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Participation in the Cardiac Dynamics research program organised by Kavli Iinstitute for Theoretical Physics, summer 2006.

参加 Kavli I 理论物理研究所组织的心脏动力学研究项目，2006 年夏季。

基本信息

批准号：
EP/E018548/1
负责人：
Irina Biktasheva
金额：
$ 0.88万
依托单位：
University of Liverpool
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FE018548%2F1
关键词：
Participation Cardiac Dynamics research program

项目摘要

Cardiac disease is a major cause of premature death. More than half ofcardiac disease deaths are sudden and result from a spatiotemporalchaotic wave activity that prevents the main chambers of the heartfrom pumping blood normally (ventricular fibrillation). Developing afundamental understanding of the mechanisms that trigger and maintainlife-threatening cardiac arrhythmias is crucially important fordesigning antiarrhythmic therapies to reduce mortality.Kavli Institute for Theoretical Physics, University of California inSanta Barbara, runs Cardiac Dynamics ``miniprogram'' in the summer 2006. The goal of the program is to bring together aninterdisciplinary group of theorists, experimentalists and clinicianswith common interests in arrhythmogenesis. The program is expected toprovide a unique forum to foster collaborations that will lead to theintegration of new knowledge of biology and nonlinear dynamics inextended media and to the application of this knowledge to controlcardiac arrhythmias and to prevent sudden cardiac death in a clinicalsetting.I am one of 35 participants of the program confirmed to date, and of only 18invited to stay for its full duration. The topics to be covered by theprogram are highly relevant to the above mentioned my two currentlyactive EPSRC projects, GR/D500338/01``Feedback control of resonant drift as a tool for low voltage defibrillation''andEP/D0747891/1 ``Response functions for drift of spiral and scroll waves''.Both of the projects are to bringthe mathematical theory of re-entrant tachycardiacloser to real physiology and clinical applications. The KITP ``Cardiac Dynamics'' research program provides a unique opportunity to meet in a creative environment with world leading experimentalists, informally present and discuss key directions in the area, and formulate interesting problems for further research. The attached invitation from KITP promises to cover part ofmy local expenses, and not any travel expenses. As the invitation came after my most recent grant, EP/D0747891/1, applicationhad been submitted, expenses for the KITP program were notanticipated in either of the existing grant budgets, hence this application.

心脏病是过早死亡的主要原因。超过一半的心脏病死亡是突然的，是由时空混乱的波活动导致的，这种活动阻止了心脏的主要心腔正常泵血(室颤)。对触发和维持危及生命的心律失常的机制有了基本的了解，对于设计抗心律失常疗法以减少死亡率至关重要。加州大学圣巴巴拉分校的卡夫利理论物理研究所于2006年夏天运行心脏动力学“小程序”。该计划的目标是将对心律失常发生有共同兴趣的理论家、实验学家和临床医生组成的跨学科小组聚集在一起。该计划预计将提供一个独特的论坛来促进合作，这些合作将导致在扩展的媒体中整合生物学和非线性动力学的新知识，并将这些知识应用于控制心律失常和防止临床环境中的心脏性猝死。我是该计划迄今已确认的35名参与者之一，只有18名被邀请在整个过程中留下来。该计划所涵盖的主题与我目前正在进行的两个EPSRC项目GR/D500338/01“作为低压除颤工具的谐振漂移的反馈控制”和EP/D0747891/1“螺旋和涡旋波漂移的响应函数”高度相关。这两个项目都是将折返性心动过速的数学理论带入实际的生理学和临床应用。KITP‘’心脏动力学‘’研究计划提供了一个独特的机会，可以在一个创造性的环境中与世界领先的实验者会面，非正式地介绍和讨论该领域的关键方向，并为进一步的研究制定有趣的问题。随信附上的KITP邀请函承诺支付我在当地的部分费用，而不是任何旅行费用。由于邀请是在我最近一次赠款EP/D0747891/1提交之后发出的，因此KITP计划的费用在两个现有的赠款预算中都没有预料到，因此提出了这项申请。