Follow On: Novel Libraries of Building Blocks for Combinatorial Drug Discovery

海因酮及其衍生物有许多医药和农用化学品的应用。我们已经发明了一种简单的一步法来获得这些化合物的一个重要子类，即5,5-二取代氢酰脲。这种类型的化学文库是相当难以接近的，并且在商业化合物收藏中显得代表性不足。因此，有生产和销售这些行业的空间。为了开发这一商机，我们必须首先确定是否可以应用高通量技术，以便快速廉价地制造出许多可销售的化合物。在此，我们将探索并行合成方法和微波加速。该项目还将研究氢酰脲转化为其他重要的组成部分，如a，a-二取代a-氨基酸。我们的目标是建立一家公司来开发这项技术，这里所资助的工作将产生重要的结果，以确保种子玉米资金和建立可持续的业务。

Hydantoins and their derivatives have many pharmaceutical and agrochemical applications. We have invented a simple, one-step method to an important subclass of these compounds, namely 5,5-disubstituted hydantoins. Chemical libraries of this type are rather inaccessible and appear underrepresented in commercial compound collections. Hence, there is scope to produce and market them to these industries. To develop this business opportunity, we must first establish if highthroughput techniques can be applied so that many saleable compounds can be made quickly and cheaply. Herein, we will explore both parallel synthesis methods and microwave acceleration. This project will also investigate the conversion of hydantoins into other important building blocks such as a,a-disubstituted a-amino acids. We aim to establish a company to exploit this technology and the work funded herein will produce the vital results needed to secure seedcorn funding and establish a sustainable business.