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Reconfigurable 3D Origami Probes for Multi-modal Neural Interface

用于多模态神经接口的可重构 3D 折纸探针

基本信息

批准号：
10738994
负责人：
GYORGY BUZSAKI
金额：
$ 383.76万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10738994
关键词：
3-Dimensional Address Adhesives Affect Alloys Amplifiers Animals Applications Grants Area Biochemical Brain Brain region Chronic Custom Data Detection Development Devices Dopamine Electrodes Electrophysiology (science)Ensure Fiber Fiber Optics Goals Hormones Letters Magnetism Measures Metabolism Methods Mission Modality Monitor Nature Neuromodulator Neurons Neurosciences Neurotransmitters Noise Optics Pattern Photometry Physiological Polymers Positioning Attribute Process Records Regulation Reporting Resolution Rodent Sampling Scheme Signal Transduction Silicon Site Specificity Surface Tension Techniques Technology Temperature Testing Thinness Time Validation Variant Work aqueous awake cell type density design electric impedance experimental study fabrication flexibility in vivo innovation integrated circuit magnetic field multimodality neural neural circuit neurotechnology neurotransmission novel operation optical fiber programs prototype sensor technology platform tool tool development

项目摘要

Project Summary Over the decades, various neurotechnologies have made significant advancements to meet the highest priority goals enumerated in the BRAIN 2025 Report. However, each tool development has been driven by a certain type of specific modalities in the target brain region, cell type, and limited experiments and has focused on scaling in a narrow domain. While the utility of such tools has uniquely served one modality, neuroscience experiments are inherently limited by the breadth of observations available. It is known that brain activities and status are affected by biophysiological parameters such as metabolism, hormones, neurotransmitters, temperature regulation, etc. However, as of yet, neurotechnology tools have not been combined to simultaneously measure multiple signals in a single experiment. This grant application proposes a reconfigurable neural interface platform on which multi-modal probes can be seamlessly integrated on the same flexible substrate to substantially enhance observational breadth. The proposed tool offers multi-modal capabilities by adding physio-bio-chemical sensor modules to the basic key electrophysiological functions of high-density neural recording and target-specific modulation of neurons. Each sensor module can be easily integrated into the existing modalities as an “additive” option, not a “replacing” alternative. The proposed platform is highly reconfigurable to meet the needs by pick-and-choose the desired modality for target studies and experiments. By modularizing and combing single-modality flexible probes, the proposed scheme can provide a highly efficient solution to the challenges in the comprehensive integration of multi-modality on the same platform. Preliminary Data: The previous work has demonstrated the feasibility of neuron-sized μLEDs (15 μm x 10 μm) monolithically integrated on silicon recording probes, precisely positioned relative to the recording sites. Prototype probes incorporated 256 recording sites and 128 μLEDs. Recently, we integrated the μLEDs on a flexible polymer substrate and stacked them with a recording probe. Initial feasibility was demonstrated for sensing dopamine and local brain temperature in-vivo from the flexible probes. Specific Aims: In aim 1, self-aligned flexible 3D origami probes will be developed for diverse neural interfaces with multiple modalities. Two prototype platforms will be developed: One is planar, stacked multi-modal probes with all electrical interfaces, and the other is 3D origami probes wrapped around an optical fiber that will give additional opto-modality such as photometry. In aim 2, a modular, compact headstage will be developed utilizing an innovative adaptable cable-on-chip assembly with custom ICs as an interposer. In aim 3, validation of the proposed multi-modal origami probes will be conducted in chronic rodent experiments.

项目总结