Multi-modal optical imaging applied to robot-assisted endoscopy (MOIRE)

多模态光学成像应用于机器人辅助内窥镜检查（MOIRE）

• 批准号: EP/E06342X/1
• 负责人: Daniel Elson
• 金额: $ 35.95万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE06342X%2F1
• 关键词: Multi; modal; optical; imaging; applied

Over the past fifteen years the strong and complex interaction of light and tissue has begun to be exploited in clinical applications for the diagnosis of disease. The absorption, scattering, reflection and fluorescence properties can provide a live signal to reveal metabolic and morphologic changes in the epithelium and stroma associated with the development of pre-cancer. The potential increase in diagnostic specificity through multi-modal and multi-spectral imaging may reduce the number of unnecessary biopsies and reduce the delay to intervention, improving the current slow and inefficient white light screening procedures. During the same time period, there has also been a revolution in surgical technology through the widespread use of minimally invasive surgical (MIS) techniques and the development of sophisticated human-controlled surgical robots, which allow the performance of procedures that are otherwise prohibited by the confines of the operating environment. Currently, the surgical navigation for these procedures is based on white light reflected video images acquired from conventional or stereoscopic endoscopes, giving a limited view of the tissue that only reports tissue colour, shape and texture. The purpose of this project is to develop a multimodal optical visualisation technique that permits in situ, in vivo imaging of complex anatomical and functional information of the operating field and integrate this into robot assisted surgery for safer and more effective surgical navigation and diagnosis.

在过去的十五年里，光和组织的强烈而复杂的相互作用已经开始被用于疾病诊断的临床应用。它们的吸收、散射、反射和荧光特性可以提供实时信号，揭示与癌前病变相关的上皮和间质的代谢和形态变化。通过多模式和多光谱成像可能提高诊断的特异性，可能会减少不必要的活检次数，减少干预的延迟，改善目前缓慢和低效的白光筛查程序。在同一时期，外科技术也发生了一场革命，广泛使用微创外科技术(MIS)和开发复杂的人类控制的外科机器人，这些机器人允许执行原本因手术环境的限制而被禁止的程序。目前，这些手术的手术导航是基于从传统或立体内窥镜获得的白光反射视频图像，提供了有限的组织视野，仅报告组织颜色、形状和质地。该项目的目的是开发一种多模式光学可视化技术，允许对手术领域的复杂解剖和功能信息进行原位、活体成像，并将其集成到机器人辅助手术中，以实现更安全和更有效的手术导航和诊断。

项目成果

Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

• DOI: 10.1117/1.jbo.21.10.106006
• 发表时间: 2016-10-01
• 期刊: JOURNAL OF BIOMEDICAL OPTICS
• 影响因子: 3.5
• 作者: Clancy, Neil T.;Saso, Srdjan;Elson, Daniel S.
• 通讯作者: Elson, Daniel S.

A tunable supercontinuum laser using a digital micromirror device

使用数字微镜装置的可调谐超连续谱激光器

• DOI: 10.1088/0957-0233/23/10/105204
• 发表时间: 2012
• 期刊: Measurement Science and Technology
• 影响因子: 2.4
• 作者: Wood T

Towards intra operative diagnosis of mesenteric tissue oxygenation with hyperspectral imaging

高光谱成像术中诊断肠系膜组织氧合

• 发表时间: 2010
• 作者: Daniel Elson

Multi-excitation fluorescence spectroscopy for analysis of non-alcoholic fatty liver disease.

用于分析非酒精性脂肪肝疾病的多激发荧光光谱。

• DOI: 10.1002/lsm.21064
• 发表时间: 2011
• 期刊: Lasers in surgery and medicine
• 影响因子: 2.4
• 作者: Sauvage VR

Development of a Polarised Endoscopic Hyperspectral Reflection and Fluorescence Imaging System (invited)

偏振内窥镜高光谱反射和荧光成像系统的研制（特邀）

• 发表时间: 2009
• 作者: Daniel Elson