MEASUREMENT OF CARDIAC OUTPUT BY NON-INVASIVE DETECTION OF INDICATOR DILUTION

通过指标稀释的无创检测来测量心输出量

• 批准号: 7716697
• 负责人: JEAN-MICHEL MAREK
• 金额: $ 1.32万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716697
• 关键词: Animals; Beds; Body Surface; Calibration; Cardiac Output; Clinical; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Coupled; Critical Illness; Data; Detection; Dyes; Fluorescence; Funding; Grant; Indocyanine Green; Institution; Invasive; Measurement; Methods; Non-Invasive Cancer Detection; Optics; Patients; Placement; Procedures; Research; Research Personnel; Resources; Signal Transduction; Source; Techniques; Testing; Thermodilution; United States National Institutes of Health; base; healthy volunteer; intravenous injection; non-invasive monitor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This pilot clinical trial in healthy volunteers investigates a new minimally invasive method for clinical measurement of the cardiac output that circumvents limitations of currently available method for invasive and non-invasive monitoring of cardiac output. The new method is based on the transcutaneous detection of indocyanine green fluorescence following an intravenous injection of the dye. The studies aim at comparing different placements of the optical probe on the body surface with respect to ntensity and stability fluorescence signal, testing a calibration procedure for the method, and verifying that the new method tracks cardiac output changes induced by passive bed tilt. Successful completion of the proposed trial coupled with ongoing animal studies should produce sufficient preliminary data for an application to the NIH for testing of the technique in critically ill patients by comparison with the reference thermodilution method.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项在健康志愿者中进行的初步临床试验研究了一种新的微创心输出量临床测量方法，该方法规避了目前可用的心输出量有创和无创监测方法的局限性。新方法是基于静脉注射染料后经皮检测吲哚菁绿色荧光。研究的目的是比较不同的放置在身体表面上的光学探头的强度和稳定性的荧光信号，测试校准程序的方法，并验证新的方法跟踪心输出量的变化引起的被动床倾斜。成功完成拟议的试验加上正在进行的动物研究应产生足够的初步数据，用于向NIH申请通过与参考热稀释法进行比较，在危重患者中测试该技术。