Synthetic Applications of Catalytic Ruthenium Complexes

Whittlesey和威廉姆斯小组以前的研究已经确定了非常活跃的催化剂，用于涉及氢加成和氢去除的反应。这些催化剂将用于开发新的反应，包括氢加成和氢去除，以制备有用的有机产品。特别地，不需要正式氧化剂的醇的氧化提供了使用常规氧化剂的环境友好的替代方案。该化学方法还将用于合成酰胺的新方法，酰胺广泛存在于天然产物和药物化合物中。钌配合物的高反应性将用于将含硝基和腈的化合物转化为胺。由于含硝基和腈基的化合物在C-C键形成反应中是有用的，这为合成广泛的胺提供了强有力的方法学。借氢化学的原理将发展到杂环和复杂生物碱的合成，并扩展到手性控制的化合物的形成

Previous research from the Whittlesey and Williams groups has identified very active catalysts for reactions involving hydrogen addition and hydrogen removal. These catalysts will be used for the development of new reactions involving hydrogen addition and hydrogen removal to prepare useful organic products. In particular, the oxidation of alcohols without the need for a formal oxidant provides an environmentally-friendly alternative to the use of conventional oxidising agents. The chemistry will also be used for a new approach to the synthesis of amides, which are widely found in natural products and pharmaceutical compounds.The high reactivity of the ruthenium complexes will be exploited in the conversion of nitro and nitrile containing compounds into amines. Since nitro and nitrile containing compounds are useful in C-C bond forming reactions, this provides powerful methodology for the synthesis of a wide range of amines.The principles of the borrowing hydrogen chemistry will be developed for the synthesis of heterocycles and complex alkaloids, and extended to the formation of compounds with the control of chirality