Factors Associated with Insulin Reluctance in Individuals with Type 2 Diabetes

2 型糖尿病患者胰岛素抵抗的相关因素

• 批准号: 7488144
• 负责人: Soohyun Nam
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-14 至 2010-05-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7488144
• 关键词: Accounting; Acute; Address; Adult; Affect; American; Applications Grants; Attitude; Behavior; Belief; Caring; Centers for Disease Control and Prevention (U.S.); Chronic Disease; Class; Clinical; Cross-Sectional Studies; Diabetes Mellitus; Disease; Dose; Education; Educational Intervention; Educational workshop; Ethnic group; Exposure to; Health; Health Personnel; Health Professional; Individual; Insulin; Knowledge; Linear Regressions; Medical; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Participant; Patient Care; Patients; Perception; Personal Satisfaction; Population; Prevalence; Psychosocial Factor; Public Health; Purpose; Questionnaires; Research; Research Design; Research Personnel; Risk; Self Efficacy; Self Management; Testing; Time; Training; United States; Work; care systems; design; diabetic; glycemic control; pre-doctoral; predictive modeling; prevent; psychologic; satisfaction; statistics

DESCRIPTION (provided by applicant): The purpose of this training grant application (F31) is to provide predoctoral support that will allow this investigator to examine the factors associated with a reluctance to use insulin therapy in individuals with type 2 diabetes. Common misconceptions about the need for transitioning to insulin therapy may affect a patient's ability to agree to and participate in self-management of type 2 diabetes using the prescribed therapy. Current approaches to address reluctance to begin and/or increase insulin therapy are largely educational, using classes and workshops to change attitudes and behavior. Little research exists, however, to determine which factors influence patients' reluctance to use insulin therapy. Therefore, the overall purpose of this study is to identify the factors related to reluctance to initiate insulin therapy (Insulin Reluctance= IR) in individuals with type 2 diabetes. The specific aims are 1) to examine the actual predictors of IR and to describe the relationship among IR in individuals with type 2 diabetes and their sociodemographic, biomedical, and psychosocial factors; and 2) to develop predictive model of IR. To accomplish these aims, a descriptive, correlational, cross-sectional study design will be used. All participants (n=139) will be asked to complete a study questionnaire. Descriptive statistics, uhivariate and bivariate analyses and multiple linear regression will be performed. To describe the relationship among IR, sociodemographic factors, biomedical factors, and psychosocial factors, Pearson correlation coefficients will be computed. To develop a predictive model of IR, multiple linear regression will be conducted. First the overall R-square of the complete model will be examined for significance. If the overall model is significant, the unique contribution of each separate variable in explaining the variance of IR will be tested. Given the significant burden of diabetes, public health care systems are seeking increasingly effective means of providing diabetes care. The proposed study will contribute to knowledge about IR, specifically about more appropriate clinical approaches for health professionals to use in working with type 2 diabetes patients. Thus, health care providers can make the transition to insulin therapy easier and facilitate timely introduction of insulin therapy to achieve optimal glycemic control. Furthermore, study findings may guide more effective educational interventions to reduce psychological barriers to insulin treatment.

描述（由申请人提供）：本培训赠款申请（F31）的目的是提供递载前支持，使该研究人员能够检查与不愿使用2型糖尿病患者使用胰岛素治疗相关的因素。关于过渡到胰岛素治疗的需求的常见误解可能会影响患者同意使用规定疗法同意和参与2型糖尿病的自我管理的能力。当前解决不愿开始和/或增加胰岛素疗法的方法在很大程度上是教育意义的，它使用课堂和研讨会来改变态度和行为。但是，很少有研究可以确定哪些因素会影响患者不愿使用胰岛素治疗。 因此，这项研究的总体目的是确定与不愿启动2型糖尿病患者胰岛素治疗（胰岛素不情愿= IR）有关的因素。具体目的是1）检查IR的实际预测因子，并描述2型糖尿病患者及其社会人口统计学，生物医学和社会心理因素的IR之间的关系； 2）开发IR的预测模型。 为了实现这些目标，将使用描述性，相关，横断面研究设计。所有参与者（n = 139）将被要求填写一份研究问卷。将进行描述性统计，UHIVARIATE和双变量分析以及多个线性回归。为了描述IR，社会人口统计学因素，生物医学因素和心理社会因素之间的关系，将计算Pearson相关系数。为了开发IR的预测模型，将进行多个线性回归。首先，将检查完整模型的整体R平方，以提高意义。如果总体模型很重要，则将测试每个单独的变量在解释IR方差的独特贡献。 鉴于糖尿病的重大负担，公共卫生保健系统正在寻求越来越有效的糖尿病护理手段。拟议的研究将有助于有关IR的知识，特别是关于更合适的临床方法，供卫生专业人员与2型糖尿病患者一起使用。因此，医疗保健提供者可以使人们更容易地过渡到胰岛素治疗，并促进及时引入胰岛素治疗以实现最佳血糖控制。此外，研究结果可能指导更有效的教育干预措施，以减少胰岛素治疗的心理障碍。