Understanding the development of autoimmunity in response to citrullinated peptide antigen presentation to T cells in rheumatoid arthritis

了解类风湿性关节炎中瓜氨酸肽抗原呈递给 T 细胞时自身免疫的发展

• 批准号: nhmrc : 1083192
• 负责人: Dr Hugh Reid
• 金额: $ 78.8万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-development-autoimmunity-rheumatoid-arthritis/518921
• 关键词: Understanding; development; autoimmunity; response; citrullinated

Rheumatoid arthritis (RA) is a systemic autoimmune disease predominantly affecting synovial joints, in 1% of adults worldwide. HLA-class II genes underlie the major genetic susceptibility to RA. The programme of work brings together 7 investigators from 3 countries to determine how autoimmunity develops to self antigens in individuals at genetic risk of RA and why resistance alleles are protective against RA, in Caucasian, Asian and North American Native populations. We will provide a molecular

类风湿关节炎（RA）是一种主要影响滑膜关节的系统性自身免疫性疾病，全世界有1%的成年人患病。hla II类基因是类风湿性关节炎的主要遗传易感性。工作规划汇集了来自3个国家的7名研究人员，以确定在高加索、亚洲和北美土著人群中，具有类风湿关节炎遗传风险的个体中，自身免疫如何发展为自身抗原，以及为什么抗性等位基因对类风湿关节炎具有保护作用。我们将提供一个分子