Follow On: Novel Libraries of Building Blocks for Combinatorial Drug Discovery

后续：用于组合药物发现的新型构建模块库

• 批准号: EP/E501184/1
• 负责人: Mike Shipman
• 金额: $ 8.16万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE501184%2F1
• 关键词: Follow; Novel; Libraries; Building; Blocks

Hydantoins and their derivatives have many pharmaceutical and agrochemical applications. We have invented a simple, one-step method to an important subclass of these compounds, namely 5,5-disubstituted hydantoins. Chemical libraries of this type are rather inaccessible and appear underrepresented in commercial compound collections. Hence, there is scope to produce and market them to these industries. To develop this business opportunity, we must first establish if highthroughput techniques can be applied so that many saleable compounds can be made quickly and cheaply. Herein, we will explore both parallel synthesis methods and microwave acceleration. This project will also investigate the conversion of hydantoins into other important building blocks such as a,a-disubstituted a-amino acids. We aim to establish a company to exploit this technology and the work funded herein will produce the vital results needed to secure seedcorn funding and establish a sustainable business.

海因及其衍生物在医药和农用化学品方面有许多应用。我们发明了一种简单的一步法来合成这些化合物的一个重要亚类，即5，5-二取代海因。这种类型的化学库相当难以访问，在商业化合物收藏中似乎没有得到充分的代表。因此，有机会生产并向这些行业销售它们。为了开发这一商机，我们必须首先确定是否可以应用高通量技术，以便能够快速和廉价地制造许多畅销化合物。在这里，我们将探索并行合成方法和微波加速。该项目还将研究将海因转化为其他重要构件的情况，如a，a-二取代a-氨基酸。我们的目标是建立一家利用这项技术的公司，这里资助的工作将产生确保种子玉米资金和建立可持续业务所需的关键结果。