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Impact of Genetic Manipulation of PKD1 on Renal Development and Cystic Disease

Impact of Genetic Manipulation of PKD1 on Renal Development and Cystic Disease
PKD1 基因操作对肾脏发育和囊性疾病的影响
批准号：
7499417
负责人：
PATRICIA D. WILSON
金额：
$13.14万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-08-01 至 2008-07-31
来源：
https://reporter.nih.gov/project-details/7499417
关键词：
3-DimensionalAdherens JunctionAdhesionsAdolescentAdultAllelesAutosomal Dominant Polycystic KidneyAutosomal Recessive Polycystic KidneyBindingBiologicalBiological AssayBirthCell AdhesionCell LineCell Proliferation RegulationCell membraneCellsCollagenComplexCultured CellsCystCystic Kidney DiseasesDataDependovirusDevelopmentDilatation - actionDiseaseEffectivenessEmbryonic DevelopmentEnsureEpithelial CellsEpitheliumFocal Adhesion Kinase 1Focal AdhesionsGelGene DeliveryGene ExpressionGene MutationGene SilencingGenesGeneticGenetic TranscriptionHereditary DiseaseHumanImmigrationIntegrinsKidneyKidney DiseasesKidney FailureLifeMembrane ProteinsMetanephric DiverticulumMicroinjectionsModelingMolecularMorphogenesisMultiprotein ComplexesMusMutant Strains MiceMutationNephronophthisisOrgan Culture TechniquesPathological DilatationPathway interactionsPenetrancePhenotypePolycystic Kidney DiseasesProtein OverexpressionProteinsRegulationRepressionRoleSRC geneSeriesSignal PathwaySignal TransductionSignal Transduction PathwayStagingStructureTestingTherapeutic InterventionTimeTissuesTransfectionTransgenic MiceTransgenic OrganismsVinculinadeno-associated viral vectorbasebasolateral membranecell motilitycollecting tubule structuredesignexpression vectorfetalgene therapygenetic manipulationhuman BCAR1 proteinkidney cellloss of function mutationmanmigrationmouse modelmutantnephrogenesisnovel therapeuticspaxillinpolycystic kidney disease 1 proteinpostnatalprogramspromoterprotein functionrecombinaseresearch studytensintissue/cell culture

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