Nicolet Continumm XL FTIR Microscope System

描述(由申请人提供)：NIH资助的四个研究项目可以大大受益于所要求的共享新的最先进仪器的可用性：Nicolet Continuum FTIR显微镜：1)NIH赠款AR-051446：“通过磁共振显微镜进行骨形成研究”首席研究员：金伯利·波特博士(武装部队病理研究所)。2)美国国立卫生研究院授予DE-13169：“无定形磷酸钙牙科材料”，首席研究员：Dr.Drago Skrtic(Paffenbarger研究中心)。3)美国国立卫生研究院授予DE-11789：“磷酸钙骨移植材料”，首席研究员：拉里·周博士(Paffenbarger Research Center)。4)美国国立卫生研究院授予DE-5129：“预防和修复材料的改进”，首席研究员：拉斐尔·鲍文博士(Paffenbarger研究中心)。目前的FTIR显微光谱分析系统：“与Nicolet Magna-IR 550 FTIR分光光度计接口的Nicplan IR显微镜”已于2005年12月31日被Thermo Electron Corporation淘汰，已过时。所要求的最先进的系统：“Nicolet Continuum FTIR显微镜与新的Nicolet 6700金多范围中红外/近红外光谱仪”和额外的配件，由Thermo Electron公司制造，将使我们能够在更短的采集时间内获得更高空间分辨率和更多化学细节的FTIR地图和图像，因为更高的红外强度和测绘阶段的新技术，以及覆盖更大光谱范围的特殊单元素检测器，这在测绘磷酸钙和各种牙齿组织、骨骼和牙科材料时非常重要。相关性：这一新的共享工具将以更少的时间提供更多的数据和更关键的细节，从而极大地受益于上述由NIH资助的四个研究项目。NIH资助的研究项目涵盖了广泛的高影响生物医学和牙科研究，包括以下主题：校准新的核磁共振成像技术，它可以非侵入性地评估骨骼组织在骨骼形成、骨折愈合和骨长入骨科植入物期间发生的变化，而不是目前基于X射线的技术，以跟踪暴露在电离辐射下的健康受试者的骨骼变化(Potter)；设计新的牙科复合材料和正畸水泥原型(Skrtic)；设计更好的骨移植材料，用于牙周缺陷修复、牙槽骨增强、脊柱融合以及颅面和矫形外科应用(Chow)；以及配制用于牙本质和牙釉质粘接的新型强力粘结剂(Bowen)。

DESCRIPTION (provided by applicant): Four NIH funded research projects could greatly benefit from the availability of the requested shared new state of the art instrument: Nicolet Continuum FTIR microscope: 1) NIH grant AR-051446: "Bone Formation Studies by Magnetic Resonance Microscopy" Principal Investigator: Dr. Kimberlee Potter (Armed Forces Institute of Pathology). 2) NIH grant DE-13169: "Amorphous Calcium Phosphate Dental Materials", Principal Investigator: Dr. Drago Skrtic (Paffenbarger Research Center). 3) NIH grant DE-11789: "Calcium Phosphate Bone Graft Materials", Principal Investigator: Dr. Larry Chow (Paffenbarger Research Center). 4) NIH grant DE-5129: "Improvement of Preventive and Restorative Materials", Principal Investigator: Dr. Rafael Bowen (Paffenbarger Research Center). The current FTIR microspectroscopy system: "NicPlan IR microscope interfaced with Nicolet Magna-IR 550 FTIR spectrophotometer" was retired by Thermo Electron Corporation on 12/31/05 and is out of date. The requested state-of-the-art system: "Nicolet Continuum FTIR microscope with a new Nicolet 6700 Gold Multi- Range Mid-IR/Near-IR spectrophotometer" and additional accessories manufactured by Thermo Electron Corporation will enable us to obtain FTIR maps and images with higher spatial resolution and more chemical details in shorter collection times due to the higher intensity of the IR and the new technology of the mapping stage and the special one element detector that covers larger spectral range which is very important when mapping calcium phosphates and various dental tissues, bone and dental materials. Relevance: This new shared instrument will benefit tremendously the four NIH-funded research projects mentioned above by providing more data with more crucial details and in much less time. The NIH-funded research projects cover a wide range of high impact biomedical and dental research including topics such as: calibrating the new NMR imaging technique that can non-invasively evaluate the changes that occur in skeletal tissues during skeletogenesis, fracture healing, and bone growth into orthopedic implants, in contrast to the current X-ray based techniques to follow the skeletal changes that expose healthy subjects to ionizing radiation (Potter); designing of new dental composites and formulation of a prototype orthodontic cement (Skrtic); designing of better bone graft materials for periodontal defect repair, ridge augmentation, spinal fusion, and craniofacial and orthopedic applications (Chow); and formulating new and strong adhesives for dentin and enamel bonding (Bowen).