Using CPL for Enantioselective Recognition of Amino Acids

本提案中描述的工作旨在作为一个起点，旨在证明 圆偏振发光(CPL)光谱将是一种有吸引力的补充和/或 作为手性分子的特定结构探针的当前技术的替代方法。首字母 这个项目的努力将是开发一种技术来确定简单的绝对立体化学 氨基酸等手性有机分子。这里的重点是设计实验，目的是 了解、改进和最大化支配手性的主要非共价相互作用 外消旋稀土(111)配合物与手性有机分子的鉴别。几个目标将 这项建议的主要内容是：(一)通过设计和 合成适当的配体，(Ii)在我们的复杂体系中加入手性将改善 对简单手性分子的选择性，(Iii)用于环状的所选转变的明智变化 极化激发将克服目前允许的磁场强度低的限制 选择偶极子用于CPL测量，但也将显著增强获得的结构信息 来自欧盟(11)感兴趣的系统，以及(Iv)各种非共价的重要性的调查 手性歧视相互作用。 这项工作的最终目标是能够将CPL光谱开发为生物学的重要工具 申请。

The work described in this proposal is intended to serve as a starting point aimed at demonstrating that circularly polarized luminescence (CPL) spectroscopy would be an attractive complementary and/or alternative method to current techniques used as specific structural probes of chiral molecules. The initial efforts in this project will be to develop a technique to determine the absolute stereochemistry of simple chiral organic molecules such as amino acids. The emphasis here is the design of experiments aimed at understanding, improving, and maximizing the major non-covalent interactions governing the chiral discrimination between racemic lanthanide(lll) complexes and chiral organic molecules. Several aims will form the bulk of this proposal: (i) the ability to identify "ideal" racemic lanthanide complexes by designing and synthesizing appropriate ligands, (ii) the addition of chirality into our complex systems will improve the selectivity toward simple chiral molecules, (iii) a judicious change in the selected transition used for circular polarization excitation would overcome the limitation of the low intensity of the currently allowed-magnetic dipole chosen for CPL measurement, but will also considerably enhance the structural information gained from the Eu(lll) systems of interest, and (iv) the investigation of the importance of the various non-covalent chiral discriminatory interactions. The ultimate goal of this work is to be able to develop CPL spectroscopy as an important tool for biological applications.