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Support for Enhancement Excellence in Research at UPR RP

支持 UPR RP 提高卓越研究水平

基本信息

批准号：
7663453
负责人：
RAFAEL ARCE
金额：
$ 44.7万
依托单位：
UNIVERSITY OF PUERTO RICO RIO PIEDRAS
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7663453
关键词：
Achievement Affect Antibiotics Applications Grants Aspergillosis Award Behavior Biological Factors Biological Phenomena Biology Biomedical Research Chemicals Chemistry Chlorine Collaborations DNA Development Diagnosis Disease Drug Addiction Ensure Environment Escherichia coli Event Extramural Activities Faculty Fatty Acids Funding G-Quartets Genes Genetic Models Genetic Recombination Goals Grant Growth Guanosine Health Human Human Resources Individual Infection Institution International Journals Knowledge Laboratories Learning Lipids Location Magnetic Resonance Imaging Mathematics Measurable Measures Mediating Membrane Microdomains Mentors Methodology Minority Molecular Molecular Conformation Nanoarray Analytical Device Numbers Pathway interactions Peer Review Pharmaceutical Preparations Piedra Pilot Projects Prodrugs Productivity Proteins Publications Puerto Rico Qualifying Rate Reagent Research Research Infrastructure Research Personnel Research Project Grants Research Training Role Scientist Score Sea Secure Signal Transduction Soil Structure Students Time Trans-Activators Transducers Universities Urine analog cancer therapy career catalyst classical conditioning conformational conversion drug synthesis improved mRNA Decay mathematical model memory process microorganism nanoscale novel organ regeneration pollutant programs receptor recombinational repair relating to nervous system simulation skills transmission process tuberculosis treatment vector

项目摘要

This Competitive Renewal Application from the UPR-RP MBRS SCORE Program aims for continued growth in the quality and amount of biomedical research at the University of Puerto Rico-Rio Piedras. Recognising that raising the level of achievement entails greater productivity and more emphasis on competitive research funding, the following goals have been established for this funding cycle: 1) To enhance the biomedical research competitiveness of the faculty (knowledge, skills and capabilities) by their participation in scientifically meritorious research projects and by their involvement in associated activities. 2) to provide more opportunity for qualified graduate, undergraduate and postdoctoral students to participate in biomedical research; and 3) To strengthen the institutional commitment of UPR-Rio Piedras to biomedical research. These goals will be achieved by increasing the number of competitive grant applications at the rate of one per year per investigator, increasing the number of peer reviewed publications per year per investigator from the current average of 3.8 to 4.4, increasing the number of presentations per laboratory per year from the current average of 8 to 10, and augmenting the number of investigators engaged in biomedical research at the campus. This increased focus on research productivity is expected to result in an increase in the number of qualified and productive graduate and undergraduate students involved in biomedical research. This renewal contains 16 regular and 5 pilot projects from 7 investigators from the Biology Department, 12 from Chemistry and 2 from Mathematics. These projects aim to conduct competitive biomedical research on such topics as the role of DNA recombination and repair mechanism in learning and memory processes, the location of pudnergic receptors and transducers within membrane microdomains on signalling events, the molecular aspects of organ regenerations, the functional role of lipid protein interactions in the conformational transitions of the nicotinic acetyl chlorine receptor, protein inactivation and aggregation during encapsulation and release, the physical factors that affect conformational stability of proteins, the role of mGluRs in drug addiction and which specific neural connections mediate drug-induced associative learning and additive behavior, the trans-acting factors in nonsense-mediated mRNA decay pathway related to HRP1 trans-acting factor, the mechanism of aspergillosis in human and sea fan infections, the role of E. Coli as a possible vector of gene transmission and the possibility of soil environments serving as a reservoir of pathogenic microorganisms, the photochemical transformation of mutagenic pollutants; the synthesis or development of novel guanosine analogues to create stable G-quadruplexes for the treatment of cancer, selective asymmetric reagents and catalysts for chiral drug synthesis, an enantioselective methodology for the synthesis of polypropionate antibiotics, new MRI contrast enhancing agents of DNA nanoarray chips for disease diagnosis; the discovery of novel fatty acids that could be used as the lipid component of a prodrug, natural products from octocorals for the treatment of tuberculosis, the development and use of theoretical chemical and mathematical models for the urine concentrating mechanism, simulation of the stable conformation of nanometer sized DNA, and models of genetic networks including error correction. These investigators will be supported by an administrative structure and technical personnel funded by this program.

