CD8 Mediated Apoptosis During T Cell Development

T 细胞发育过程中 CD8 介导的细胞凋亡

基本信息

  • 批准号:
    7320666
  • 负责人:
  • 金额:
    $ 31.73万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-12-01 至 2009-11-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): During the interaction of T cells with antigen presenting cells (APCs), receptors and intracellular proteins translocate into the contact region known as the Immunological Synapse (IS). In the first Aim we will examine whether CD8 behaves as a coreceptor within the immunological synapse, for the activation of peripheral T cells. In the other component of this proposal we shall follow up on our recent observation that cross-linking of CD8, but not CD4, with antibodies or MHC class I molecules, results in rapid apoptosis of CD4+CD8+ (DP) thymocytes. We have identified the thymocytes that are susceptible to this CD8 mediated apoptosis as an early DP population that expresses low levels of CD2 and CD5 and is CD69-. Treatment with the phorbol ester, PMA, or antibodies to CD3, prevents this induction of apoptosis. We hypothesize that ligation of CD8 by MHC class I molecules in the absence of TCR engagement leads to the death of a subpopulation of early DP thymocytes. Furthermore, our system may provide a model for thymocytes that fail positive selection and are said to undergo "death by neglect". In this proposal we shall further characterize the induction of apoptosis in DP thymocytes by CD8 antibodies and MHC class I molecules according to 3 specific aims: (i) to determine the biochemical events leading to the CD8 mediated death of DP thymocytes; (ii) to determine the mechanism by which treatment with PMA, or engagement of the TCR, prevents CD8 mediated death in DP thymocytes; (iii) to determine whether CD8 mediated death functions under physiological conditions.
描述(由申请人提供):在T细胞与抗原呈递细胞(apc)相互作用期间,受体和细胞内蛋白转运到称为免疫突触(IS)的接触区域。在第一个目标中,我们将研究CD8是否作为免疫突触内的辅助受体,用于激活外周T细胞。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

TERRY A POTTER其他文献

TERRY A POTTER的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('TERRY A POTTER', 18)}}的其他基金

Microscopy
显微镜检查
  • 批准号:
    8311795
  • 财政年份:
    2011
  • 资助金额:
    $ 31.73万
  • 项目类别:
Microscopy
显微镜检查
  • 批准号:
    7663284
  • 财政年份:
    2008
  • 资助金额:
    $ 31.73万
  • 项目类别:
Microscopy
显微镜检查
  • 批准号:
    7188253
  • 财政年份:
    2007
  • 资助金额:
    $ 31.73万
  • 项目类别:
CD8 Mediated Apoptosis During T Cell Development
T 细胞发育过程中 CD8 介导的细胞凋亡
  • 批准号:
    7154097
  • 财政年份:
    2004
  • 资助金额:
    $ 31.73万
  • 项目类别:
CD8 Mediated Apoptosis During T Cell Development
T 细胞发育过程中 CD8 介导的细胞凋亡
  • 批准号:
    6986117
  • 财政年份:
    2004
  • 资助金额:
    $ 31.73万
  • 项目类别:
CD8 in the Immunological Synapse and in Thymocyte Death
CD8 在免疫突触和胸腺细胞死亡中的作用
  • 批准号:
    6780797
  • 财政年份:
    2004
  • 资助金额:
    $ 31.73万
  • 项目类别:
CD8 Mediated Apoptosis During T Cell Development
T 细胞发育过程中 CD8 介导的细胞凋亡
  • 批准号:
    6869103
  • 财政年份:
    2004
  • 资助金额:
    $ 31.73万
  • 项目类别:
INDUCTION OF SPECIFIC IMMUNE TOLERANCE
诱导特异性免疫耐受
  • 批准号:
    6607263
  • 财政年份:
    1999
  • 资助金额:
    $ 31.73万
  • 项目类别:
LISTERIA PROTEINS EFFECTS ON CELL FUNCTION
李斯特菌蛋白质对细胞功能的影响
  • 批准号:
    2672561
  • 财政年份:
    1997
  • 资助金额:
    $ 31.73万
  • 项目类别:
LISTERIA PROTEINS EFFECTS ON CELL FUNCTION
李斯特菌蛋白质对细胞功能的影响
  • 批准号:
    2887056
  • 财政年份:
    1997
  • 资助金额:
    $ 31.73万
  • 项目类别:

相似海外基金

Tri-Signal Artificial Antigen Presenting Cells for Cancer Immunotherapy
用于癌症免疫治疗的三信号人工抗原呈递细胞
  • 批准号:
    10751133
  • 财政年份:
    2023
  • 资助金额:
    $ 31.73万
  • 项目类别:
Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy
用于癌症免疫治疗的微流控精密工程人工抗原呈递细胞
  • 批准号:
    10696138
  • 财政年份:
    2022
  • 资助金额:
    $ 31.73万
  • 项目类别:
The role of microglia as antigen presenting cells in Globoid Cell Leukodystrophy
小胶质细胞作为抗原呈递细胞在球状细胞脑白质营养不良中的作用
  • 批准号:
    10663066
  • 财政年份:
    2022
  • 资助金额:
    $ 31.73万
  • 项目类别:
The role of microglia as antigen presenting cells in Globoid Cell Leukodystrophy
小胶质细胞作为抗原呈递细胞在球状细胞脑白质营养不良中的作用
  • 批准号:
    10537159
  • 财政年份:
    2022
  • 资助金额:
    $ 31.73万
  • 项目类别:
Analysis of the function of antigen-presenting cells present in the stroma of colorectal cancer and the intracellular microbiome
结直肠癌基质中抗原呈递细胞和细胞内微生物组的功能分析
  • 批准号:
    21K08723
  • 财政年份:
    2021
  • 资助金额:
    $ 31.73万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Class II artificial antigen presenting cells for cancer immunotherapy
用于癌症免疫治疗的 II 类人工抗原呈递细胞
  • 批准号:
    10156950
  • 财政年份:
    2021
  • 资助金额:
    $ 31.73万
  • 项目类别:
The role of CX3CR1+ antigen presenting cells in T cell selection and central tolerance"
CX3CR1抗原呈递细胞在T细胞选择和中枢耐受中的作用"
  • 批准号:
    10631854
  • 财政年份:
    2021
  • 资助金额:
    $ 31.73万
  • 项目类别:
Reprogramming Cancer Cells into Antigen Presenting Cells: Cancer Vaccination with mRNA Enabled by Charge-Altering Releasable Transporters
将癌细胞重编程为抗原呈递细胞:通过改变电荷的可释放转运蛋白实现 mRNA 的癌症疫苗接种
  • 批准号:
    10153927
  • 财政年份:
    2021
  • 资助金额:
    $ 31.73万
  • 项目类别:
Class II artificial antigen presenting cells for cancer immunotherapy
用于癌症免疫治疗的 II 类人工抗原呈递细胞
  • 批准号:
    10331830
  • 财政年份:
    2021
  • 资助金额:
    $ 31.73万
  • 项目类别:
Analysis on detrimental interplay between pathogenic helper T cells, inflammatory antigen-presenting cells and disease-associated microglia in chronic pathogenesis of multiple sclerosis
多发性硬化症慢性发病机制中致病性辅助 T 细胞、炎症抗原呈递细胞和疾病相关小胶质细胞之间的有害相互作用分析
  • 批准号:
    20K16294
  • 财政年份:
    2020
  • 资助金额:
    $ 31.73万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了