2009 Polyamines GRC & GRS

2009 聚胺GRC

• 批准号: 7672110
• 负责人: Patrick M Woster
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7672110
• 关键词: Anabolism; Antineoplastic Agents; Antiparasitic Agents; Area; Bacteria; Bacterial Infections; Cell physiology; Collaborations; Development; Disease; Epigenetic Process; Eukaryotic Cell; Genetic; Genetic Transcription; Homeostasis; Link; Malignant Neoplasms; Mammalian Cell; Metabolic Pathway; Metabolism; New Hampshire; Organism; Pathway interactions; Physiological; Polyamines; Protozoa; Research; Research Personnel; Resort; Role; Scientist; Students; Therapeutic; Therapeutic Agents; Translations; Work; Yeasts; cell growth; drug development; inhibitor/antagonist; interest; meetings; multidisciplinary; novel therapeutics; polycation; posters; protein degradation; public health relevance; small molecule; symposium

DESCRIPTION (provided by applicant): Since 1975, the Polyamine GRC has been a multidisciplinary conference focused on the polyamine metabolic pathway, the role of polyamines in cellular homeostasis and the development of small molecules that modulate polyamine metabolism as potential therapeutic agents. This meeting is widely regarded as the pre-eminent venue for the presentation and discussion of polyamine research. The Polyamine Gordon conference will be held at the Waterville Valley Resort in Waterville Valley, New Hampshire from June 21-26, 2009. Polyamines are small organic polycations found in virtually all prokaryotic and eukaryotic cells. Despite their importance and ubiquitous occurrence, the cellular functions of polyamines are not fully understood. Polyamines are closely linked to cell growth, and as such inhibitors of polyamine biosynthesis are promoted as anti-proliferative agents. Polyamines are highly regulated at the levels of transcription, translation and protein turnover. Thus the field brings together researchers interested in the physiological role of polyamines in a wide array of organisms (mammalian cells, yeast, protozoa and bacteria) and researchers interested in therapeutic applications such as cancer and parasitic or bacterial infection. It is becoming increasingly clear that polyamines have unique roles in different organisms, and further that the biosynthetic and catabolic pathways, as well as the associated regulatory mechanisms, vary widely among different species. The 2009 Polyamine Gordon Research Conference will feature presentations from scientists in the forefront of polyamine research in the areas of anticancer drug development and the development of antiparasitic agents. In addition, the meeting will include presentations outlining the role of polyamine metabolism in cellular homeostasis, with an emphasis on basic mechanisms of genetic, epigenetic and physiological control. The meeting will be composed of 30 minute talks followed by a 10 minute discussion period, and two poster sessions. It will also include short talks by students or postdocs whose work has been chosen from the poster presentations by the organizing committee. In order to further encourage the participation of student and postdoctoral scientists in the meeting, the Polyamine GRC will be held in conjunction with the second Gordon-Kenan Graduate Research Seminar (GKGRS) on Polyamines. The GKGRS will be held from June 20-21, and students and postdocs participating in the GKGRS will be expected to also attend the regular GRC meeting, which immediately follows. Public Health Relevance: Polyamines are small organic polycations that are found in virtually all prokaryotic and eukaryotic cells, and that are absolutely required for normal cellular function. An understanding of normal polyamine metabolism is critical to the understanding of cellular function, and aberrant polyamine metabolism and function are regarded as targets for the discovery of new therapeutic agents for cancer and other diseases. The Polyamines Gordon Research Conference, the pre-eminent scientific meeting in the field, provides a forum for internationally known researchers to discuss their research results and maintain active scientific collaborations.

描述（由申请人提供）：自1975年以来，多胺GRC一直是一个多学科会议，专注于多胺代谢途径、多胺在细胞稳态中的作用以及作为潜在治疗剂的调节多胺代谢的小分子的开发。这次会议被广泛认为是介绍和讨论多胺研究的杰出场所。多胺戈登会议将于2009年6月21日至26日在新罕布什尔州沃特维尔山谷的沃特维尔山谷度假村举行。多胺是几乎所有原核和真核细胞中发现的小的有机聚阳离子。尽管它们的重要性和普遍存在，多胺的细胞功能尚未完全了解。多胺与细胞生长密切相关，因此多胺生物合成的抑制剂作为抗增殖剂被推广。多胺在转录、翻译和蛋白质周转水平上受到高度调节。因此，该领域汇集了对多胺在各种生物体（哺乳动物细胞，酵母，原生动物和细菌）中的生理作用感兴趣的研究人员，以及对癌症和寄生虫或细菌感染等治疗应用感兴趣的研究人员。越来越清楚的是，多胺在不同的生物体中具有独特的作用，并且进一步地，生物合成和分解代谢途径以及相关的调节机制在不同的物种中差异很大。2009年多胺戈登研究会议将有来自抗癌药物开发和抗寄生虫药物开发领域多胺研究前沿的科学家的演讲。此外，会议将包括介绍概述多胺代谢在细胞内稳态中的作用，重点是遗传，表观遗传和生理控制的基本机制。会议将包括30分钟的会谈，随后是10分钟的讨论时间和两个海报会议。它还将包括学生或博士后的简短演讲，他们的作品是从组委会的海报展示中选出的。为了进一步鼓励学生和博士后科学家参加会议，多胺GRC将与第二届戈登-凯南多胺研究生研究研讨会（GKGRS）一起举行。GKGRS将于6月20日至21日举行，参加GKGRS的学生和博士后也将参加随后举行的定期GRC会议。 公共卫生相关性：多胺是一种小的有机聚阳离子，几乎存在于所有的原核和真核细胞中，并且是正常细胞功能所必需的。了解正常的多胺代谢对于了解细胞功能至关重要，并且异常的多胺代谢和功能被认为是发现癌症和其他疾病的新治疗剂的靶点。多胺戈登研究会议是该领域的杰出科学会议，为国际知名的研究人员提供了一个论坛，讨论他们的研究成果并保持积极的科学合作。