CVD Risk in Minority Populations w/ and w/o Type 2 Diabetes: Haitian and Black

描述（由申请人提供）：2型糖尿病患者发生冠心病（CHD）及其并发症的风险更高。本研究的目的是调查两个未被充分研究的少数人群，非裔美国人和海地人，有无2型糖尿病和发生冠心病的危险因素。国家慢性疾病预防和健康促进中心的年龄调整数据显示，少数民族人口受到糖尿病的影响不成比例，2004年黑人男性和女性患糖尿病的比例最高。大多数已发表的研究要么单独研究AAs，要么没有承认不同种族和地理来源的种族群体在糖尿病患病率/发病率、发病率和死亡率方面的种族和文化差异，而是将它们集中在一个群体中。黑人的数据不能推广到其他种族，因为他们的遗产、文化背景和饮食习惯的差异会影响健康和疾病。为了开发有效的治疗和预防方法，重要的是要有关于糖尿病状况和心血管疾病相关风险的基线数据。

DESCRIPTION (provided by applicant): Patients with type 2 diabetes have a greater risk of developing coronary heart disease (CHD) and its complications. The purpose of this research is to investigate two understudied minority populations, African American (AA) and Haitian, with and without type 2 diabetes and risk factors of developing CHD. The National Center for Chronic Disease Prevention and Health Promotion age-adjusted data shows that minority populations are disproportionately affected by diabetes, with black males and females having the highest percent of diabetes in 2004. Most published studies have either studied AAs alone or failed to acknowledge ethnic and cultural differences in diabetes prevalence/ incidence, morbidity and mortality among ethnic groups of varying races and geographic origin by lumping them into a single group. Data for blacks cannot be generalized to other ethnicities due to the differences in their heritage, cultural background, and food habits that influence health and disease. In order to develop effective treatment and prevention methodologies, it is important to have baseline data regarding diabetes status and associated risks for CVD. We hypothesize that cardiovascular disease (CVD) risks will be greater for AAs and Haitians with type 2 diabetes than non-diabetics based on biochemical and dietary indices. We expect AA and Haitian women with type 2 diabetes to have a greater number of CVD risk factors than AA and Haitian men based on greater mortality reported among diabetic women than men. The proposed study is an epidemiological study with subject groupings as follows: diabetic and non-diabetic AAs and Haitians with 240 subjects in each group (total N = 480). Further groupings will be based on gender (N = 60 per gender per ethnic group). Diabetic subjects will be matched for age and gender by randomly selecting the non-diabetic subjects from a community-based population group. Results of the biochemical, genetic and dietary indicators of CVD will be assessed to develop risk profiles in relation to diabetes status, gender and age. Statistical analysis will be performed to determine significant differences (t-test) between groups and the significant predictors of CVD in this population using multiple and logistical regression analysis. Results of this study will address at least two of the objectives of the Healthy People 2010 with regard to diabetes among minorities.