2015 Cell Biology of Metals Gordon Research Conference

 描述(由申请人提供)： 戈登研究会议(GRC)的“金属细胞生物学：从微生物到人类的机制”为生物中新兴金属领域的科学交流、演讲和讨论提供了一个杰出的论坛，重点关注从细菌到人类的蛋白质、细胞和系统中金属的获取、分布、传感和利用。该GRC系列于2005年启动，在下一个周期立即获得超额认购，这表明该会议填补了探索蛋白质、细胞器和整个生物体中金属利用的分子机制的一个重要利基。这次会议现在已经成为该领域的基石，在解决广泛的研究问题方面是独一无二的，例如辅因子是如何组装的，金属离子如何在代谢和传染病中发挥作用。金属细胞生物学GRC每两年举行一次，一直吸引了约150人参加。戈登研究会议系列以其会议的高质量、尖端性质而享誉国际，展示了未发表的作品，本次会议的计划努力保持这一高标准。2015年金属细胞生物学GRC将于7月26日至31日在佛蒙特州西多佛市的雪山度假村举行。这个应用程序描述了该程序，该程序围绕“从微生物到人类的机制”这一主题进行组织。会议主题包括金属、反应性和环境；金属蛋白的结构生物学；金属动态平衡和疾病；辅因子组装、金属定位和信号；宿主-病原体轴上的金属；以及生物学中金属的工具和技术。会议将由主题演讲、研究和海报演讲、海报讨论和非正式科学讨论组成。这次会议将汇聚一批杰出和多样化的分子和结构生物学家、生物化学家、遗传学家、细胞生物学家、生理学家和临床医生，就金属细胞生物学基础和应用研究的新发现、新想法和新方向进行交流和集思广益。鉴于与细胞金属稳态变化相关的代谢性和感染性疾病的数量增加，本次会议填补了研究这些疾病的潜在机制(S)以及集思广益的新诊断、预后和治疗方法的关键利基。

 DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on the "Cell Biology of Metals: Mechanisms from Microbes to Humans" provides an outstanding forum for scientific exchanges, presentations and discussions in the emerging field of metals in biology, focusing on the acquisition, distribution, sensing and utilization of metals in proteins, cells and systems from bacteria to humans. This GRC series was initiated in 2005 and in the next cycle was immediately oversubscribed, illustrating that the meeting filled an important niche exploring the molecular mechanisms of metal utilization in proteins, organelles, and whole organisms. This conference has now become a cornerstone of the field and is unique in attacking broad research questions such as how cofactors are assembled to how metal ions play roles in metabolic and infectious diseases. The Cell Biology of Metals GRC is held every two years and has consistently attracted around 150 attendees. The Gordon Research Conference series is internationally renowned for the high-quality, cutting edge nature of its meetings, showcasing unpublished work, the program of this conference strives to maintain this high standard. The 2015 Cell Biology of Metals GRC will be held on July 26 - 31 at Mount Snow Resort in West Dover, VT. This application describes the program, which is organized around the theme of "Mechanisms from Microbes to Humans". Session topics include metals, reactivity, and the environment; structural biology of metalloproteins; metal homeostasis and disease; cofactor assembly, metal localization and signaling; metals at the host-pathogen axis; and tools and technologies for metals in biology. The conference will be comprised of keynote presentations, research and poster talks, poster discussions, and informal scientific discussions. This meeting will bring together an outstanding and diverse cadre of molecular and structural biologists, biochemists, geneticists, cell biologists physiologists and clinicians to interact and brainstorm on new discoveries, ideas and directions in basic and applied research on the cell biology of metals. Given the increase in the number of metabolic and infectious diseases linked to changes in cellular metal homeostasis, this meeting fills a critical niche for investigating the underlying mechanism(s) of these disorders and for brainstorming approaches for novel diagnostics, prognostics, and therapeutics.