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Dyspnea Outcome Instrument for COPD Research

用于慢性阻塞性肺病研究的呼吸困难结果仪器

基本信息

批准号：
7535557
负责人：
Anna Migliore Norweg
金额：
$ 23.61万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-12-01 至 2010-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7535557
关键词：
Address Adult Affective Aging Anxiety Behavioral Boston Breathing Calibration California Characteristics Chronic Chronic Obstructive Airway Disease Classification Client Clinical Clinical Research Cognition Cognitive Computer Simulation Computers Dimensions Distress Dyspnea Dyspnea Management Education Emotional Environmental Risk Factor Exercise Factor Analysis Frequencies Fright Funding Opportunities Future Health Healthcare Systems Hospitals International Intervention Life Lung Lung diseases Measurement Measures Medical Medical center Methodology Methods Modeling Multi-Institutional Clinical Trial Outcome Outcomes Research Perception Physiological Population Property Psychometrics Public Health Quality of life Questionnaires Recruitment Activity Rehabilitation therapy Research Research Personnel Sampling Self Care Self Efficacy Services Shortness of Breath Structure Symptoms Testing Theoretical model Training Universities Veterans base biopsychosocial community setting coping depression desensitization design disability experience field study functional status improved instrument programs prototype psychologic psychosocial response social theories

项目摘要

DESCRIPTION (provided by applicant): With the aging of the population, the number of adults living with chronic obstructive pulmonary disease (COPD) is expected to rise significantly. Dyspnea is the most prevalent symptom of COPD contributing to disability. Dyspnea is the perception and experience of labored, uncomfortable breathing influenced by multiple physiological, psychological, social, and environmental factors. Multidimensional dyspnea assessment is an important part of dyspnea management. This study aims to develop and test a prototype computer adaptive test (CAT) version of the Dyspnea Management Questionnaire (DMQ). Advantages of CAT measurement methodology include its greater precision, efficiency and practicality over traditional, fixed-form scales. The 100 item multidimensional DMQ- CAT to be developed in this project will consist of measures of dyspnea intensity, dyspnea-related anxiety, fearful activity avoidance, and self-efficacy for activity. It will address inadequacies in existing COPD-specific scales in efficiently measuring change in the different facets of dyspnea functioning, especially affective, cognitive, and behavioral dimensions, following medical and rehabilitation interventions. The International Classification of Functioning, Disability and Health (ICF) and the Dyspnea Theoretical Model will form the theoretical base of the DMQ-CAT. A cross-sectional design will be used to calibrate and field-test the item pool to be used to build the DMQ-CAT in a target sample of 200 adults with COPD recruited across two hospital settings. The multidimensionality of the item pool will be evaluated using confirmatory factor analysis and item response theory modeling. Its factor structure, internal consistency reliability, and concurrent and discriminate validity will also be evaluated. It will be compared with the UCSD Shortness of Breath Questionnaire, the Chronic Respiratory Disease Questionnaire (CRQ), the Hospital Anxiety and Depression Scale (HADS), and the COPD Self-Efficacy Scale. The accuracy and precision of DMQ-CAT score estimates will be evaluated by comparing them to scores derived from administering the total 100 item pool. Dissemination and future research will focus on using and further testing the DMQ-CAT in multi-site clinical trials in medical, rehabilitation, and community settings. Relevance to Public Health: This study addresses an important need for improved outcome measurement to be used to evaluate the impact of traditional and newly developed medical and rehabilitation interventions that purport to improve dyspnea, function, and quality of life of adults with COPD.Dissemination and future research will focus on using and further testing the DMQ-CAT in multi-site clinical trials in medical, rehabilitation, and community settings. Relevance to Public Health: This study addresses an important need for improved outcome measurement to be used to evaluate the impact of traditional and newly developed medical and rehabilitation interventions that purport to improve dyspnea, function, and quality of life of adults with COPD.

描述（由申请人提供）：随着人口老龄化，预计患有慢性阻塞性肺疾病（COPD）的成年人数量将显著增加。呼吸困难是导致残疾的COPD最常见的症状。呼吸困难是受多种生理、心理、社会和环境因素影响的吃力、不舒服的呼吸的感知和体验。多维呼吸困难评估是呼吸困难管理的重要组成部分。本研究旨在开发和测试一个原型的计算机自适应测试（CAT）版本的呼吸困难管理问卷（DMQ）。CAT测量方法的优点包括其更高的精度，效率和实用性比传统的，固定形式的规模。本项目将开发的100项多维DMQ-CAT将包括呼吸困难强度、呼吸困难相关焦虑、恐惧活动回避和活动自我效能的测量。它将解决现有COPD专用量表在有效测量呼吸困难功能不同方面的变化方面的不足，特别是在医疗和康复干预后的情感，认知和行为方面。国际功能、残疾和健康分类（ICF）和呼吸困难理论模型将构成DMQ-CAT的理论基础。将使用横断面设计来校准和现场测试项目池，以用于在两个医院环境中招募的200名COPD成年人的目标样本中构建DMQ-CAT。将使用验证性因素分析和项目反应理论模型评估项目库的多维度性。它的因素结构，内部一致性信度，同时和区分效度也将进行评估。将其与UCSD呼吸急促问卷、慢性呼吸系统疾病问卷（CRQ）、医院焦虑抑郁量表（HADS）和COPD自我效能量表进行比较。将通过将DMQ-CAT评分估计值与总计100个项目汇总所得评分进行比较，评价DMQ-CAT评分估计值的准确度和精密度。传播和未来的研究将集中在使用和进一步测试DMQ-CAT在医疗，康复和社区环境的多站点临床试验。与公共卫生的相关性：这项研究解决了一个重要的需求，即改进的结果测量，用于评估传统和新开发的医疗和康复干预措施的影响，旨在改善COPD成人的呼吸困难，功能和生活质量，传播和未来的研究将集中在使用和进一步测试DMQ-CAT在医疗，康复和社区环境的多中心临床试验。与公共卫生的相关性：本研究解决了改善结局测量的重要需求，用于评价传统和新开发的旨在改善COPD成人呼吸困难、功能和生活质量的医疗和康复干预措施的影响。