North and Central Texas Clinical and Translational Science Initiative (KL2)

德克萨斯州北部和中部临床和转化科学计划 (KL2)

• 批准号: 7497173
• 负责人: Milton Packer
• 金额: $ 148.83万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-17 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497173
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We propose to establish a North and Central Texas Clinical and Translational Science Initiative (NCTCTSI), which will be led by the University of Texas Southwestern Medical School at Dallas and will include many of the nation's leading schools of allopathic and osteopathic medicine, dentistry, nursing, pharmacy, public health, engineering and computer science - which have already formed a highly functional relationship supported by a Roadmap K12 award. We have established a Department of Clinical Sciences, which is supported by faculty from all participating schools and which will serve as the academic home for our CTSA. The Department provides academic appointments to clinical and translational investigators together with faculty whose expertise and research is focused on methodological disciplines common to all clinical research - in order to promote multidisciplinary team building and problem solving. The NCTCTSI will build on existing nationally-recognized programs supported by K30, M01 and Roadmap K12 awards and will integrate numerous institutional strengths to offer 10 highly innovative and fully integrated key functions: (1) faculty recruitment, development and recognition; (2) research education, training and career development; (3) research plan development and support; (4) scientific review and investment; (5) regulatory knowledge and support; (6) participant and clinical interactions resources; (7) novel research methodology development; (8) translational technologies and resources; (9) biomedical informatics; and (10) community engagement. Particular strengths are: (1) the substantial and unequivocal commitment of participating institutions to the Initiative (which have pledged ~ $125 million to the NCTCTSI over the next five years); (2) an established academic and cultural home that currently address many of the goals of the NIH; (3) > 200 established clinical and translational investigators who will act as faculty and mentors; (4) a highly innovative approach to integrating key functions that will act to create bonds among the members of a multidisciplinary academic community; (5) a large and medically diverse patient base cared for by internationally-renowned hospitals (which are strong supporters of this initiative); (6) > $150 million in annual peer-reviewed grant support for clinical studies; (7) superb infrastructure to support clinical and translational research; and (8) program leadership with the time, experience and commitment to ensure the success of the Initiative. The coordinated synthesis of these strengths will allow the NCTCTSI to contribute to the national CTSA consortium and thus help to identify best practices that will benefit clinical and translational research throughout the nation.

我们建议在德克萨斯州北部和中部建立一个诊所 和翻译科学倡议(NCTCTSI)，该倡议将由德克萨斯大学领导 位于达拉斯的西南医学院，将包括许多全国领先的 对抗疗法和骨科医学、牙科、护理、药剂学、公共卫生、工程学和 计算机科学-它们已经形成了一种高度有用的关系，由一个 路线图K12奖。我们成立了临床科学系，由以下机构提供支持 来自所有参与学校的教职员工，将作为我们CTSA的学术之家。这个 为临床和翻译研究人员提供学术任命，并与 其专业知识和研究集中在所有临床共有的方法学学科上 研究--以促进多学科团队建设和问题解决。NCTCTSI将 以K30、M01和Roadmap K12奖项支持的现有国家认可计划为基础 并将整合众多机构优势，提供10个高度创新和全面整合的关键 职能：(1)教师招聘、发展和认可；(2)研究教育、培训和 职业发展；(3)研究计划的制定和支持；(4)科学审查和投资； (5)监管知识和支持；(6)参与者和临床互动资源；(7)新颖 研究方法发展；(8)翻译技术和资源；(9)生物医学信息学；和(10)社区参与。具体的优势是：(1)实质性和 参与机构对该倡议的明确承诺(它们已认捐约1.25亿美元 (2)现有的学术和文化中心，目前 满足NIH；(3)&GT；200成熟的临床和翻译研究人员的许多目标 将充当教员和导师；(4)以高度创新的方法整合将发挥作用的关键职能 在多学科学术社区的成员之间建立联系；(5)大型和 由国际知名医院(实力雄厚)照顾的医疗多样化的患者基础 这一倡议的支持者)；(6)&GT；1.5亿美元，用于临床研究的年度同行审查赠款支持； (7)支持临床和转化性研究的一流基础设施；以及(8)具有 确保倡议取得成功所需的时间、经验和承诺。配位综合 这些优势将使NCTCTSI能够为国家CTSA财团做出贡献，从而帮助 确定将在全国范围内有益于临床和转化研究的最佳实践。