Systematic Artifact Reduction in Auditory fMRI

听觉 fMRI 中的系统伪影减少

• 批准号: 7344721
• 负责人: THOMAS M TALAVAGE
• 金额: $ 35.5万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7344721
• 关键词: Achievement; Acoustic Stimulation; Acoustics; Affect; Algorithms; Auditory; Auditory area; Behavior; Brain Mapping; Brain Stem; Classification; Communities; Condition; Data; Detection; Discrimination; Echo-Planar Imaging; Financial compensation; Functional Magnetic Resonance Imaging; Future; Generations; Growth; Hearing; Human; Image; Image Analysis; Imaging Techniques; Lead; Location; Magnetic Resonance Imaging; Maps; Masks; Measurement; Measures; Methods; Morphologic artifacts; Neurons; Neurosciences; Noise; Numbers; Operative Surgical Procedures; Pattern; Perception; Physiological; Process; Range; Research; Research Personnel; Rest; Sensory; Slice; Speech; Stimulus; Structure; System; Time; Variant; Visual Cortex; auditory pathway; cognitive function; desire; hemodynamics; image processing; interest; physiologic model; research study; response; tool

Functional magnetic resonance imaging (fMRI) using echo-planar imaging (EPI) results in generation of a systematic confound¿acoustic noise ("acoustic imaging noise")¿that can interfere with the fMRI measurement of cortical activity related to a desired (acoustic) stimulus. Acoustic imaging noise is unavoidably perceived by a hearing subject, leading to neuronal activity throughout the auditory pathway, including cortex. Perception of acoustic imaging noise can alter sensory perception of the desired stimulus¿an alteration that will affect physiologic activity and distort measurement of the hemodynamic response (HDR) to the desired stimulus. Methods, initially directed at auditory fMRI, are proposed to develop correction algorithms that may be used to correct distortions of the "ideal" HDR (that measured in the absence of confound) associated with systematic confounds. Significant benefit to the fMRI community arises from the process by which the correction algorithm is developed, as the process may be applied to other systematic confounds known to be associated with acquisition of fMRI data. The specific aims of this research are summarized as follows: Aim 1: Obtain "ideal" measurements of the HDR to the systematic confound of acoustic imaging noise for blipped-EPI at 1.5T. Aim 2: Obtain non-ideal measurements of HDRs to a desired (acoustic) stimulus, parameterized by variations in the systematic confound (acoustic imaging noise), allowing quantification of interactions between the HDRs. Aim 3: Develop correction algorithms to compensate for distortions present in non-ideal HDR measurements to a desired (acoustic) stimulus, such that resulting HDR estimates resemble those which would be obtained in absence of the systematic confound (acoustic imaging noise). Relevance: Improvements in localization accuracy and detection sensitivity for fMRI experiments conducted in the presence of repeated confounds (e.g., acoustic noise associated with imaging) will allow more precise discrimination of cortical responses to stimuli that may differ only in a subtle fashion. These benefits will provide greater confidence in location and extent of detected activity, significantly impacting human brain mapping, but also directly benefiting efforts at pre-surgical mapping.

使用回波平面成像（EPI）的功能性磁共振成像（fMRI）导致产生一个信号， 系统性混杂声噪声（“声成像噪声”），可能会干扰fMRI测量， 与期望的（声音）刺激有关的皮层活动。声学成像噪声可由 听力受试者，导致整个听觉通路的神经元活动，包括皮层。感知 声学成像噪声可以改变对所需刺激的感官知觉，这种改变将影响生理 活动和失真测量的血液动力学反应（HDR）所需的刺激。方法，首先 针对听觉功能磁共振成像，提出了开发校正算法，可用于校正失真的 与系统性混淆相关的“理想”HDR（在没有混淆的情况下测量）。显著 对功能磁共振成像社区的好处来自于校正算法的开发过程，因为 该过程可以应用于已知与fMRI数据的采集相关联的其他系统性混淆。 本研究的具体目标概述如下： 目的1：获得HDR对声学成像噪声的系统混淆的“理想”测量， 在1.5T时出现脉冲EPI。 目标2：获得对期望的（声学）刺激的HDR的非理想测量，其由以下参数的变化参数化： 系统混杂（声学成像噪声），允许量化HDR之间的相互作用。 目标3：开发校正算法，以补偿非理想HDR测量中存在的失真， 期望的（声学）刺激，使得所得到的HDR估计类似于在不存在的情况下获得的那些 声成像噪声（Acoustic Imaging Noise） 相关性：在美国进行的功能磁共振成像实验的定位准确性和检测灵敏度的提高 重复混淆的存在（例如，与成像相关的声学噪声）将允许更精确的 辨别皮层对刺激的反应，这些反应可能仅以微妙的方式不同。这些好处将提供 在检测到的活动的位置和程度上有更大的信心，显著影响人脑映射，但也 直接受益于术前绘图的工作。