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Core Capability for Chemistry Research at the University of Warwick

华威大学化学研究核心能力

基本信息

批准号：
EP/L027100/1
负责人：
Mike Shipman
金额：
$ 126.66万
依托单位：
University of Warwick
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FL027100%2F1
关键词：
Core Capability Chemistry Research University

项目摘要

The main objective of this proposal is to enhance the research capabilities of the Department of Chemistry at the University of Warwick, through the acquisition of new equipment. We will add enhanced capabilities in matrix assisted laser desorption ionisation (MALDI) mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. These will have major beneficial impacts on >60% of staff and researchers in the Department through significant increases in both capacity (i.e. more samples can be run) and capability (i.e. better data through improved resolution). This equipment will enhance a wide range of research activities in EPSRC priority areas as detailed below:(i) Chemical Biology, where the proposed instruments will facilitate many programmes including genomics-driven natural product discovery and various medicinal chemistry programmes including the development of metal based pro-drugs. It will also underpin interests in Synthetic Biology. (ii) Synthesis and Catalysis - work in this EPSRC priority area includes work on transition metal catalysis, organocatalysis and biocatalysis. A variety of other synthetic chemistry programmes will be enhanced including those relevant to the EPSRC grand challenge, Dial-a-Molecule. (iii) Polymer Chemistry - many varied programmes will benefit including those focused on protein conjugation to polymers, glycopolymers, biomaterials, drug delivery and nanoreactors.(iv) Analytical Science - The increased sensitivity will enhance many projects including biophysical investigations of metalloproteins and membrane proteins. Importantly, the new capabilities will also help us further strengthen our engagement and collaboration with industry and relevant business sectors.

该提案的主要目的是通过购置新设备，提高沃里克大学化学系的研究能力。我们将在基质辅助激光解吸电离（MALDI）质谱和核磁共振（NMR）光谱方面增加增强功能。这将通过显著提高能力（即可以运行更多样本）和能力（即通过提高分辨率获得更好的数据），对该部60%以上的工作人员和研究人员产生重大有益影响。这些设备将加强EPSRC优先领域的广泛研究活动，详情如下：㈠化学生物学，拟议的仪器将促进许多方案，包括基因组学驱动的天然产品发现和各种药物化学方案，包括开发金属前药。它还将巩固对合成生物学的兴趣。(ii)合成和催化-EPSRC优先领域的工作包括过渡金属催化、有机催化和生物催化。各种其他合成化学方案将得到加强，包括那些相关的EPSRC大挑战，拨号一个分子。(iii)高分子化学-许多不同的计划将受益，包括那些专注于蛋白质共轭聚合物，糖共聚物，生物材料，药物输送和纳米反应器。(iv)分析科学-增加的灵敏度将增强许多项目，包括金属蛋白和膜蛋白的生物物理研究。重要的是，新功能还将帮助我们进一步加强与行业和相关业务部门的接触和合作。