管它们的重要性和普遍存在，多胺的细胞功能还没有完全了解。多胺与细胞生长密切相关，因此多胺生物合成的抑制剂被作为抗增殖剂加以推广。多胺在转录、翻译和蛋白质周转水平上受到高度调控。因此，该领域聚集了对多胺在各种生物体(哺乳动物细胞、酵母、原生动物和细菌)中的生理作用感兴趣的研究人员和对癌症、寄生虫或细菌感染等治疗应用感兴趣的研究人员。越来越清楚的是，多胺在不同的生物体中具有独特的作用，而且不同物种之间的生物合成和分解代谢途径以及相关的调节机制也有很大差异。2009年多胺-戈登研究会议将由在抗癌药物开发和抗寄生虫剂开发领域中处于多胺研究前沿的科学家发表演讲。此外，会议将包括介绍多胺代谢在细胞内稳态中的作用，重点是遗传、表观遗传和生理控制的基本机制。会议将包括30分钟的演讲，然后是10分钟的讨论时间，以及两个海报会议。它还将包括学生或博士后的简短演讲，他们的作品是从组委会的海报演示中挑选出来的。为了进一步鼓励学生和博士后科学家参加会议，多胺GRC将与第二届戈登-凯南多胺研究生研究研讨会(GKGRS)同时举行。GKGRS将于6月20日至21日举行，参加GKGRS的学生和博士后也将参加紧随其后的GRC例会。 公共卫生相关性：多胺是一种小的有机聚阳离子，存在于几乎所有原核和真核细胞中，是正常细胞功能所必需的。了解多胺的正常代谢是理解细胞功能的关键，异常的多胺代谢和功能被认为是发现癌症和其他疾病新的治疗药物的靶点。多胺戈登研究会议是该领域最杰出的科学会议，为国际知名研究人员提供了一个论坛，讨论他们的研究成果并保持积极的科学合作。

DESCRIPTION (provided by applicant): Since 1975, the Polyamine GRC has been a multidisciplinary conference focused on the polyamine metabolic pathway, the role of polyamines in cellular homeostasis and the development of small molecules that modulate polyamine metabolism as potential therapeutic agents. This meeting is widely regarded as the pre-eminent venue for the presentation and discussion of polyamine research. The Polyamine Gordon conference will be held at the Waterville Valley Resort in Waterville Valley, New Hampshire from June 21-26, 2009. Polyamines are small organic polycations found in virtually all prokaryotic and eukaryotic cells. Despite their importance and ubiquitous occurrence, the cellular functions of polyamines are not fully understood. Polyamines are closely linked to cell growth, and as such inhibitors of polyamine biosynthesis are promoted as anti-proliferative agents. Polyamines are highly regulated at the levels of transcription, translation and protein turnover. Thus the field brings together researchers interested in the physiological role of polyamines in a wide array of organisms (mammalian cells, yeast, protozoa and bacteria) and researchers interested in therapeutic applications such as cancer and parasitic or bacterial infection. It is becoming increasingly clear that polyamines have unique roles in different organisms, and further that the biosynthetic and catabolic pathways, as well as the associated regulatory mechanisms, vary widely among different species. The 2009 Polyamine Gordon Research Conference will feature presentations from scientists in the forefront of polyamine research in the areas of anticancer drug development and the development of antiparasitic agents. In addition, the meeting will include presentations outlining the role of polyamine metabolism in cellular homeostasis, with an emphasis on basic mechanisms of genetic, epigenetic and physiological control. The meeting will be composed of 30 minute talks followed by a 10 minute discussion period, and two poster sessions. It will also include short talks by students or postdocs whose work has been chosen from the poster presentations by the organizing committee. In order to further encourage the participation of student and postdoctoral scientists in the meeting, the Polyamine GRC will be held in conjunction with the second Gordon-Kenan Graduate Research Seminar (GKGRS) on Polyamines. The GKGRS will be held from June 20-21, and students and postdocs participating in the GKGRS will be expected to also attend the regular GRC meeting, which immediately follows. Public Health Relevance: Polyamines are small organic polycations that are found in virtually all prokaryotic and eukaryotic cells, and that are absolutely required for normal cellular function. An understanding of normal polyamine metabolism is critical to the understanding of cellular function, and aberrant polyamine metabolism and function are regarded as targets for the discovery of new therapeutic agents for cancer and other diseases. The Polyamines Gordon Research Conference, the pre-eminent scientific meeting in the field, provides a forum for internationally known researchers to discuss their research results and maintain active scientific collaborations.