Biostatistics for Research in Environmental Health

环境健康研究生物统计学

• 批准号: 7459511
• 负责人: AMY H HERRING
• 金额: $ 118.57万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7459511
• 关键词: Biometry; Environmental Health; Research

DESCRIPTION (provided by applicant) This 5-year program is designed to train predoctoral (Ph.D.) students and postdoctoral fellows in three distinct but related areas: Environmental Biostatistics (BIOS), Environmental Epidemiology (EPID), and Environmental Exposure Assessment (ENVR). The interdisciplinary goal of this training program is to prepare scientists to address emerging challenges in environmental health research, with an emphasis on the development of tools for harnessing the rich and high-dimensional information that is now routinely available. The overarching goal is to improve the understanding of effects of environmental and other exposures, such as diet and physical activity, in order to impact public health through prevention and better clinical care. Increasingly, we need scientists with strong skills in statistics, epidemiology and basic science, along with an ability to understand and translate the clinical implications of their findings. A critical component is a better understanding of heterogeneity among individuals in environmental effects through the creative use of emerging technologies for measuring gene expression, levels of metabolites, and single nucleotide polymorphisms across the genome. Along with detailed measures of environmental exposures, these tools allow careful study of gene by environment interaction, which has great clinical importance, as interventions may be increasingly driven by genetic factors in order to optimize efficacy. The BIOS goal is to train biostatisticians in general statistical methods, including new approaches for analyzing and visualizing very high-dimensional data. In addition, a focus will be on use of methods motivated by the biology, allowing integration of data from multiple sources. The EPID goal is to train scientists in conducting studies of environmental effects, fully utilizing and understanding the statistical and technological tools available, while also addressing the translational goals described above. The ENVR goal is to train environmental scientists to conduct research on biological and statistical methods for assessing environmental exposures as they relate to human health effects. The typical pre-doctoral trainee will have a Bachelor's or Master's degree with an excellent academic record appropriate for one of the three training areas, and the typical postdoctoral trainee will have highly relevant doctoral training. Funding is requested for the support of 20 pre-doctoral trainees for each of 5 years (8 BIOS, 6 EPID, 6 ENVR) and for 8 postdoctoral trainees (2 BIOS, 3 EPID, 3 ENVR). The Departments of Biostatistics, Epidemiology, and Environmental Sciences and Engineering, the three largest and most recognized departments in the 2nd-ranked UNC School of Public Health, have available all the personnel and facilities sufficient to provide comprehensive pre-doctoral and postdoctoral training. BACKGROUND This proposal is a competing continuation of a large, established, and successful training program spanning three different departments and covering three areas: environmental biostatistics, environmental epidemiology, and environmental exposure assessment. The program has been very successful in training and placing successful researchers in academic, government, industry, and consulting positions in each of the three areas. The program has been in place for 35 years and continually funded for the last 29 years. The proposed program reduces the number of pre-doctoral trainees from thirty in 2005-2006 to twenty and increases the number of postdoctoral trainees from four in 2005-2006 to eight.

描述(由申请人提供) 这个为期5年的项目旨在培养博士前(博士)。学生和博士后研究员在三个不同但相关的领域：环境生物统计学(BIOS)、环境流行病学(EPID)和环境暴露评估(ENVR)。这一培训计划的跨学科目标是让科学家做好准备，以应对环境健康研究中新出现的挑战，重点是开发工具，利用现在经常可以获得的丰富和高维度的信息。总体目标是提高对环境和其他暴露的影响的了解，例如饮食和体力活动，以便通过预防和更好的临床护理影响公众健康。我们越来越需要在统计学、流行病学和基础科学方面有很强技能的科学家，以及理解和翻译他们的发现的临床含义的能力。一个关键的组成部分是通过创造性地使用新兴技术来测量基因组中的基因表达、代谢物水平和单核苷酸多态，从而更好地了解环境影响中个体之间的异质性。随着环境暴露的详细措施，这些工具可以仔细研究基因与环境的相互作用，这具有非常重要的临床意义，因为干预措施可能越来越多地受到遗传因素的驱动，以优化疗效。 基本输入输出系统的目标是培训生物统计学家掌握一般的统计方法，包括分析和可视化高维数据的新方法。此外，重点将放在以生物学为动力的方法的使用上，允许整合来自多个来源的数据。EPID的目标是培训科学家进行环境影响研究，充分利用和理解现有的统计和技术工具，同时也解决上述翻译目标。环境研究和研究中心的目标是培训环境科学家，研究评估环境暴露对人类健康影响的生物学和统计学方法。 典型的博士后实习生将拥有学士或硕士学位，并拥有与三个培训领域之一相适应的优秀学术记录，典型的博士后实习生将接受高度相关的博士培训。要求提供资金，用于在5年内每年支助20名博士后实习生(8名基本输入输出系统、6个EPID、6个ENVR)和8个博士后培训生(2个基本输入输出系统、3个EPID、3个ENVR)。生物统计学、流行病学和环境科学与工程学系是北卡罗来纳大学公共卫生学院中最大和最受认可的三个系，它们拥有足够的人员和设施，足以提供全面的博士前和博士后培训。 背景 这项建议是一个大型的、成熟的、成功的培训计划的竞争延续，该计划横跨三个不同的部门，涵盖三个领域：环境生物统计学、环境流行病学和环境暴露评估。该计划在培训和安排成功的研究人员担任这三个领域的学术、政府、行业和咨询职位方面取得了非常成功的成就。该计划已经实施了35年，并在过去的29年里持续提供资金。拟议的计划将博士后实习生人数从2005-2006年的30人减少到20人，并将博士后实习生人数从2005-2006年的4人增加到8人。