CERAMIC HOLLOW FIBRE SOLVENT NANOFILTRATION MEMBRANES

有机溶剂纳滤(OSN)是一种用于有机溶液中分子水平分离的新型分离工艺，在化学和制药研究和生产中有许多可能的应用。目前很少有稳定的溶剂膜，也没有为极性非质子溶剂(如THF、DMF和DMSO)或这些溶剂与水的混合物提供稳定和实际通量的膜。这项研究寻求突破--通过单步制造形成中空纤维形式的陶瓷纳滤膜，其外径通常小于2 mm。为了实现这一点，我们将开发和建立由申请人最近开发的新的浸没诱导混合矩阵相位反转(IIPIMM)方法。该项目涉及开发膜并评价其在制药行业常见的溶剂回收中的用途。可以预期，与有机膜相比，新开发的膜具有良好的耐热性、较高的化学稳定性和溶剂稳定性、较长的运行周期。该项目的成果将帮助英国学术界和工业界走在陶瓷中空纤维发明所带来的一些关键发展的前沿。

Organic Solvent Nanofiltration (OSN) is a new separation process for molecular level separations in organic solutions, with many possible applications across chemical and pharmaceutical research and manufacturing. There are currently very few solvent stable membranes, and none available which offer stability and practical fluxes for polar aprotic solvents such as THF, DMF and DMSO, or mixtures of these solvents with water. This research seeks a breakthrough- the formation of ceramic nanofiltration membranes in a hollow fibre form, of typically less than 2 mm outer diameter, through single step fabrication. To achieve this, we will exploit and build upon the novel immersion induced phase inversion of mixed matrices (IIPIMM) method recently developed by the applicants. The project involves the development of the membrane and evaluation of its use for solvent recovery commonly found in pharmaceutical industries. It can be expected that the newly developed membrane should have good thermal resistance, high chemical and solvent stability, long running period in comparison with the organic membranes. The results of the project will aid the UK academic and industrial communities to be at the forefront of some of the key developments made possible by the invention of ceramic hollow fibres.