ASM Conference on Manipulation of Nuclear Processes by DNA Viruses

描述(由申请人提供)： 传染病是全世界主要的死亡原因，约占所有死亡人数的25%--每年总计1700万人。虽然这些死亡大多发生在发展中国家，但发达国家也很容易受到影响。自然病原体以及生物恐怖主义、传染病病原体对公共卫生和国家安全构成重大威胁。此外，人们越来越意识到，传染病病原体可能在癌症和心脏病等慢性疾病的病因学中发挥作用。病毒感染和致病机制对人类和动物种群都有巨大的影响，长期以来，病毒与宿主的相互作用被认为在决定病毒感染过程中发挥着重要作用。这次会议将聚集研究在细胞核中复制的DNA病毒的研究人员：多瘤病毒、乳头状瘤病毒、腺病毒和疱疹病毒，讨论在细胞核中发生的病毒宿主相互作用。越来越清楚的是，这些DNA病毒与许多相同的宿主途径相互作用。除了非常大的ASV型会议形式外，几乎没有机会开会讨论核DNA病毒如何操纵东道主以推动其议程的异同。不幸的是，在80年代初，疱疹病毒学家停止了与研究较小DNA病毒的研究人员的会面。在这项提议中，我们打算将核DNA病毒学家聚集在一起，讨论这些重要的病毒如何操纵细胞核。目前该领域的研究旨在了解DNA病毒如何以各种方式操纵细胞核，包括与DNA修复、蛋白酶体、伴侣和应激反应途径的相互作用。病毒与宿主转录机制和核仁的相互作用以及在细胞核中运行的固有抗病毒防御机制将被考虑。与癌基因和肿瘤抑制因子的相互作用也将被讨论。尽管多瘤、乳头状瘤、腺病毒和疱疹病毒与一些相同的宿主细胞途径相互作用，但每个病毒家族都进化出独特的策略，以创造有利于病毒基因表达和复制的核环境。DNA病毒包括许多引起疾病的人类病原体，从轻微的肠道和呼吸道感染到毁灭性的急性感染、慢性进行性神经疾病和癌症。感染这些病原体的结果通常取决于宿主抗病毒防御反应的相互作用，以及病毒为颠覆和逃离这些系统而采取的对策。我们组织了一次题为“DNA病毒操纵核过程”的会议，这次会议将汇集研究核病毒与宿主相互作用的不同科学家。所有的DNA病毒都会改变特定的细胞系统来加强它们的繁殖和传播，这一领域的几个令人兴奋的发展使人们能够及时地研究不同病毒使用的共同和独特的机制。

DESCRIPTION (provided by applicant): Infectious diseases are the leading cause of mortality worldwide, accounting for approximately 25% of all deaths - a total of 17 million per year. Although most of these deaths occur in developing countries, developed countries are also vulnerable. Naturally occurring agents as well as bioterrorism infectious disease agents pose significant threats to public health and national security. In addition, there is a growing awareness that infectious agents may play a role in the etiology of chronic diseases such as cancer and heart disease. Viral infection and pathogenesis have a huge impact on both human and animal populations Virus- host interactions have long been recognized as playing important roles in determining the course of viral infection. This meeting will bring together researchers who work on DNA viruses which replicate in the nucleus: Polyoma-, Papilloma-, Adeno- and Herpesviruses to discuss virus host interactions occurring in the nucleus. It is becoming clear that these DNA viruses interact with many of the same host pathways. Except for the very large ASV type meeting format, there are few opportunities to meet to discuss the similarities and differences in how nuclear DNA viruses manipulate the host to promote their agenda. Unfortunately, in the early 80s the herpesvirologists stopped meeting with researchers working on smaller DNA viruses. In this proposal, we intend to bring together nuclear DNA virologists to discuss how these important viruses manipulate the nucleus. Current research in the area is aimed at understanding how DNA viruses manipulate the nucleus in various ways including interactions with DNA repair, proteosomal, chaperone and stress response pathways. Viral interactions with the host transcriptional machinery and the nucleolus as well as innate antiviral defense mechanisms which operate in the nucleus will be considered. Interactions with oncogenes and tumor suppressors will also be discussed. Although Polyoma-, Papilloma-, Adeno- and Herpesviruses interact with some of the same host cell pathways, each virus family has evolved unique strategies to create a nuclear environment conducive to viral gene expression and replication. The DNA viruses include many human pathogens causing maladies varying from mild enteric and respiratory infections to devastating acute infections, chronic progressive neurological diseases, and cancer. The outcome of infection with these agents is often determined by the interplay of the hosts antiviral defense responses, and countermeasures that viruses mount to subvert and escape these systems. We have organized a meeting entitled "Manipulation of Nuclear Processes by DNA Viruses" that will bring together a diverse collection of scientists that study nuclear virus-host interactions. All of the DNA viruses alter specific cellular systems to enhance their propagation and spread, and several exciting developments in this field make a meeting that examines the common and unique mechanisms used by different viruses timely.