Micronutrient Malnutrition and EBV Persistence in Children

儿童微量营养素营养不良和 EBV 持续存在

基本信息

批准号：
7431286
负责人：
ROSEMARY ROCHFORD
金额：
$ 3.9万
依托单位：
UPSTATE MEDICAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7431286
关键词：
Address Africa African Burkitt&apos s lymphoma Age Age of Onset Antimalarials Antioxidants Antiviral Agents Applications Grants Area B-Lymphocytes Beds Biology Blood Blood specimen Burkitt Lymphoma CD8B1 gene Cancer Etiology Cells Charge Child Child Malnutrition Childhood Collaborations Cross-Sectional Studies Data Data Analyses Databases Developed Countries Developing Countries Diet Habits Disease Enrollment Environmental Exposure Enzyme-Linked Immunosorbent Assay Enzymes Epstein-Barr Virus Infections Etiology Euphorbia Exposure to Figs - dietary Frequencies Funding Goals Grant Health Height Homeostasis Human Herpesvirus 4 Immunity Incidence Individual Infection Infectious Agent International Internet Investigation Joints Kenya Knowledge Laboratories Life Maintenance Malaria Malignant Childhood Neoplasm Malignant Neoplasms Malnutrition Measurement Measures Medical Micronutrients Mothers Outcome Parasitemia Peripheral Pharmaceutical Preparations Phenotype Plants Polymerase Chain Reaction Populations at Risk Positioning Attribute Premalignant Prophylactic treatment Province Public Health Publications Questionnaires Recording of previous events Research Research Institute Research Personnel Research Project Grants Research Proposals Risk Role Scientist Score Selenium Soil Students Supervision Supplementation T-Lymphocyte Technology Testing Time Trace Elements Training Travel United States National Institutes of Health Universities Viral Viral Load result Virulence Virus Shedding Visit Weight Work Writing base cancer risk cancer type cofactor cohort demographics early childhood experience field study glutathione peroxidase health disparity infancy micronutrient deficiency nutrition parent grant prevent programs response sample collection selenium deficiency transmission process vector

项目摘要

DESCRIPTION (provided by applicant): Endemic Burkitt's lymphoma (BL) is the most common childhood cancer in low-lying humid regions of Equatorial Africa. In Kenya, the cancer is endemic in Nyanza Province. Within Nyanza Province, we have identified high risk and low risk clusters of BL. Two known co-factors for BL have been identified: holoendemic malaria and EBV infection. Holoendemic malaria transmission occurs throughout Nyanza Province and infection with EBV is not geographically restricted. This suggests that other co-factors in addition to EBV and holoendemic malaria increase the risk for BL resulting in the high-risk clusters of BL. Several lines of evidence suggest that another potential cofactor is micronutrient deficiency such as selenium. Selenium deficiency is associated with several types of cancer and selenium supplementation is chemopreventative for reducing cancer risks. We hypothesize that selenium deficiency occurs in the high BL risk area compared to the low BL risk area and thus could be an additional co-factor increasing the risk for BL. Furthermore, we hypothesize that selenium deficiency results in increased EBV viral load. In this proposal we will test these hypotheses by completing the following aims: determine selenium levels in children living in regions with low and high risk for BL and determine if reduced selenium levels correlate with elevated EBV viral load in children. We will perform a cross-sectional analysis of children living within two high-BL risk regions and two low-BL risk regions we identified in Nyanza Province. This proposal builds on our ongoing research projects in Kenya and the long- standing collaboration between the two co-investigators, one at SUNY Upstate and one at the Kenya Medical Research Institute (KEMRI). As an outcome of the proposed investigations, we expect to determine how selenium deficiencies correlate with 2 known co-factors, EBV and malaria, in a cohort of children at risk for developing BL. This knowledge is critical to determining the etiology of BL and ultimately, to prevent BL. This research will be done primarily in Kisumu, Kenya at the Center for Vector Biology Research and Control, Kenya Medical Research Institute in collaboration with P. Odada Sumba, as an extension of NIH grant #R01CA102667. Public Health Relevance: Burkitt's lymphoma remains the most common childhood malignancy in Equatorial Africa. We are studying what causes this cancer and why it is so common in children. We are testing the hypothesis that essential micronutrients are deficient in children that are living in a region in Kenya where there is a high risk for getting Burkitt's lymphoma.

描述（由申请人提供）：流行伯基特的淋巴瘤（BL）是赤道非洲低洼潮湿地区最常见的儿童癌症。在肯尼亚，癌症在Nyanza省是地方性的。在Nyanza省内，我们确定了BL的高风险和低风险簇。已经确定了两个已知的BL副因素：全肺疟疾和EBV感染。全能疟疾的传播发生在整个Nyanza省，EBV感染并不受地理限制。这表明，除EBV和HoloEmentamic疟疾外，其他共同因素会增加BL的风险，从而导致BL的高风险簇。几条证据表明，另一个潜在的辅助因子是微量营养素缺乏症，例如硒。硒缺乏症与几种类型的癌症有关，补充硒是降低癌症风险的化学预防性。我们假设与低BL风险区域相比，硒缺乏症发生在高BL风险区域，因此可能是增加BL风险的额外的副因素。此外，我们假设硒缺乏会导致EBV病毒负荷增加。在此提案中，我们将通过完成以下目的来检验这些假设：确定居住在BL风险低和高风险的儿童中的硒水平，并确定硒水平降低是否与儿童EBV病毒负荷升高相关。我们将对生活在Nyanza省发现的两个高BL风险区域和两个低BL风险区域的儿童进行横断面分析。这项提议建立在我们在肯尼亚正在进行的研究项目的基础上，以及两个共同研究者之间的长期合作，一项在纽约州立大学上州，一个在肯尼亚医学研究所（Kemri）。作为拟议调查的结果，我们希望确定硒缺陷如何与2个已知的共同因素EBV和疟疾相关联，这是一系列面临发展BL风险的儿童。这些知识对于确定BL的病因和最终预防BL至关重要。这项研究将主要在肯尼亚媒介生物学研究与控制中心的Kisumu，肯尼亚医学研究所与P. Odada Sumba合作，作为NIH Grant＃R01CA102667的扩展。公共卫生相关性：伯基特的淋巴瘤仍然是赤道非洲最常见的儿童恶性肿瘤。我们正在研究导致这种癌症的原因以及为什么在儿童中如此普遍。我们正在检验以下假设：在肯尼亚的一个地区，基本的微量营养素缺乏患有伯基特淋巴瘤的风险很高的儿童。