Steering Flexible Needles in Soft Tissue

在软组织中引导柔性针

• 批准号: 7483576
• 负责人: Allison Mariko Okamura
• 金额: $ 58.36万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7483576
• 关键词: Ablation; Algorithms; Animals; Biomechanics; Biomedical Engineering; Biopsy; Brain; Cadaver; Cell Therapy; Clinical; Collection; Computer software; Condition; Custom; Development; Devices; Effectiveness; Engineering; Feedback; Fluoroscopy; Goals; Grant; Human body; Image; Imagery; Infection; Intervention; Invasive; Lateral; Life; Liver; Magnetic Resonance Imaging; Methods; Minimally Invasive Surgical Procedures; Modeling; Motion; Needles; Operative Surgical Procedures; Other Agency or Organization; Outcome; Patient Care; Patients; Physicians; Placement; Procedures; Prostate; Public Health; Radiation therapy; Range; Rate; Recovery; Research; Research Personnel; Research Project Grants; Risk; Robotics; Series; Specific qualifier value; Surgeon; System; Techniques; Testing; Therapeutic; Time; Tissue Model; Tissues; To specify; Training; Trauma; Treatment Cost; Ultrasonography; Work; animal tissue; base; chemotherapy; clinical application; design; improved; in vivo Model; model design; models and simulation; novel strategies; preclinical study; programs; prototype; research study; simulation; soft tissue; tissue phantom; tool; tumor

DESCRIPTION (provided by applicant): Minimally invasive surgical techniques have been highly successful in improving patient care, reducing risk of infection, and decreasing recovery times. This project aims to further reduce invasiveness by developing a technique to insert thin, flexible needles into the human body and steer them from outside. This approach will potentially improve a wide range of procedures, from chemotherapy and radiotherapy to biopsy collection and tumor ablation, by enhancing physicians' abilities to accurately maneuver inside the human body without additional trauma to the patient. Building on emerging methods in robotics and highly encouraging results obtained under an R21 exploratory grant, we propose to design, prototype, and evaluate a working system that will steer flexible needles through deformable tissue and around internal obstacles to precisely reach specified 3D targets. This research program will significantly advance our understanding and practice of needle therapies through integrated needle design and modeling, preoperative visualization and needle motion planning, and image-guided intraoperative needle control. The scientific and engineering advances will culminate in a set of pre-clinical trials with imaging (fluoroscopy, ultrasound, and MRI) using phantom and natural ex vivo and in vivo models. The designs, analyses, and experiments of this study will determine the merits and weaknesses of flexible needle steering, with the goals of improving current clinical applications and leading to new ultra-minimally invasive surgical procedures. The results of this project could significantly improve public health by lowering patient recovery times, infection rates, and treatment costs. By increasing the dexterity and accuracy of minimally invasive procedures, anticipated results will not only improve outcomes of existing procedures, but also enable percutaneous procedures for many conditions that currently require open surgery.

描述（由申请人提供）：微创手术技术在改善患者护理、降低感染风险和缩短恢复时间方面非常成功。该项目旨在通过开发一种将细而灵活的针头插入人体并从外部引导它们的技术来进一步减少侵入性。这种方法将潜在地改善从化疗和放疗到活检收集和肿瘤消融的广泛程序，通过增强医生在人体内准确操纵而不对患者造成额外创伤的能力。基于机器人技术的新兴方法和在R21探索性资助下获得的非常令人鼓舞的结果，我们建议设计，原型和评估一个工作系统，该系统将引导柔性针通过可变形组织和内部障碍物，以精确到达指定的3D目标。这项研究计划将通过整合针设计和建模、术前可视化和针运动规划以及图像引导的术中针控制来显著推进我们对针疗法的理解和实践。科学和工程的进步将在一系列使用体模和自然离体和体内模型进行成像（荧光透视、超声和MRI）的临床前试验中达到高潮。本研究的设计、分析和实验将确定柔性针转向的优点和缺点，目的是改进当前的临床应用并导致新的超微创外科手术。该项目的结果可以通过降低患者恢复时间、感染率和治疗成本来显着改善公共卫生。通过增加微创手术的灵活性和准确性，预期的结果不仅将改善现有手术的结果，而且还使目前需要开放手术的许多情况下的经皮手术成为可能。