Administrative and Mouse Management Core

概况.与以前一样，该核心由两部分组成： 一般管理组件和鼠标管理组件。 一般行政组成部分的工作是保持整个方案的凝聚力， 通过组织小组会议、务虚会和期刊俱乐部，以及处理任何和所有的内部事务， 出现的部门或机构问题。它还组织对该计划的内部和外部审查， 并确保及时提交续期申请。它定期跟踪 每月提供项目的财务状况，并协助解决招聘和其他人事问题。在 此外，核心确定新出版的文献有关的计划，并分发给 项目中的合适的研究人员。行政部门的目标是确保 整个程序尽可能有效和最佳地运行。 小鼠管理组件支持1名全职和1名兼职动物技术员。这些 经过全面培训并从事基因靶向和转基因小鼠维护的个人 在个别项目中提出的模型。该组件具有必要的设备和空间 无病原体的小鼠特异性动物园，如下所述。新鼠标模型的实际生产将在 通过目前建立的UCSD转基因小鼠和胚胎干细胞基因靶向 核心，请参阅http://cancer.ucsd.edu/Research/Shared/tgm/default2.asp。这个最先进的设施 最初是在J.马斯（项目1负责人）的大力支持和建议下开始的， 在生产转基因小鼠方面有着出色的记录。因此，与其进行基因靶向， 我们自己，现在这个计划通过收费服务来支付老鼠的一代是有意义的， 这是UCSD的核心。虽然总成本大致相同，但我们避免了 机构。由于我们过去使用这种方法的经验是好的，我们决定在2010年继续使用这种方法。 目前的提案。 预算方法：根据我们迄今为止的经验，我们也认为最好保持日常管理 和饲养小鼠，所涉及的动物技术人员，鼠笼空间的成本，以及 将这样的速度同源性（见下文）作为核心功能-而不是将资源分配给每个 这些活动的项目。这一做法还允许最大限度地灵活适应以下方面的需要： 所有的项目，每年都会有所不同。虽然这使得一个相当大的预算， “行政核心”，大部分预算实际上是用于与老鼠有关的费用。行政部分 预算仍然与以前的赠款版本基本相同。

Overview. As before, this Core consists of two components: A General Administrative Component, and a Mouse Management Component. The General Administrative Component works to maintain the cohesiveness of the whole program and its functions by organizing group meetings, retreats and journal clubs, and by dealing with any and all inter- Departmental or Institutional issues that arise. It also organizes internal and external reviews of the program, as well as making sure that renewal applications are submitted in a timely fashion. It regularly tracks the financial status of the program on a monthly basis, and assists in hiring and other personnel issues. In addition, the Core identifies newly published literature relevant to the program, and distributes to the appropriate investigators within the program. The goal of the administrative component is to make certain that the entire program functions as efficiently and optimally as possible. The Mouse Management Component supports 1 full time and one part-time animal technician. These individuals who are fully trained and engaged in the maintenance of gene-targeted and transgenic mouse models proposed in the individual projects. This component has the necessary equipment and space in a pathogen-free mouse-specific vivarium, as detailed below. The actual production of new mouse models will be done through the currently established UCSD Transgenic Mouse and Embryonic Stem Cell Gene Targeting Core, please see http://cancer.ucsd.edu/Research/Shared/tgm/default2.asp. This state-of-the-art facility was originally started with major support and advice from J. Marth (Project 1 leader) and has since developed an excellent track record in the production of genetically altered mice. Thus, rather than doing gene targeting ourselves, it now makes sense for this program to pay via fee-for-service for the generation of mice through this established UCSD Core. While the total costs are about the same, we avoid duplicative functions at the institution. Since our past experience with this approach has been good, we have decided to continue it in the current proposal. Budgetary Approach: Based on our experience to date, we also feel it is best to keep the daily management and breeding of mice, the animal technicians involved, the costs of mouse cage space, and the use of approaches such a Speed Congenics (see below) as a Core function - rather than allocating resources to each project for these activities. This approach also allows the maximum flexibility in accommodating the needs of all the projects, which will vary from year to year. While this makes for a rather large budget for an "Administrative Core", most of the budget is actually for mouse-related costs. The administrative component budget remains very much the same as in the previous version of the grant.