Administrative Core

行政核心

基本信息

  • 批准号:
    7474413
  • 负责人:
  • 金额:
    $ 7.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-06-01 至 2013-03-31
  • 项目状态:
    已结题

项目摘要

The Administrative Core is essential for the conduct of this Program Project. It will continue to be based in the administrative area of the Hematology-Oncology Division at the University of Pennsylvania. The Core provides administrative support for the participants in the Program Project, as well as secretarial, and consultative functions and the supplies needed to support these functions. In addition, A. Administrative Functions To provide financial coordination for the Program Project, the Core Unit B leader and an experienced business administrator, Ms. Michele Arlotta, monitor the expenditures of each Project and Core Unit, facilitated by a system of computerized record keeping. Project leaders and Core Unit Leaders will be provided with monthly statements of the financial status of their projects or core units. Core Unit B will also serve to centralize the ordering of supplies and equipment, enabling the business administrator to monitor these expenditures and to take advantage of discounted prices available through the University. The business administrator will also oversee matters relating to the consortia with the Division of Hematology at the Children's Hospital of Pennsylvania and Thomas Jefferson University. B. Secretarial functions The Program Project will make use of 35% of the effort of a secretary, Mrs Terese Manganaro, who is based on the 9th floor of BRB 11/111 of the University of Pennsylvania. Mrs. Manganaro will type manuscripts and correspondence generated by the activities of the Program. She has an Apple Macintosh computer and is electronically networked to each investigator via the University of Pennsylvania E-mail network. C. Common Services and Supplies Core Unit B will provide the photocopying, postage, and telephone service needed to support the activities of the Program Project. D. Consultative functions Core Unit B will provide two types of consultative function. First, at monthly intervals, an outside investigator whose interests coincide with those of the members of the Program Project will be asked to a spend a day at the University, meet with the various Project leaders and Co-Investigators, and present a seminar at the weekly Thrombosis & Cardiovascular Biology Seminar. Funds required for these visitors in excess of those requested in the Core Unit Budget will be provided by other funds available to the Hematology-Oncology Division. Second, an External Advisory Committee composed of three members will be selected if and when the Program Project is re-funded. The Committee will be asked to visit the Program Project on a yearly basis, review its progress, and make specific recommendations regarding future directions. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page ,329 Principal Investigator/Program Director (Last, First, Middle): Bennett, Joel S. E. Continued Supply of Monoclonal Antibodies Since the inception of this Program Project, a Hybridoma Core (Core A), has produced a number of monoclonal antibodies (mAbs) to platelet and endothelial glycoproteins that have been highly useful to the Program. These include: A. Monoclonal antibodies to platelets glycoproteins allbfJS. Multiple antibodies have been produced by the Core to platelet allbbS and continue to be extensively utilized. These include mAbs specific for allb; (33; the allb(33 complex; activation-specific epitopes on the allb(33 complex; antiidiotypic mAbs to the activation-specific, anti allbps mAb PAC-1; and the cytoplasmic domains of allb and (33. B. Monoclonal antibodies to the human thrombin receptor (PAR1). The Core has had a particularly productive track-record in producing mAbs to epitopes on amino terminus of human PAR1 that have been useful in studies of platelets and endothelial cells. C. Monoclonal antibodies to the human PAR2. Antibodies to the PAR2 amino terminus (SAM11 and SAM12) have also been generated from mice immunized with the peptide, SLIGKVDGTSHVTG, corresponding to the first 14 residues of human PAR-2 starting at the activation site (Arg36-Ser37). The mAbs have been particularly useful for flow cytometry and immunohistochemical studies. D. Miscellaneous antibodies. Additional antibodies produced by the Core that have been used by Core members include mAbs to CD9 and the chemokine receptor CXCR4. At the renewal for Years 16-20, Core A was not recommended. However, because projects in the Program continued to use the mAbs listed above, funds were restored to enable continuing production of the antibodies. In this application, we have not proposed the production of new mAbs within the Program and have not requested continuation of Core A. But all of the project continue to make extensive use of one or more of these mAbs and therefore, we have requested modest partial salary support for a Research Specialist to produce them. Costs for supplies will be charged to individual projects as necessary. Although the Research Specialist does not perform an "administrative" function, she does perform a Program-wide function and we think Core B would be the most appropriate place to request support for her salary.
行政核心对本计划项目的实施至关重要。它将继续如此

