FASEB Summer Research Conference "Trace Element Metabolism: Basic and Applied Res

描述（由申请人提供）： 本申请是对FASEB夏季研究会议“微量元素代谢：从模式生物到人类”的部分支持，该会议将于2008年6月15-20日在科罗拉多斯诺马斯举行。鉴于微量元素在全球人类营养和人类疾病中的重要性以及这一研究领域的重要进展，我们预计在2010年和2012年至少再举行两次这一会议。微量元素在医学、农业以及农业与人类健康之间的相互关系中至关重要。本次拟议的FASEB夏季研究会议将重点关注的主题涵盖了最令人兴奋和最重要的突破，了解微量元素稳态和代谢的基础和应用方面。在本次会议中，我们将主要关注微量元素铁（Fe），铜（Cu），锌（Zn），硒（Se）和硼（B），因为它们构成了一组在生物学中起关键作用的微量元素。正如新发现的生物过程的数量急剧增加所证明的那样，在这些过程中，微量元素作为催化剂、传感器、调节分子和结构辅助因子发挥着关键作用，这一研究领域正在以极快的速度扩展。鉴于该领域的重要性及其继续做出具有广泛根本重要性的突破性发现的潜力，以及对交流和互动机会的大量科学需求，本次会议的主题既令人兴奋又及时。该提案的具体目的是（1）组织和支持关于微量元素体内平衡和代谢研究领域最新科学进展的会议（2）促进科学家与临床医生/科学家和学员之间的互动，分享微量元素代谢领域的新发现，因为它与正常生长有关，发展和营养，并加强培训和新的合作，将推动该领域的发展和（3）直接参与新的独立科学家和学员，包括研究生和博士后研究员，妇女，少数民族和残疾人参加会议。我们的目标是通过口头和海报介绍提供接触尖端科学的机会，让学员与既定的研究人员和其他同事之间有机会互动，并鼓励和支持生物医学研究这一重要领域的长期和重大进展。微量元素如铜和铁是人体正常生长和发育所必需的，但当积累到高水平时是有毒的。本申请是对一个研究会议的部分支持，该会议作为一个论坛，以促进我们对生物体如何适当平衡微量元素使用的理解，并利用这些知识来促进由遗传、环境和饮食机制引起的人类微量元素代谢疾病的诊断和治疗。

DESCRIPTION (provided by applicant): This application is for partial support of a FASEB Summer Research Conference on "Trace Element Metabolism: From Model Organisms to Humans", to be held at Snowmass, Colorado June 15-20, 2008. Given the importance of trace elements in global human nutrition and in human disease and the important advances in this field of research, we anticipate holding at least two additional iterations of this meeting in 2010 and 2012. Trace elements are of vital importance in medicine, agriculture and the inter-relationship between agriculture and human health. This proposed FASEB Summer Research Conference will focus on topics covering the most exciting and important breakthroughs in understanding both basic and applied aspects of trace element homeostasis and metabolism. In this meeting we will largely focus on the trace elements iron (Fe), copper (Cu), zinc (Zn), selenium (Se) and boron (B), as they constitute a group of trace elements that serve critical roles in biology. As is evidenced by the dramatic increase in the number of newly discovered biological processes in which trace elements play pivotal roles as catalysts, sensors, regulatory molecules and structural co-factors, this field of investigation is expanding at an extremely rapid pace. Given the importance of the field and its potential to continue to make ground-breaking discoveries of broad fundamental importance and the large scientific demand for opportunities to communicate and interact, the topic of this meeting is both exciting and timely. The specific aims for this proposal are to (1) organize and support a meeting on the latest scientific advances in the research area of trace element homeostasis and metabolism (2) promote interactions between scientists and clinician/scientists and trainees to share new discoveries in the field of trace element metabolism as it relates to normal growth, development and nutrition and to enhance training and new collaborations that will move the field forward and (3) to directly involve newly independent scientists and trainees including graduate students and postdoctoral fellows, women, minorities and the disabled in the conference. Our goal is to provide access to cutting edge science via oral and poster presentations, to allow opportunities for interactions between trainees and established investigators and other colleagues and to encourage and support long- term and significant advances in this important area of biomedical research. Proposal Narrative Description Trace elements such as copper and iron are essential for normal human growth and development, but are toxic when accumulated to high levels. This application is for partial support of a research conference to serve as a forum to advance our understanding of how organisms properly balance trace element usage and to utilize this knowledge to facilitate the diagnosis and treatment of human diseases of trace element metabolism caused by genetic, environmental and dietary mechanisms.