Dyspnea Outcome Instrument for COPD Research

用于慢性阻塞性肺病研究的呼吸困难结果仪器

• 批准号: 7356810
• 负责人: Anna Migliore Norweg
• 金额: $ 20.98万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7356810
• 关键词: Address; Adult; Affective; Aging; Anxiety; Behavioral; Boston; Breathing; Calibration; California; Characteristics; Chronic; Chronic Obstructive Airway Disease; Classification; Client; Clinical; Clinical Research; Cognition; Cognitive; Communities; Computer Simulation; Computers; Dimensions; Distress; Dyspnea; Dyspnea Management; Education; Emotional; Environmental Risk Factor; Exercise; Factor Analysis; Frequencies; Fright; Funding Opportunities; Future; Health; Healthcare Systems; Hospitals; International; Intervention; Life; Lung; Lung diseases; Measurement; Measures; Medical; Medical center; Mental Depression; Methodology; Methods; Modeling; Multi-Institutional Clinical Trial; Numbers; Outcome; Outcomes Research; Perception; Physiological; Population; Property; Psychometrics; Public Health; Quality of life; Questionnaires; Rate; Recruitment Activity; Rehabilitation therapy; Research; Research Personnel; Sampling; Score; Self Care; Self Efficacy; Services; Shortness of Breath; Structure; Symptoms; Testing; Theoretical model; Training; Universities; Veterans; base; biopsychosocial; coping; desensitization; design; disability; experience; field study; functional status; improved; instrument; programs; prototype; psychologic; psychosocial; response; social; theories

DESCRIPTION (provided by applicant): With the aging of the population, the number of adults living with chronic obstructive pulmonary disease (COPD) is expected to rise significantly. Dyspnea is the most prevalent symptom of COPD contributing to disability. Dyspnea is the perception and experience of labored, uncomfortable breathing influenced by multiple physiological, psychological, social, and environmental factors. Multidimensional dyspnea assessment is an important part of dyspnea management. This study aims to develop and test a prototype computer adaptive test (CAT) version of the Dyspnea Management Questionnaire (DMQ). Advantages of CAT measurement methodology include its greater precision, efficiency and practicality over traditional, fixed-form scales. The 100 item multidimensional DMQ- CAT to be developed in this project will consist of measures of dyspnea intensity, dyspnea-related anxiety, fearful activity avoidance, and self-efficacy for activity. It will address inadequacies in existing COPD-specific scales in efficiently measuring change in the different facets of dyspnea functioning, especially affective, cognitive, and behavioral dimensions, following medical and rehabilitation interventions. The International Classification of Functioning, Disability and Health (ICF) and the Dyspnea Theoretical Model will form the theoretical base of the DMQ-CAT. A cross-sectional design will be used to calibrate and field-test the item pool to be used to build the DMQ-CAT in a target sample of 200 adults with COPD recruited across two hospital settings. The multidimensionality of the item pool will be evaluated using confirmatory factor analysis and item response theory modeling. Its factor structure, internal consistency reliability, and concurrent and discriminate validity will also be evaluated. It will be compared with the UCSD Shortness of Breath Questionnaire, the Chronic Respiratory Disease Questionnaire (CRQ), the Hospital Anxiety and Depression Scale (HADS), and the COPD Self-Efficacy Scale. The accuracy and precision of DMQ-CAT score estimates will be evaluated by comparing them to scores derived from administering the total 100 item pool. Dissemination and future research will focus on using and further testing the DMQ-CAT in multi-site clinical trials in medical, rehabilitation, and community settings. Relevance to Public Health: This study addresses an important need for improved outcome measurement to be used to evaluate the impact of traditional and newly developed medical and rehabilitation interventions that purport to improve dyspnea, function, and quality of life of adults with COPD.Dissemination and future research will focus on using and further testing the DMQ-CAT in multi-site clinical trials in medical, rehabilitation, and community settings. Relevance to Public Health: This study addresses an important need for improved outcome measurement to be used to evaluate the impact of traditional and newly developed medical and rehabilitation interventions that purport to improve dyspnea, function, and quality of life of adults with COPD.

描述（由申请人提供）：随着人口老龄化，患有慢性阻塞性肺病（COPD）的成年人数量预计将显着增加。呼吸困难是导致残疾的慢性阻塞性肺病最常见的症状。呼吸困难是指受多种生理、心理、社会和环境因素影响的呼吸困难、不舒服的感觉和体验。多维呼吸困难评估是呼吸困难管理的重要组成部分。 本研究旨在开发和测试呼吸困难管理问卷 (DMQ) 的原型计算机自适应测试 (CAT) 版本。 CAT 测量方法的优点包括比传统的固定形式秤具有更高的精度、效率和实用性。本项目将开发的 100 项多维 DMQ-CAT 将包括呼吸困难强度、呼吸困难相关焦虑、恐惧活动回避和活动自我效能的测量。它将解决现有慢性阻塞性肺病特定量表在有效测量医疗和康复干预后呼吸困难功能不同方面的变化方面的不足，特别是情感、认知和行为方面的变化。国际功能、残疾和健康分类 (ICF) 和呼吸困难理论模型将构成 DMQ-CAT 的理论基础。 将使用横断面设计来校准和现场测试用于在两家医院机构招募的 200 名慢性阻塞性肺病成人目标样本中构建 DMQ-CAT 的项目库。将使用验证性因素分析和项目响应理论建模来评估项目池的多维性。还将评估其因素结构、内部一致性信度以及并发和区分效度。它将与加州大学圣地亚哥分校呼吸急促问卷、慢性呼吸道疾病问卷 (CRQ)、医院焦虑和抑郁量表 (HADS) 以及慢性阻塞性肺病自我效能量表进行比较。 DMQ-CAT 分数估计的准确性和精确度将通过将其与管理总共 100 个项目池得出的分数进行比较来评估。 传播和未来的研究将侧重于在医疗、康复和社区环境的多地点临床试验中使用和进一步测试 DMQ-CAT。与公共卫生的相关性：本研究解决了改进结果测量的重要需求，用于评估传统和新开发的医疗和康复干预措施的影响，这些干预措施旨在改善 COPD 成人的呼吸困难、功能和生活质量。传播和未来的研究将侧重于在医疗、康复和社区环境中的多地点临床试验中使用和进一步测试 DMQ-CAT。与公共卫生的相关性：本研究解决了改进结果测量的重要需求，用于评估传统和新开发的医疗和康复干预措施的影响，这些干预措施旨在改善慢性阻塞性肺病成人的呼吸困难、功能和生活质量。