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Joel S. Bennett其他文献

Effects of Load and Contact Time on the Stability of Bimolecular Integrin-Fibrinogen Bonds Under a Constant Tensile Force
  • DOI:
    10.1016/j.bpj.2008.12.3113
  • 发表时间:
    2009-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Rustem I. Litvinov;Joel S. Bennett;John W. Weisel;Henry Shuman
  • 通讯作者:
    Henry Shuman
Effect of Deletion of Glycoprotein lib Exon 28 on the Expression of the Platelet Glycoprotein IIb/IIIa Complex
  • DOI:
    10.1182/blood.v78.9.2344.2344
  • 发表时间:
    1991-11-01
  • 期刊:
  • 影响因子:
  • 作者:
    Michael A. Kolodziej;Gaston Vilaire;Salahaldin Rifat;Mortimer Poncz;Joel S. Bennett
  • 通讯作者:
    Joel S. Bennett
Disorders of platelet function: evaluation and treatment.
血小板功能障碍:评估和治疗。
A Collaborative Filtering Recommender using SOM clustering on Keywords Joel Bennett November
对关键字使用 SOM 聚类的协作过滤推荐器 Joel Bennett 十一月
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Joel S. Bennett
  • 通讯作者:
    Joel S. Bennett
Effect of Single Amino Acid Substitutions on the Formation of the PI<sup>A</sup> and Bak Alloantigenic Epitopes
  • DOI:
    10.1182/blood.v78.3.681.681
  • 发表时间:
    1991-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Amy Goldberger;Michael Kolodziej;Mortimer Poncz;Joel S. Bennett;Peter J. Newman
  • 通讯作者:
    Peter J. Newman

Joel S. Bennett的其他文献

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{{ truncateString('Joel S. Bennett', 18)}}的其他基金

Platelet Integrin Structure and Function
血小板整合素结构和功能
  • 批准号:
    10161822
  • 财政年份:
    2020
  • 资助金额:
    $ 7.02万
  • 项目类别:
Admin core for the Studies of Physiologic and Pathologic Platelet Plug Formation
生理和病理血小板栓形成研究的管理核心
  • 批准号:
    10656285
  • 财政年份:
    2020
  • 资助金额:
    $ 7.02万
  • 项目类别:
Platelet Integrin Structure and Function
血小板整合素结构和功能
  • 批准号:
    10434810
  • 财政年份:
    2020
  • 资助金额:
    $ 7.02万
  • 项目类别:
Admin core for the Studies of Physiologic and Pathologic Platelet Plug Formation
生理和病理血小板栓形成研究的管理核心
  • 批准号:
    10161820
  • 财政年份:
    2020
  • 资助金额:
    $ 7.02万
  • 项目类别:
Admin core for the Studies of Physiologic and Pathologic Platelet Plug Formation
生理和病理血小板栓形成研究的管理核心
  • 批准号:
    10434808
  • 财政年份:
    2020
  • 资助金额:
    $ 7.02万
  • 项目类别:
Platelet Integrin Structure and Function
血小板整合素结构和功能
  • 批准号:
    10656292
  • 财政年份:
    2020
  • 资助金额:
    $ 7.02万
  • 项目类别:
Structure and Function of the Platelet Integrin
血小板整合素的结构和功能
  • 批准号:
    7474406
  • 财政年份:
    2008
  • 资助金额:
    $ 7.02万
  • 项目类别:
Mechanisms of normal and abnormal platelet homeostasis
正常和异常血小板稳态的机制
  • 批准号:
    7406856
  • 财政年份:
    2006
  • 资助金额:
    $ 7.02万
  • 项目类别:
Mechanisms of normal and abnormal platelet homeostasis
正常和异常血小板稳态的机制
  • 批准号:
    7808883
  • 财政年份:
    2006
  • 资助金额:
    $ 7.02万
  • 项目类别:
Mechanisms of normal and abnormal platelet homeostasis
正常和异常血小板稳态的机制
  • 批准号:
    6951697
  • 财政年份:
    2006
  • 资助金额:
    $ 7.02万
  • 项目类别:

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