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Micronutrient Malnutrition and EBV Persistence in Children

儿童微量营养素营养不良和 EBV 持续存在

基本信息

批准号：
7587370
负责人：
ROSEMARY ROCHFORD
金额：
$ 3.9万
依托单位：
UPSTATE MEDICAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7587370
关键词：
Address Africa African Burkitt&apos s lymphoma Age Age of Onset Antimalarials Antioxidants Antiviral Agents Applications Grants Area B-Lymphocytes Beds Biology Blood Blood specimen Burkitt Lymphoma CD8B1 gene Cancer Etiology Cells Charge Child Child Malnutrition Childhood Collaborations Cross-Sectional Studies Data Data Analyses Databases Developed Countries Developing Countries Diet Habits Disease Enrollment Environmental Exposure Enzyme-Linked Immunosorbent Assay Enzymes Epstein-Barr Virus Infections Etiology Euphorbia Exposure to Figs - dietary Frequencies Funding Goals Grant Health Height Homeostasis Human Herpesvirus 4 Immunity Incidence Individual Infection Infectious Agent International Internet Investigation Joints Kenya Knowledge Laboratories Life Maintenance Malaria Malignant Childhood Neoplasm Malignant Neoplasms Malnutrition Measurement Measures Medical Research Micronutrients Mothers National Institute of Environmental Health Sciences Outcome Parasitemia Peripheral Pharmaceutical Preparations Phenotype Plants Plasmodium falciparum Populations at Risk Positioning Attribute Premalignant Prophylactic treatment Province Publications Questionnaires Recording of previous events Research Research Institute Research Personnel Research Project Grants Research Proposals Risk Role Scientist Selenium Soil Students Supervision Supplementation T-Lymphocyte Technology Testing Time Trace Elements Training Travel United States National Institutes of Health Universities Viral Viral Load result Virulence Virus Shedding Visit Weight Work Writing base cancer risk cancer type cofactor cohort demographics early childhood experience field study glutathione peroxidase graduate student health disparity high risk infancy micronutrient deficiency nutrition parent grant prevent programs public health relevance response sample collection selenium deficiency transmission process vector

项目摘要

DESCRIPTION (provided by applicant): Endemic Burkitt's lymphoma (BL) is the most common childhood cancer in low-lying humid regions of Equatorial Africa. In Kenya, the cancer is endemic in Nyanza Province. Within Nyanza Province, we have identified high risk and low risk clusters of BL. Two known co-factors for BL have been identified: holoendemic malaria and EBV infection. Holoendemic malaria transmission occurs throughout Nyanza Province and infection with EBV is not geographically restricted. This suggests that other co-factors in addition to EBV and holoendemic malaria increase the risk for BL resulting in the high-risk clusters of BL. Several lines of evidence suggest that another potential cofactor is micronutrient deficiency such as selenium. Selenium deficiency is associated with several types of cancer and selenium supplementation is chemopreventative for reducing cancer risks. We hypothesize that selenium deficiency occurs in the high BL risk area compared to the low BL risk area and thus could be an additional co-factor increasing the risk for BL. Furthermore, we hypothesize that selenium deficiency results in increased EBV viral load. In this proposal we will test these hypotheses by completing the following aims: determine selenium levels in children living in regions with low and high risk for BL and determine if reduced selenium levels correlate with elevated EBV viral load in children. We will perform a cross-sectional analysis of children living within two high-BL risk regions and two low-BL risk regions we identified in Nyanza Province. This proposal builds on our ongoing research projects in Kenya and the long- standing collaboration between the two co-investigators, one at SUNY Upstate and one at the Kenya Medical Research Institute (KEMRI). As an outcome of the proposed investigations, we expect to determine how selenium deficiencies correlate with 2 known co-factors, EBV and malaria, in a cohort of children at risk for developing BL. This knowledge is critical to determining the etiology of BL and ultimately, to prevent BL. This research will be done primarily in Kisumu, Kenya at the Center for Vector Biology Research and Control, Kenya Medical Research Institute in collaboration with P. Odada Sumba, as an extension of NIH grant #R01CA102667. Public Health Relevance: Burkitt's lymphoma remains the most common childhood malignancy in Equatorial Africa. We are studying what causes this cancer and why it is so common in children. We are testing the hypothesis that essential micronutrients are deficient in children that are living in a region in Kenya where there is a high risk for getting Burkitt's lymphoma.

描述（由申请人提供）：地方性伯基特淋巴瘤（BL）是赤道非洲低洼潮湿地区最常见的儿童癌症。在肯尼亚，这种癌症在尼扬扎省流行。在尼扬扎省，我们已经确定了高风险和低风险的BL集群。已经确定了BL的两个已知的辅助因素：全地方性疟疾和EBV感染。全地方性疟疾传播发生在整个尼扬扎省，EB病毒感染不受地理限制。这表明，除了EBV和全地方性疟疾之外的其他辅助因素增加了BL的风险，导致BL的高风险集群。一些证据表明，另一个潜在的辅因子是微量营养素缺乏症，如硒。硒缺乏与几种类型的癌症有关，硒补充剂是降低癌症风险的化学预防剂。我们推测，与低BL风险地区相比，高BL风险地区发生硒缺乏，因此可能是增加BL风险的额外辅助因素。此外，我们假设硒缺乏导致EBV病毒载量增加。在本提案中，我们将通过完成以下目标来测试这些假设：确定生活在BL低风险和高风险地区的儿童的硒水平，并确定硒水平降低是否与儿童EBV病毒载量升高相关。我们将对生活在我们在尼扬扎省确定的两个高BL风险地区和两个低BL风险地区的儿童进行横断面分析。这项建议建立在我们正在肯尼亚进行的研究项目和两个共同研究者之间的长期合作基础上，一个在纽约州立大学北部，一个在肯尼亚医学研究所（KEMRI）。作为拟议的调查结果，我们希望确定硒缺乏如何与2个已知的辅助因素，EB病毒和疟疾，在一个队列的儿童在发展BL的风险。这些知识对于确定BL的病因并最终预防BL至关重要。这项研究将主要在肯尼亚基苏穆的肯尼亚医学研究所病媒生物学研究和控制中心与P. Odada Sumba合作进行，作为NIH资助#R01CA 102667的延伸。公共卫生相关性：伯基特淋巴瘤仍然是赤道非洲最常见的儿童恶性肿瘤。我们正在研究这种癌症的原因以及为什么它在儿童中如此常见。我们正在检验一个假设，即生活在肯尼亚一个地区的儿童缺乏必要的微量营养素，那里有患伯基特淋巴瘤的高风险。