CVD Risk in Minority Populations w/ and w/o Type 2 Diabetes: Haitian and Black

描述(申请人提供)：2型糖尿病患者患冠心病(CHD)及其并发症的风险更大。本研究的目的是调查两个未被充分研究的少数民族人群，非裔美国人(AA)和海地人，他们患有和不患有2型糖尿病，以及发展为冠心病的危险因素。国家慢性病预防和健康促进中心的年龄调整数据显示，少数民族人口受到糖尿病的影响不成比例，2004年黑人男性和女性患糖尿病的比例最高。大多数已发表的研究要么单独研究了AAs，要么没有通过将不同种族和地理来源的族裔群体归类为一个单一群体来认识到不同种族和地理来源的民族和文化在糖尿病患病率/发病率、发病率和死亡率方面的差异。黑人的数据不能推广到其他种族，因为他们的传统、文化背景和影响健康和疾病的饮食习惯的差异。为了开发有效的治疗和预防方法，重要的是要有关于糖尿病状况和相关心血管疾病风险的基线数据。 我们假设，根据生化和饮食指数，患有2型糖尿病的AA和海地人患心血管疾病(CVD)的风险将比非糖尿病患者更大。基于糖尿病女性的死亡率高于男性，我们预计AA和海地患有2型糖尿病的女性比AA和海地男性有更多的心血管危险因素。拟议的研究是一项流行病学研究，受试者分组如下：糖尿病和非糖尿病AA和海地人，每组240名受试者(总计N=480)。进一步的分组将以性别为基础(N=每个族裔群体每个性别60人)。糖尿病受试者将通过从社区人群中随机选择非糖尿病受试者在年龄和性别上进行匹配。将对心血管疾病的生化、遗传和饮食指标的结果进行评估，以制定与糖尿病状况、性别和年龄有关的风险概况。将进行统计分析，以确定群体之间的显著差异(t检验)和该人群中心血管疾病的显著预测因素，使用多重回归分析和逻辑回归分析。这项研究的结果将解决2010年健康人在少数民族中糖尿病方面的至少两个目标。

DESCRIPTION (provided by applicant): Patients with type 2 diabetes have a greater risk of developing coronary heart disease (CHD) and its complications. The purpose of this research is to investigate two understudied minority populations, African American (AA) and Haitian, with and without type 2 diabetes and risk factors of developing CHD. The National Center for Chronic Disease Prevention and Health Promotion age-adjusted data shows that minority populations are disproportionately affected by diabetes, with black males and females having the highest percent of diabetes in 2004. Most published studies have either studied AAs alone or failed to acknowledge ethnic and cultural differences in diabetes prevalence/ incidence, morbidity and mortality among ethnic groups of varying races and geographic origin by lumping them into a single group. Data for blacks cannot be generalized to other ethnicities due to the differences in their heritage, cultural background, and food habits that influence health and disease. In order to develop effective treatment and prevention methodologies, it is important to have baseline data regarding diabetes status and associated risks for CVD. We hypothesize that cardiovascular disease (CVD) risks will be greater for AAs and Haitians with type 2 diabetes than non-diabetics based on biochemical and dietary indices. We expect AA and Haitian women with type 2 diabetes to have a greater number of CVD risk factors than AA and Haitian men based on greater mortality reported among diabetic women than men. The proposed study is an epidemiological study with subject groupings as follows: diabetic and non-diabetic AAs and Haitians with 240 subjects in each group (total N = 480). Further groupings will be based on gender (N = 60 per gender per ethnic group). Diabetic subjects will be matched for age and gender by randomly selecting the non-diabetic subjects from a community-based population group. Results of the biochemical, genetic and dietary indicators of CVD will be assessed to develop risk profiles in relation to diabetes status, gender and age. Statistical analysis will be performed to determine significant differences (t-test) between groups and the significant predictors of CVD in this population using multiple and logistical regression analysis. Results of this study will address at least two of the objectives of the Healthy People 2010 with regard to diabetes among minorities.