LONG TERM FOLLOW-UP OF RECIPIENTS OF GENE TRANSFER
基因转移接受者的长期随访
基本信息
- 批准号:7716637
- 负责人:
- 金额:$ 0.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-20 至 2008-11-30
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsAftercareBlood specimenCellsComputer Retrieval of Information on Scientific Projects DatabaseFundingFutureGene TransferGrantInstitutionLearningLengthMalignant NeoplasmsMethodsPurposeResearchResearch PersonnelResourcesRetroviridaeSafetySamplingSourceTestingUnited States National Institutes of HealthVirusexperiencefollow-upgene therapy
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Subjects who have participated in a prior gene transfer study will be asked to participate in this study. The purpose of this study is to complete follow-up and to learn about the long-term side effects of gene therapy. Participation in this study is expected to last for at least 15 years. The length of follow up may be extended in the future.
Because there is so little experience with using gene transfer for treatment, all subjects who participated in gene transfer studies are expected to participate in long-term follow up. This is done so that any late problems that could be related to gene therapy can be evaluated. As part of this follow-up, investigators want to collect a blood sample each year that could be tested later for replication-competent retrovirus (RCR, virus from the original gene therapy that may be able to divide later and infect new cells on its own). These samples would be tested if there were a reason to suspect RCR. Gene therapy has been used for only a few years, and, because there is so little experience with this form of treatment, there is incomplete information about long-term safety. In one study which used a retrovirus gene transfer method, cancers occurred at approximately 3 years after treatment. This was associated with the retrovirus used. It is not known whether gene therapy can cause other late side effects.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
将要求既往参加过基因转移研究的受试者参加本研究。 本研究的目的是完成随访,并了解基因治疗的长期副作用。 参与本研究的时间预计至少持续15年。随访时间可能会在未来延长。
由于使用基因转移进行治疗的经验很少,因此预计所有参与基因转移研究的受试者都将参与长期随访。这样做是为了评估任何可能与基因治疗有关的晚期问题。作为这项后续工作的一部分,研究人员希望每年收集一份血液样本,以便以后对复制能力逆转录病毒(RCR,来自原始基因治疗的病毒,可能能够在以后分裂并自行感染新细胞)进行检测。如果有理由怀疑RCR,则将对这些样本进行检测。基因治疗仅使用了几年,而且由于这种治疗形式的经验很少,因此有关长期安全性的信息不完整。在一项使用逆转录病毒基因转移方法的研究中,癌症发生在治疗后约3年。这与使用的逆转录病毒有关。目前尚不清楚基因治疗是否会引起其他晚期副作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John A Zaia其他文献
ISOLATED GROWTH HORMONE DEFICIENCY IN ASSOCIATION WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION
孤立性生长激素缺乏症与人类免疫缺陷病毒(HIV)感染相关
- DOI:
10.1203/00006450-198704010-00503 - 发表时间:
1987-04-01 - 期刊:
- 影响因子:3.100
- 作者:
John D Miller;John A Zaia - 通讯作者:
John A Zaia
John A Zaia的其他文献
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{{ truncateString('John A Zaia', 18)}}的其他基金
Stem Cell Gene Therapy Following R-EPOCH for Non-Hodgkin Lymphoma in AIDS Patient
R-EPOCH 后的干细胞基因治疗艾滋病患者非霍奇金淋巴瘤
- 批准号:
8639234 - 财政年份:2014
- 资助金额:
$ 0.48万 - 项目类别:
Stem Cell Gene Therapy Following R-EPOCH for Non-Hodgkin Lymphoma in AIDS Patient
R-EPOCH 后的干细胞基因治疗艾滋病患者非霍奇金淋巴瘤
- 批准号:
8805835 - 财政年份:2014
- 资助金额:
$ 0.48万 - 项目类别:
Evaluating New Targets of CMV Cellular Immunity
评估 CMV 细胞免疫的新靶点
- 批准号:
7987158 - 财政年份:2010
- 资助金额:
$ 0.48万 - 项目类别:
Evaluating New Targets of CMV Cellular Immunity
评估 CMV 细胞免疫的新靶点
- 批准号:
8464666 - 财政年份:2010
- 资助金额:
$ 0.48万 - 项目类别:
Evaluating New Targets of CMV Cellular Immunity
评估 CMV 细胞免疫的新靶点
- 批准号:
8110085 - 财政年份:2010
- 资助金额:
$ 0.48万 - 项目类别:
Evaluating New Targets of CMV Cellular Immunity
评估 CMV 细胞免疫的新靶点
- 批准号:
8265719 - 财政年份:2010
- 资助金额:
$ 0.48万 - 项目类别:
CLINICAL TRIAL: CMV-SPECIFIC CELLULAR IMMUNITY IN RECIPIENTS OF ALLOGENIC BONE M
临床试验:同种异体骨 M 接受者的 CMV 特异性细胞免疫
- 批准号:
7716632 - 财政年份:2008
- 资助金额:
$ 0.48万 - 项目类别:
LONG TERM FOLLOW-UP OF RECIPIENTS OF GENE TRANSFER
基因转移接受者的长期随访
- 批准号:
7982056 - 财政年份:2008
- 资助金额:
$ 0.48万 - 项目类别:
CLINICAL TRIAL: A PHASE I DOSE ESCALATION STUDY OF PEPTIDE VACCINES WITH ACTIVIT
临床试验:活性肽疫苗的 I 期剂量递增研究
- 批准号:
7982075 - 财政年份:2008
- 资助金额:
$ 0.48万 - 项目类别:
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