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Ets transcription factors in intestinal biology

肠道生物学中的 Ets 转录因子

基本信息

批准号：
7430450
负责人：
PAUL JEDLICKA
金额：
$ 13.58万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7430450
关键词：
Accounting Adult Affect Animals Binding Biological Biological Models Biological Process Biology Cell Communication Cell Proliferation Cells Cessation of life Chemical Agents Chromosomes Colon Colon Carcinoma Complex Condition Control Animal Data Development Disease Disruption Dominant-Negative Mutation Embryonic Development Enterocolitis Environment Epithelial Epithelial Neoplasms Epithelium Exhibits Family Functional disorder Genetic Genus Cola Growth Human Impairment Infection Inflammation Inflammatory Bowel Diseases Injury Intestinal Neoplasms Intestines Investigation Learning Life Maintenance Malignant Neoplasms Mediating Mitolactol Morphogenesis Mus Natural regeneration Neoplasms Neoplastic Cell Transformation Numbers Nutrient Organ Organism Pathologic Pathway interactions Phenotype Physiological Play Pongidae Premalignant Process Protein Family Protein Overexpression Proteins Publishing RNA Research Design Research Personnel Reverse Transcriptase Polymerase Chain Reaction Role Signal Transduction Small Intestines Sodium Dextran Sulfate Source Staining method Stains Structure Surface System Tetracycline Control Tissues Trans-Activators Transgenes Transgenic Mice Tumor Burden Type I Epithelial Receptor Cell VP 16 Villus Woman absorption adenoma base body system cell growth cell motility design extracellular in vivo intestinal crypt intestinal epithelium intestinal villi malformation member men mouse model neoplastic pressure programs promoter response response to injury self-renewal transcription factor transgene expression villin

项目摘要

DESCRIPTION (provided by applicant): The intestine is a complex and dynamic organ that, under normal physiologic conditions, performs a number of functions in the organism, some of which, including nutrient absorption, are essential for survival. The intestine is subject to pathologic disturbances in a number of diseases affecting humans, including developmental malformations, inflammatory bowel disease (affecting 1 million people in the US each year), and cancer, including colon cancer (which accounts for 10% of cases of cancer and 10% of deaths from cancer in men and women each in the US each year). Members of the Ets transcription factor family are important regulators of pathways that mediate cell growth, differentiation, and interactions between cells and the surrounding environment. There is evidence that Ets factors are important in the formation and normal function of the intestine, in intestinal injury, such as occurs in inflammatory bowel disease, and in intestinal (colon) cancer. The long-term objectives of the proposed studies are to elucidate how Ets factors impact these processes. We have developed an animal (mouse) model system designed to block or enhance Ets factor function in the developing and adult intestine in the living organism. We now propose to use this model system to characterize how Ets factors regulate the formation and maintenance of the functional unit of the intestine (the so-called "crypt-villus axis") under normal conditions and conditions of intestinal injury, as well as how they regulate the initiation and/or progression of intestinal (colon) cancer. As the studies will be conducted in a mouse model system, in which intestinal structure and function are extremely similar to those in humans, it is expected that the information learned will have direct relevance to the understanding of normal intestinal function and disease, including inflammatory bowel disease and colon cancer, both prevalent diseases causing significant suffering and death, in humans.

描述（由申请人提供）：