UPR-RP MBRS SCORE 计划的竞争性续订申请旨在持续提高质量和波多黎各大学里约彼德拉斯分校的生物医学研究量。认识到提高成就水平需要更高的生产力和更加重视竞争性研究经费，为此制定了以下目标资助周期： 1）通过以下方式增强教师的生物医学研究竞争力（知识、技能和能力）他们参与具有科学价值的研究项目以及相关活动。 2）到为合格的研究生、本科生和博士后提供更多参与生物医学的机会研究; 3) 加强 UPR-Rio Piedras 对生物医学研究的机构承诺。这些目标将可以通过以每位研究者每年申请一项的速度增加竞争性资助申请的数量来实现，每个研究者每年发表的同行评审出版物数量从目前的平均 3.8 篇增加到 4.4 篇，增加了每个实验室每年的报告从目前的平均 8 次增加到 10 次，并增加参与研究的研究人员数量校园内的生物医学研究。对研究生产力的日益关注预计将导致参与生物医学研究的合格且富有成效的研究生和本科生的数量。本次更新包含 16 个常规项目和 5 个试点项目，由来自生物系的 7 位研究人员、化学系的 12 位研究人员和 2 位研究人员共同完成。来自数学。这些项目旨在针对 DNA 重组的作用等主题开展竞争性生物医学研究学习和记忆过程中的修复机制、膜内pudnergic受体和传感器的位置微结构域对信号事件的影响、器官再生的分子方面、脂质蛋白相互作用的功能作用烟碱乙酰氯受体的构象转变、封装过程中的蛋白质失活和聚集释放、影响蛋白质构象稳定性的物理因素、mGluRs 在药物成瘾中的作用以及具体的神经连接介导药物诱导的联想学习和加性行为，无意义介导的反式作用因子与HRP1反式作用因子相关的mRNA衰减途径，曲霉病在人类和海扇感染中的机制，作用大肠杆菌作为基因传播的可能载体以及土壤环境作为病原体储存库的可能性微生物、致突变污染物的光化学转化；新型鸟苷的合成或开发用于创建用于治疗癌症的稳定 G-四链体的类似物、用于手性药物的选择性不对称试剂和催化剂合成，一种合成聚丙酸酯抗生素的对映选择性方法，新型 MRI 对比增强剂用于疾病诊断的DNA纳米阵列芯片；发现可用作脂质成分的新型脂肪酸前药、八珊瑚天然产物用于治疗结核病、理论化学和药物的开发和使用尿液浓缩机制的数学模型，纳米级DNA稳定构象的模拟，以及遗传网络模型，包括纠错。这些调查人员将得到行政结构和由该计划资助的技术人员。

项目成果

期刊论文数量（155）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Isolation and structural elucidation of euryjanicins B-D, proline-containing cycloheptapeptides from the Caribbean marine sponge Prosuberites laughlini.

DOI：
10.1021/np9004135
发表时间：
2009-09
期刊：
Journal of natural products
影响因子：
5.1
作者：
Vera B;Vicente J;Rodríguez AD
通讯作者：
Rodríguez AD

Arginine vasopressin gene expression changes within the nucleus accumbens during environment elicited cocaine-conditioned response in rats.

DOI：
10.1016/j.neuropharm.2009.06.040
发表时间：
2010-01
期刊：
Neuropharmacology
影响因子：
4.7
作者：
Rodríguez-Borrero E;Rivera-Escalera F;Candelas F;Montalvo J;Muñoz-Miranda WJ;Walker JR;Maldonado-Vlaar CS
通讯作者：
Maldonado-Vlaar CS

Aberrarone: a gorgonian-derived diterpene from Pseudopterogorgia elisabethae.