CVD Risk in Minority Populations w/ and w/o Type 2 Diabetes: Haitian and Black

描述（由申请人提供）：2型糖尿病患者发生冠心病及其并发症的风险更大。本研究的目的是调查两个未充分研究的少数民族人群，非洲裔美国人（AA）和海地人，有和没有2型糖尿病和冠心病的危险因素。国家慢性病预防和健康促进中心的年龄调整数据显示，少数民族人口不成比例地受到糖尿病的影响，2004年黑人男性和女性的糖尿病比例最高。大多数已发表的研究要么单独研究了AA，要么将不同种族和地理来源的种族群体归为一组，从而未能承认糖尿病患病率/发病率、发病率和死亡率的种族和文化差异。黑人的数据不能推广到其他种族，因为他们的遗产，文化背景和影响健康和疾病的饮食习惯的差异。为了开发有效的治疗和预防方法，重要的是要有关于糖尿病状态和CVD相关风险的基线数据。 我们假设，心血管疾病（CVD）的风险将是更大的AA和海地2型糖尿病患者比非糖尿病患者的基础上生化和饮食指标。我们预计AA和海地女性2型糖尿病患者比AA和海地男性有更多的心血管疾病危险因素，这是基于糖尿病女性的死亡率高于男性。拟定研究是一项流行病学研究，受试者分组如下：糖尿病和非糖尿病AA和海地人，每组240例受试者（总N = 480）。进一步分组将基于性别（N = 60/性别/种族）。通过从社区人群组中随机选择非糖尿病受试者，对糖尿病受试者进行年龄和性别匹配。心血管疾病的生化、遗传和饮食指标的结果将被评估，以建立与糖尿病状态、性别和年龄相关的风险特征。将进行统计分析，以确定组间的显著差异（t检验），并使用多元和逻辑回归分析确定该人群中CVD的显著预测因素。这项研究的结果将至少涉及《2010年健康人》关于少数民族糖尿病的两项目标。

DESCRIPTION (provided by applicant): Patients with type 2 diabetes have a greater risk of developing coronary heart disease (CHD) and its complications. The purpose of this research is to investigate two understudied minority populations, African American (AA) and Haitian, with and without type 2 diabetes and risk factors of developing CHD. The National Center for Chronic Disease Prevention and Health Promotion age-adjusted data shows that minority populations are disproportionately affected by diabetes, with black males and females having the highest percent of diabetes in 2004. Most published studies have either studied AAs alone or failed to acknowledge ethnic and cultural differences in diabetes prevalence/ incidence, morbidity and mortality among ethnic groups of varying races and geographic origin by lumping them into a single group. Data for blacks cannot be generalized to other ethnicities due to the differences in their heritage, cultural background, and food habits that influence health and disease. In order to develop effective treatment and prevention methodologies, it is important to have baseline data regarding diabetes status and associated risks for CVD. We hypothesize that cardiovascular disease (CVD) risks will be greater for AAs and Haitians with type 2 diabetes than non-diabetics based on biochemical and dietary indices. We expect AA and Haitian women with type 2 diabetes to have a greater number of CVD risk factors than AA and Haitian men based on greater mortality reported among diabetic women than men. The proposed study is an epidemiological study with subject groupings as follows: diabetic and non-diabetic AAs and Haitians with 240 subjects in each group (total N = 480). Further groupings will be based on gender (N = 60 per gender per ethnic group). Diabetic subjects will be matched for age and gender by randomly selecting the non-diabetic subjects from a community-based population group. Results of the biochemical, genetic and dietary indicators of CVD will be assessed to develop risk profiles in relation to diabetes status, gender and age. Statistical analysis will be performed to determine significant differences (t-test) between groups and the significant predictors of CVD in this population using multiple and logistical regression analysis. Results of this study will address at least two of the objectives of the Healthy People 2010 with regard to diabetes among minorities.