The role of Wnt-4 signaling during cutaneous wound healing

Wnt-4信号在皮肤伤口愈合中的作用

基本信息

  • 批准号:
    7257079
  • 负责人:
  • 金额:
    $ 10.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-08-01 至 2009-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The goals of this project are to gain insight into the role of Wnt-4 signaling during cutaneous wound healing and to provide the principal investigator, Anne Hocking with the scientific tools and career development necessary for a successful career as independent investigator in the field of wound healing. During the next three years, Dr. Hocking will follow a research career development plan consisting of a program of educational classes in career skills required for an independent researcher and a laboratory based research project under the guidance of a advisory committee comprised of Dr. Frank Isik (Mentor), Dr Randall Moon (Mentor), and Dr. Nicole Gibran (Advisor) at the University of Washington and Dr. William Carter (Advisor) at the Fred Hutchinson Cancer Research Center. Cutaneous wound healing is imperfect in adult mammals. Healed skin lacks epidermal appendages such as hair follicles, sweat and sebaceous glands which can result in problems with thermal regulation and desiccation. Scarring can also be disfiguring, diminish tensile strength and cause contraction which may limit mobility. In addition, abnormal wound healing can cause complications such as hypertrophic scarring and chronic wounds that fail to heal. In order to develop therapies to improve adult wound healing it is necessary to understand the role of cell signaling pathways in the coordination of cell proliferation, migration and biosynthesis of new extracellular matrix during cutaneous wound healing. Therefore, Dr. Hocking proposes to address the functional consequence of the up-regulation of Wnt-4 signaling during wound healing with the following specific aims: 1) determine the temporal and spatial regulation of Wnt-4 expression during cutaneous wound healing; 2) determine if Wnt-4 regulates dermal fibroblast proliferation, migration and biosynthesis of extracellular matrix during cutaneous wound repair; and 3) determine if Wnt-4 regulates keratinocyte proliferation and migration in the cutaneous wound. The significance of this application is that it will improve our understanding of how cell signaling coordinates the cellular processes required for wound healing and may suggest novel therapies to improve adult wound healing.
描述(申请人提供):这个项目的目标是深入了解WNT-4信号在皮肤伤口愈合中的作用,并为首席研究员Anne Hocking提供必要的科学工具和职业发展,使她在伤口愈合领域成为成功的独立研究员。在接下来的三年里,霍金博士将遵循一项研究职业发展计划,该计划包括一名独立研究人员所需的职业技能教育课程计划和一个由华盛顿大学的Frank Isik博士(导师)、Randall Moon博士(导师)和Nicole Gibran博士(顾问)以及弗雷德·哈钦森癌症研究中心的William Carter博士(顾问)组成的顾问委员会的指导下的基于实验室的研究项目。成年哺乳动物的皮肤伤口愈合并不完美。愈合后的皮肤缺少毛囊、汗液和皮脂腺等表皮附属物,这可能会导致温度调节和干燥问题。疤痕还可以毁容,降低抗拉强度,并导致收缩,这可能会限制行动能力。此外,伤口愈合异常会导致肥厚性疤痕和无法愈合的慢性伤口等并发症。为了开发促进成人创面愈合的治疗方法,有必要了解细胞信号通路在皮肤创面愈合过程中协调细胞增殖、迁移和新的细胞外基质生物合成中的作用。因此,Hocking博士建议研究WNT-4信号在创伤愈合过程中上调的功能后果,具体目的如下:1)确定WNT-4在皮肤创伤愈合过程中表达的时空调节;2)确定WNT-4在皮肤创伤修复过程中是否调节真皮成纤维细胞的增殖、迁移和细胞外基质的生物合成;以及3)确定WNT-4是否调节皮肤伤口中角质形成细胞的增殖和迁移。这一应用的意义在于,它将提高我们对细胞信号如何协调伤口愈合所需的细胞过程的理解,并可能为改善成人伤口愈合提供新的治疗方法。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
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Anne Maree Hocking其他文献

Anne Maree Hocking的其他文献

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{{ truncateString('Anne Maree Hocking', 18)}}的其他基金

The role of Wnt-4 signaling during cutaneous wound healing
Wnt-4信号在皮肤伤口愈合中的作用
  • 批准号:
    7472312
  • 财政年份:
    2006
  • 资助金额:
    $ 10.97万
  • 项目类别:
The role of Wnt-4 signaling during cutaneous wound healing
Wnt-4信号在皮肤伤口愈合中的作用
  • 批准号:
    7143443
  • 财政年份:
    2006
  • 资助金额:
    $ 10.97万
  • 项目类别:

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