2008 Proteoglycans Gordon Research Conference

2008年蛋白多糖戈登研究会议

• 批准号: 7533667
• 负责人: Thomas N Wight
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-03 至 2009-01-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7533667
• 关键词: Area; Arthritis; Autoimmunity; Biology; Bone Diseases; Cardiovascular Diseases; Collaborations; Connective Tissue; Depth; Disabled Persons; Disease; Drug Formulations; Ensure; Europe; Funding; Glycosaminoglycans; Goals; Human Development; Immunity; Inflammation; International; Japan; Knowledge; Lead; Malignant Neoplasms; Muscular Dystrophies; Musculoskeletal System; Nerve Degeneration; Nervous system structure; Numbers; Outcome; Personal Satisfaction; Pharmaceutical Preparations; Plant Roots; Proteoglycan; Public Health; Research; Research Personnel; Role; Scandinavia; Scientist; Structure; Technology; Today; Tumor Cell Invasion; Underrepresented Minority; Ursidae Family; Vascular System; Week; Woman; Work; abstracting; concept; human disease; insight; novel; posters; programs; proteoglycan core protein; symposium

DESCRIPTION (provided by applicant): / Abstract The Gordon Conference on Proteoglycans, held every two years since 1984, brings together an international group of investigators for a week of dynamic interactions and in-depth discussion of recent advances in the field. Speakers will be invited to present recent, novel, and exciting findings in nine plenary sessions, supplemented by short talks, and poster presentations. The Proteoglycan field is truly international, with hubs of excellence in Scandinavia, Europe, Japan, and the USA, among others. Conference attendance has historically reflected this international excellence, with approximately 45% from outside the USA. Thus, NIH-funded investigators can meet face-to-face with other top researchers, to share their recent findings, and to set up collaborations to advance our understanding of proteoglycans and disease mechanisms. Proteoglycan biology is rooted in the area of connective tissue and arthritis. This pioneering work provided early insight into the structure and interactions of proteoglycan core protein and glycosaminoglycan chains that proved critical for normal connective tissue function. This led to an intense search for and description of other proteoglycans. Today, the "players" in the field have largely been identified, and research is focused on discovering new mechanisms and functions, and extending these findings to an increasing number of diseases, including neurodegeneration, inflammation and autoimmunity, tumor invasion, cardiovascular disease, muscular dystrophy, bone diseases, and others. As the field expands, we find ourselves joined by experts in these areas who wish to expand their work to include proteoglycans. Thus, a central aim of the Gordon Conference on Proteoglycans is to invite these scientists to share their research and knowledge, thus broadening the field by bringing the widest and best expertise possible to bear on understanding the role of proteoglycans in human disease. Finally, the Proteoglycan field is well-known for its collegiality, open discussions, and support of junior investigators. A concerted effort has been and will be made by the Chair and Program Committee to ensure representation of under- represented minorities, including women and persons with disabilities, and thus bolster opportunities to contribute to the field. of Research to Public Health The goal of the conference is to promote the exchange of ideas, new findings, concepts, and technology related to proteoglycan research into human disease. It is anticipated that the outcome of the conference will be an enhanced understanding of numerous human diseases, including those of human development, the musculoskeletal system, nervous system, vascular system, immunity, and cancer, and that this understanding will ultimately lead to the formulation of new drugs and treatments for combating these diseases.

描述（由申请人提供）：/ 摘要 自 1984 年以来，戈登蛋白聚糖会议每两年举行一次，国际研究人员小组聚集在一起，进行为期一周的动态互动，并深入讨论该领域的最新进展。演讲者将被邀请在九场全体会议上介绍最新的、新颖的、令人兴奋的发现，并辅以简短的演讲和海报展示。蛋白多糖领域是真正的国际化领域，在斯堪的纳维亚半岛、欧洲、日本和美国等地设有卓越中心。从历史上看，会议出席人数反映了这种国际卓越水平，大约 45% 来自美国以外的地区。因此，美国国立卫生研究院资助的研究人员可以与其他顶尖研究人员面对面交流，分享他们的最新发现，并建立合作，以增进我们对蛋白多糖和疾病机制的理解。蛋白多糖生物学植根于结缔组织和关节炎领域。这项开创性的工作提供了对蛋白聚糖核心蛋白和糖胺聚糖链的结构和相互作用的早期见解，这被证明对正常结缔组织功能至关重要。这导致了对其他蛋白多糖的深入研究和描述。如今，该领域的“参与者”已基本确定，研究重点是发现新的机制和功能，并将这些发现扩展到越来越多的疾病，包括神经退行性疾病、炎症和自身免疫、肿瘤侵袭、心血管疾病、肌营养不良、骨疾病等。随着该领域的扩展，我们发现这些领域的专家也加入了我们的行列，他们希望将他们的工作扩展到包括蛋白聚糖。因此，戈登蛋白多糖会议的一个中心目标是邀请这些科学家分享他们的研究和知识，从而通过提供最广泛和最好的专业知识来了解蛋白多糖在人类疾病中的作用，从而拓宽领域。最后，蛋白多糖领域以其同事关系、公开讨论和初级研究人员的支持而闻名。主席和计划委员会已经并将继续共同努力，确保代表性不足的少数群体（包括妇女和残疾人）的代表性，从而增加为该领域做出贡献的机会。公共卫生研究会议的目标是促进与人类疾病蛋白多糖研究相关的思想、新发现、概念和技术的交流。预计会议的成果将是加深对许多人类疾病的了解，包括人类发育、肌肉骨骼系统、神经系统、血管系统、免疫和癌症的疾病，这种了解最终将导致制定对抗这些疾病的新药和治疗方法。