Impact of Genetic Manipulation of PKD1 on Renal Development and Cystic Disease

PKD1 基因操作对肾脏发育和囊性疾病的影响

• 批准号: 7499417
• 负责人: PATRICIA D. WILSON
• 金额: $ 13.14万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7499417
• 关键词: 3-Dimensional; Adherens Junction; Adhesions; Adolescent; Adult; Alleles; Autosomal Dominant Polycystic Kidney; Autosomal Recessive Polycystic Kidney; Binding; Biological; Biological Assay; Birth; Cell Adhesion; Cell Line; Cell Proliferation Regulation; Cell membrane; Cells; Collagen; Complex; Cultured Cells; Cyst; Cystic Kidney Diseases; Data; Dependovirus; Development; Dilatation - action; Disease; Effectiveness; Embryonic Development; Ensure; Epithelial Cells; Epithelium; Focal Adhesion Kinase 1; Focal Adhesions; Gel; Gene Delivery; Gene Expression; Gene Mutation; Gene Silencing; Genes; Genetic; Genetic Transcription; Hereditary Disease; Human; Immigration; Integrins; Kidney; Kidney Diseases; Kidney Failure; Life; Membrane Proteins; Metanephric Diverticulum; Microinjections; Modeling; Molecular; Morphogenesis; Multiprotein Complexes; Mus; Mutant Strains Mice; Mutation; Nephronophthisis; Organ Culture Techniques; Pathological Dilatation; Pathway interactions; Penetrance; Phenotype; Polycystic Kidney Diseases; Protein Overexpression; Proteins; Regulation; Repression; Role; SRC gene; Series; Signal Pathway; Signal Transduction; Signal Transduction Pathway; Staging; Structure; Testing; Therapeutic Intervention; Time; Tissues; Transfection; Transgenic Mice; Transgenic Organisms; Vinculin; adeno-associated viral vector; base; basolateral membrane; cell motility; collecting tubule structure; design; expression vector; fetal; gene therapy; genetic manipulation; human BCAR1 protein; kidney cell; loss of function mutation; man; migration; mouse model; mutant; nephrogenesis; novel therapeutics; paxillin; polycystic kidney disease 1 protein; postnatal; programs; promoter; protein function; recombinase; research study; tensin; tissue/cell culture