The Third RGS Protein Colloquium

描述（由申请人提供）：真核生物中最常用的信号转导机制涉及激活异源三聚体G蛋白的七种跨膜受体。G蛋白介导大量信号分子的作用，包括神经递质、激素、细胞因子、大多数药物和成瘾药物以及视觉和嗅觉。1996年，G蛋白信号调节蛋白（Regulators of G Protein Signaling，RGS）被发现是G蛋白信号机制的基本组成部分。人类体内存在数十种RGS蛋白。它们由G蛋白GT3激活结构域定义，其作用是终止信号传导，但通常具有多个其他结构域，其功能是积极研究的主题。本申请寻求对将于2008年4月4-5日在加利福尼亚州圣地亚哥举行的第三届RGS蛋白质学术讨论会的支持。学术讨论会将是2008年实验生物学会议的卫星。它与这一大型会议的联系确保了学术讨论会的高水平宣传，并将通过方便出席来增加参与。财政支助将用于资助发言者出席会议的旅费，并通过降低费用鼓励青年科学家参加会议。RGS蛋白质研讨会已经成为唯一一次专门讨论RGS蛋白质的会议，并提供了一个重要的论坛，让这一领域的研究人员相互交流，其中大多数是年轻人和/或这个快速发展的领域的新手。一批杰出的发言者已经承诺参加这次学术讨论会，其中包括研究生和一般事务领域的知名领导人以及新的调查人员。将从会议登记者中选出一组额外的发言者，为年轻或新进入该领域的调查人员提供更多的机会。两次海报会议将为更多的年轻科学家提供展示其工作的机会，并将促进所有与会者之间的互动。会议将讨论以下主题：1）RGS结构/功能; 2）RGS靶向/细胞定位; 3）新型相互作用/功能; 4）RGS体内作用。将通过会议网站向公众提供会议材料，以扩大学术讨论会的影响。

DESCRIPTION (provided by applicant): The most commonly used signal transduction mechanism in eukaryotes involves seven transmembrane receptors that activate heterotrimeric G proteins. G proteins mediate the effects of a vast array of signaling molecules including neurotransmitters, hormones, cytokines, the majority of pharmaceutical and addictive drugs, as well as the senses of vision and olfaction. In 1996, Regulators of G Protein Signaling (RGS) proteins were discovered as a fundamental component of the G protein signaling mechanism. Dozens of RGS proteins exist in humans. They are defined by a G protein GTPase activation domain that acts to terminate signaling, but often have multiple other domains whose functions are the subject of active investigation. This application seeks support for the Third RGS Protein Colloquium, to be held April 4-5, 2008 in San Diego, CA. The Colloquium will be satellite of the Experimental Biology 2008 conference. Its association with this massive conference ensures a high level of publicity for the Colloquium and will increase participation by making attendance convenient. Financial support will be used to fund travel to the meeting by speakers, and to encourage the participation of young scientists by reducing their costs. The RGS Protein Colloquia have emerged as the sole meeting devoted to RGS proteins, and provide an essential forum to allow investigators in this field to interact with each other, most of them young and/or new to this fast-growing field. A group of outstanding speakers have already committed to the Colloquium, including established leaders in the RGS field as well as new investigators. A set of additional speakers will be chosen from among meeting registrants to provide more opportunities for investigators who are young or new to the field. Two poster sessions will provide opportunities for yet more young scientists to present their work and also will facilitate interaction among all attendees. Sessions at the meeting will be devoted to the following topics: 1) RGS structure/function; 2) RGS targeting/cellular localization; 3) Novel interactions/functions; 4) RGS action in vivo. Meeting materials will be made available to the public via the conference web site to increase the impact of the Colloquium.