Role of Phosphorylation of Polycystin-1 in Renal Development and ADPKD

Polycystin-1 磷酸化在肾脏发育和 ADPKD 中的作用

• 批准号: 7501812
• 负责人: PATRICIA D. WILSON
• 金额: $ 13.14万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7501812
• 关键词: Adherens Junction; Adhesions; Adult; Affect; Amino Acids; Apical; Area; Autosomal Dominant Polycystic Kidney; Binding; Biochemical; Biological Assay; Birth; C-terminal; Cell Line; Cell Nucleus; Cell Proliferation; Cell physiology; Cells; Cellular Structures; Condition; Critical Pathways; Cyclic AMP-Dependent Protein Kinases; Cyst; Defect; Development; Disease Progression; Drug Design; Environment; Epithelial Cell Proliferation; Epithelial Cells; Epithelium; Extracellular Matrix; Focal Adhesion Kinase 1; Focal Adhesions; Gene Expression; Gene Mutation; Genes; Genetic Transcription; Goals; Growth Factor; Hereditary Disease; Human; Incidence; Integrins; Kidney; Kidney Failure; Lateral; Lead; Length; Maps; Mediating; Membrane; Membrane Proteins; Metanephric Diverticulum; Molecular; Morphogenesis; Multiprotein Complexes; Mutation; N-terminal; Onset of illness; PKD1 gene; PTK2 gene; Pathway interactions; Phosphorylation; Phosphorylation Site; Physical Dialysis; Polycystic Kidney Diseases; Proline; Protein Kinase; Proteins; Rate; Recruitment Activity; Regulation; Renal Replacement Therapy; Renal function; Renal tubule structure; Reporter; Research Design; Research Personnel; Role; SRC gene; Serine; Signal Transduction; Site; Structure; Symptoms; Talin; Testing; Therapeutic; Transcript; Transduction Gene; Translating; Transmembrane Domain; Transplantation; Tyrosine; Vinculin; design; disease phenotype; extracellular; fetal; hydropathy; in utero; insight; migration; mutant; novel therapeutics; paxillin; polycystic kidney disease 1 protein; prevent; programs; protein function; protein protein interaction; small molecule; therapeutic target; tool