Colloidal Cell Delivery Systems

胶体细胞输送系统

• 批准号: EP/E02078X/1
• 负责人: Brian Saunders
• 金额: $ 10.27万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE02078X%2F1
• 关键词: Colloidal; Cell; Delivery; Systems

As stem cell technologies advance towards clinical application there is an urgent need to enhance the methods of delivering these cells into the body. Current methods of simple injection of cell suspensions are crude because they waste cells, compromise viability and generate poor starting conditions for the regeneration of a tissue. In this collaborative project between the universities of Nottingham and Manchester we will establish an injectable material consisting of a colloid mixture of cells and particles that is injectable at room temperature and aggregates into a porous colloidal gel at body temperature. This material could form the basis for cell delivery in neurology, endocrinology, hepatology, orthopaedics and many other areas because the components are well understood and trusted materials with long track records of use in the body. A successful outcome for this project will prove the principle of cell delivery into skeletal muscle tissue using temperature-triggered assembly and establish the fundamental principles involved.

随着干细胞技术向临床应用的发展，迫切需要改进将这些细胞输送到体内的方法。目前简单注射细胞悬浮液的方法是粗糙的，因为它们浪费细胞，损害生存力并产生用于组织再生的不良起始条件。在诺丁汉和曼彻斯特大学之间的这个合作项目中，我们将建立一种可注射材料，该材料由细胞和颗粒的胶体混合物组成，在室温下可注射，并在体温下聚集成多孔胶体凝胶。这种材料可以成为神经学、内分泌学、肝病学、骨科和许多其他领域细胞输送的基础，因为这些成分是人们熟知的、值得信赖的材料，在体内有着长期的使用记录。该项目的成功结果将证明使用温度触发组装将细胞递送到骨骼肌组织中的原理，并建立所涉及的基本原理。

项目成果

Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single-Step Process

• DOI: 10.1002/adma.200800382
• 发表时间: 2009-05-11
• 期刊: ADVANCED MATERIALS
• 影响因子: 29.4
• 作者: Wang, Wenxin;Liang, He;Alexander, Cameron
• 通讯作者: Alexander, Cameron

Poly(D,L-lactide-co-glycolide) dispersions containing pluronics: from particle preparation to temperature-triggered aggregation.

• DOI: 10.1021/la800869u
• 发表时间: 2008-06
• 期刊: Langmuir : the ACS journal of surfaces and colloids
• 作者: Michael Fraylich;Wenxin Wang;K. Shakesheff;C. Alexander;B. Saunders