Core--Animal and Infection

核心--动物与感染

• 批准号: 7439103
• 负责人: JOHN CHAN
• 金额: $ 20.41万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7439103
• 关键词: Animal Experimentation; Animals; Ants; Bacillus (bacterium); Breeding; Collaborations; Containment; Containment of Biohazards; Core Facility; Data; Disease; Epidemic; Fostering; Genes; Genotype; Goals; HIV; Host Defense; Human; Immune response; Individual; Infection; Intervention; Laboratories; Maintenance; Modeling; Mouse Strains; Multi-Drug Resistance; Mus; Mycobacterium tuberculosis; Pathogenesis; Productivity; Public Health; Research Design; Research Infrastructure; Research Personnel; Safety; Testing; Time; Transgenic Organisms; Tuberculosis; Vaccine Design; Vaccines; Virulent; animal facility; cost effectiveness; design; in vivo; knockout gene; pathogen; programs; research study; vaccine efficacy; vaccine evaluation

Tuberculosis remains a major public health burden. With the emergence of multi-drug resistant strains of Mycobacterium tuberculosis and the sustained HIV epidemic worldwide, the threat of tuberculous infection can be expected to continue for quite some time. Clearly, effective ant-ituberculosis intervention is urgently needed. The goal of this Program Project is to design safe and efficacious anti-tuberculous vaccines. For such an endeavor, animal experimentation designed to evaluate vaccine safeness and efficacy is indispensable. The goal of Core B is to provide the investigators participating in this Program Project with the infrastructure to carry out animal studies. Specifically, Core B will i) maintain a safe, efficient, and up-to-date biosafey-level 3 containment animal facility; ii) provide assistance in the design of animal experiemnts, in data interpretation, and in the technical aspects of the various aerogenic models of murine experimental tuberculosis; iii) maintenance and breeding of specific transgenic and gene-disrupted mice. We believe a central core facility for animal studies will fulfill important goals of a Program Project: i) to enhance efficiency, cost-effectiveness, and productivity of the individual participating laboratories, and ii)to foster interaction and collaboration among the investigators.

结核病仍然是主要的公共卫生负担。随着多药耐药的出现 结核分枝杆菌的菌株和全球持续的HIV流行，威胁 结核感染可以持续很长时间。显然，迫切需要有效的静态结核干预。该计划项目的目的是设计安全有效的抗通结疫苗。对于这样的努力，旨在评估疫苗安全性和功效的动物实验是必不可少的。核心B的目的是为参加该计划项目的研究人员提供基础设施，以进行动物研究。具体而言，核心B将i）维持安全，高效且最新的生物保护层3遏制动物设施； ii）在动物体验，数据解释以及鼠实验性结核病的各种充气模型的技术方面提供帮助； iii）特定的转基因和基因脱离小鼠的维持和繁殖。我们认为，动物研究的核心核心设施将实现计划项目的重要目标：i）提高个人参与实验室的效率，成本效益和生产力，以及ii）促进研究人员之间的互动和协作。