North and Central Texas Clinical and Translational Science Initiative (KL2)

德克萨斯州北部和中部临床和转化科学计划 (KL2)

• 批准号: 7666962
• 负责人: Milton Packer
• 金额: $ 106.56万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-17 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7666962
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We propose to establish a North and Central Texas Clinical and Translational Science Initiative (NCTCTSI), which will be led by the University of Texas Southwestern Medical School at Dallas and will include many of the nation's leading schools of allopathic and osteopathic medicine, dentistry, nursing, pharmacy, public health, engineering and computer science - which have already formed a highly functional relationship supported by a Roadmap K12 award. We have established a Department of Clinical Sciences, which is supported by faculty from all participating schools and which will serve as the academic home for our CTSA. The Department provides academic appointments to clinical and translational investigators and to faculty whose expertise and research is focused on methodological disciplines common to all clinical research - in order to promote multidisciplinary team building and problem solving. The NCTCTSI will build on existing nationallyrecognized programs supported by K30, M01 and Roadmap K12 awards and will integrate numerous institutional strengths to offer 12 highly innovative and fully integrated key functions: (1) building a unique academic home for clinical and translational research; (2) transforming a culture: investigator development and recognition; (3) research education, training and career development; (4) biomedical informatics; (5) stimulating novel translational ideas and methodologies; (6) support for pilot and collaborative studies; (7) research study development: design, statistics and ethics; (8) scientific review and evaluation; (9) regulatory knowledge and support; (10) participant and clinical interactions resources; (11) community engagement; and (12) translational technologies and resources. Particular strengths are: (1) a substantial financial commitment of participating institutions to the Initiative; (2) an established academic and cultural home that currently addresses many of the goals of the NIH; (3) > 200 established clinical and translational investigators who will act as faculty and mentors; (4) a highly innovative approach to integrating key functions that will act to create bonds among the members of a multidisciplinary academic community; (5) a large and medically diverse patient base cared for by internationally-renowned hospitals (which are strong supporters of this initiative); (6) > $150 million in annual peer-reviewed grant support for clinical studies; (7) superb infrastructure to support clinical and translational research; and (8) program leadership with the time, experience and commitment to ensure the success of the Initiative. The coordinated synthesis of these strengths will allow the NCTCTSI to improve the health of our community and to contribute to the national CTSA consortium and thus help to identify best practices that will benefit clinical and translational research throughout the nation.

我们建议建立德克萨斯州北部和中部的临床和转化科学倡议 (NCTCTSI)，该项目将由德克萨斯大学达拉斯西南医学院和 将包括全国许多领先的对抗疗法和骨科医学、牙科、 护理、药学、公共卫生、工程和计算机科学--它们已经形成了一个 由路线图K12奖支持的高度功能性关系。我们已经建立了一个 临床科学系，由所有参与学校的教职员工和 它将作为我们CTSA的学术之家。本系提供学术研究 任命临床和翻译研究人员以及其专业知识和研究 专注于所有临床研究共同的方法学学科--以促进 多学科团队建设和问题解决。NCTCTSI将建立在现有的国家公认的基础上 由K30、M01和Roadmap K12奖项支持的计划，并将集成许多 提供12项高度创新和全面整合的关键职能的机构优势：(1)建设 临床和转化性研究的独特学术之家；(2)转变文化：调查员 发展和认可；(3)研究教育、培训和职业发展；(4) 生物医学信息学；(5)激发新的翻译思想和方法；(6)支持 试验性和协作性研究；(7)研究性研究发展：设计、统计和伦理；(8) 科学审查和评估；(9)监管知识和支持；(10)参与者和临床 互动资源；(11)社区参与；以及(12)翻译技术和 资源。特别的优点是：(1)参与的大量财政承诺 倡议的机构；(2)现有的学术和文化之家 NIH；(3)&GT；200的许多目标是建立临床和翻译研究人员，他们将采取行动 作为教师和导师；(4)高度创新的方法来整合关键职能，将发挥作用 在多学科学术社区的成员之间建立联系；(5)大型和 由国际知名医院(实力雄厚)照顾的医疗多样化的患者基础 这一倡议的支持者)；(6)&GT；每年1.5亿美元的同行审查赠款支持临床 研究；(7)支持临床和转化性研究的一流基础设施；和(8)计划 我们将以时间、经验和承诺发挥领导作用，确保该倡议取得成功。这个 这些优势的协调综合将使NCTCTSI能够改善我们的健康 并向国家CTSA财团作出贡献，从而帮助确定最佳做法 这将使全国各地的临床和翻译研究受益。