PET Insert for MAGNETOM Trio

MAGNETOM Trio 的 PET 插件

• 批准号: 7497239
• 负责人: CHESTER A MATHIS
• 金额: $ 200万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497239
• 关键词: Acute; Advisory Committees; Affect; Anatomy; Area; Atlases; Brain; Brain imaging; Brain region; Cerebrovascular Circulation; Classification; Compatible; Condition; Critical Care; Data; Data Set; Environment; Epilepsy; Functional Magnetic Resonance Imaging; Funding; Head and Neck Cancer; Head and Neck Neoplasms; Human; Hybrids; Image; Institution; Ionizing radiation; Magnetic Resonance; Magnetic Resonance Imaging; Multimodal Imaging; Neurology; Neurosciences; PET/CT scan; Pathology; Performance; Physical Medicine; Physiological; Physiology; Positron-Emission Tomography; Psychiatry; Public Health; Purpose; Radiation; Radiation Oncology; Radiology Specialty; Rehabilitation therapy; Request for Proposals; Research; Research Personnel; Research Project Grants; Resolution; Resource Sharing; Sensory Receptors; Signal Transduction; Site; Small Animal Imaging Systems; Spectrum Analysis; Stroke; System; TRIO gene; Technology; Therapeutic Agents; Tissues; Tube; Universities; Validation; attenuation; base; cognitive function; design; detector; human TRIO protein; human subject; instrument; instrumentation; magnetic field; neurosurgery; oncology; pre-clinical; response; treatment planning; tumor

DESCRIPTION (provided by applicant): This proposal requests funds for a newly available high resolution PET tomograph insert to produce a hybrid MR/PET system allowing true simultaneous acquisition of PET and MR brain imaging data in human subjects. The PET insert will be combined with an existing 3T Siemens TRIO MR system (for which it is specifically designed). The resulting hybrid MR/PET system will be available as a shared resource to researchers at the University of Pittsburgh and other local institutions. Departments within the University that that will benefit from the instrument include: Psychiatry, Radiology & Radiation Oncology, Physical Medicine & Rehabilitation, Neurology & Neurosurgery, Pathology, and Otolararyngology. The system will be sited in the University of Pittsburgh Magnetic Resonance Research Center and will be managed and directed by an Internal Advisory Committee composed of the co-investigators and major users identified in this proposal. The insert uses new PET detector technology, with magnetically insensitive avalanche photodiodes (APDs) in favor of photo-multiplier tubes (PMTs), and consists of a detector ring that fits inside the MR bore. The use of APDs for MR-compatible PET is established in pre-clinical systems for small animal imaging. The proposed insert performs better than present instrumentation for human brain PET imaging, and can operate within the high magnetic field environment without significantly affecting the performance of the MR system. The MR images may be used for attenuation correction of the PET data such that no ionizing radiation is associated with this purpose, as is not the case for PET or PET/CT imaging. The system will provide PET datasets that are intrinsically co-registered with anatomical and functional MR datasets (fMRI, DTI, spectroscopy) in both spatial and temporal domains. Areas where we expect the system to significantly enhance investigational research are: 1) Functional and physiologic validation paradigms (e.g. BOLD MR signal vs. [15O]H2O PET cerebral blood flow). 2) Characterization of the relationship between cognitive function (fMRI) and neuroreceptor occupancy by therapeutic agents and/or an acute pharmacologic challenge (PET). 3) Studies in critical care or ephemeral conditions (e.g. stroke, epilepsy, MS), for which the highly dynamic physiology demands simultaneous anatomical and functional assessments. 4) Precise anatomic delineation and simultaneous functional assessment of brain and head-and-neck tumors for radiation treatment planning, as well as longitudinal assessments of anatomic and functional tumor response. 5) More precise application of structural MR results with respect to atlas-based delineation of brain regions, tissue classification/segmentation, and volumetric assessments. The introduction of multimodality MR/PET systems is expected to have a broad impact on investigational neuroscience and radiation treatment planning and assessment of response in oncology. 11 Major User NIH-funded research projects at the University of Pittsburgh that will immediately benefit from this new multimodality technology are identified. PUBLIC HEALTH RELEVANCE:

描述（由申请人提供）：该提案要求为新的高分辨率PET断层扫描仪插入物提供资金，以生产混合MR/PET系统，从而能够真正同时采集人类受试者的PET和MR脑成像数据。PET衬垫将与现有的3 T Siemens TRIO MR系统（专门为此设计）结合使用。由此产生的混合MR/PET系统将作为共享资源提供给匹兹堡大学和其他当地机构的研究人员。大学内将受益于该仪器的部门包括：精神病学，放射学和放射肿瘤学，物理医学和康复，神经病学和神经外科，病理学和耳鼻喉科。该系统将设在匹兹堡大学磁共振研究中心，并由一个内部咨询委员会管理和指导，该委员会由本提案中确定的共同研究者和主要用户组成。该插件使用新的PET探测器技术，具有磁不敏感雪崩光电二极管（APD），有利于光电倍增管（PMT），并由一个适合MR孔内的探测器环组成。在小动物成像的临床前系统中确定了APD用于MR兼容PET。申报的插入物在人脑PET成像方面的性能优于现有仪器，并且可以在高磁场环境中运行，而不会显著影响MR系统的性能。MR图像可以用于PET数据的衰减校正，使得没有电离辐射与该目的相关联，这与PET或PET/CT成像的情况不同。该系统将提供PET数据集，这些数据集在空间和时间域中与解剖和功能MR数据集（fMRI、DTI、光谱学）内在地共配准。我们预计该系统将显著增强调查研究的领域是：1）功能和生理验证范例（例如BOLD MR信号与[15 O]H2O PET脑血流）。2)认知功能（fMRI）与治疗药物和/或急性药理学激发（PET）的神经受体占用率之间关系的表征。3)重症监护或短暂性疾病（如中风、癫痫、MS）的研究，高度动态的生理学需要同时进行解剖和功能评估。4)精确的脑和头颈部肿瘤的解剖描绘和同步功能评估，用于放射治疗计划，以及解剖和功能肿瘤反应的纵向评估。5)在基于图谱的脑区描绘、组织分类/分割和体积评估方面，更精确地应用结构MR结果。多模态MR/PET系统的引入预计将对研究神经科学和放射治疗计划以及肿瘤学反应评估产生广泛影响。匹兹堡大学的11个主要用户NIH资助的研究项目将立即受益于这种新的多模态技术。 公共卫生相关性：