Support for Enhancement Excellence in Research at UPR RP

来自UPR-RP MBRS SCORE计划的这一竞争性续约申请旨在持续提高质量， 波多黎各大学里奥皮德拉斯分校的大量生物医学研究。认识到提高成就水平 需要更高的生产力和更多的竞争性研究经费的重视，以下目标已经建立了这一点 资助周期：1）通过以下方式提高学院的生物医学研究竞争力（知识，技能和能力） 他们参与有科学价值的研究项目，并参与相关活动。2)到 为合格的研究生、本科生和博士后学生提供更多机会，参与生物医学 加强普遍定期审议-里约彼德拉斯对生物医学研究的机构承诺。这些目标将 通过增加竞争性补助金申请的数量，以每名研究人员每年一份的速度， 每名研究者每年的同行评审出版物数量从目前的平均3.8份增加到4.4份， 每个实验室每年的平均报告数从目前的8个增加到10个，并增加参与研究的研究人员人数。 生物医学研究这种对研究生产力的日益重视预计将导致 参与生物医学研究的合格和富有成效的研究生和本科生人数。 这次更新包括16个常规项目和5个试点项目，来自生物系的7名研究人员，化学系的12名研究人员和 从数学。这些项目旨在就DNA重组的作用等主题进行竞争性生物医学研究 学习记忆过程中的神经递质和修复机制、pudnergic receptor和transducers在膜内的定位 微结构域对信号事件，器官再生的分子方面，脂质蛋白相互作用的功能作用， 烟碱乙酰氯受体的构象转变、蛋白质失活和包封过程中的聚集， 释放，影响蛋白质构象稳定性的物理因素，mGluRs在药物成瘾中的作用，以及mGluRs的特异性 神经连接介导药物诱导的联想学习和加法行为，无义介导的反式作用因子 mRNA衰变途径相关的HRP 1反式作用因子，曲霉菌病的机制，在人类和海扇感染中的作用 大肠大肠杆菌作为一种可能的基因传播载体和土壤环境作为病原体储存库的可能性 微生物，诱变污染物的光化学转化;新型鸟苷的合成或开发 制备用于治疗癌症的稳定的G-四链体的类似物，用于手性药物的选择性不对称试剂和催化剂 合成，用于合成聚丙酸酯抗生素的对映选择性方法， 用于疾病诊断的DNA纳米阵列芯片;新脂肪酸的发现，可用作脂肪酸的脂质成分。 前药，用于治疗结核病的珊瑚虫天然产物，理论化学品的开发和使用， 尿液浓缩机理的数学模型，纳米级DNA稳定构象的模拟， 包括误差校正的遗传网络模型。这些调查员将得到一个行政结构的支助， 由该计划资助的技术人员。

This Competitive Renewal Application from the UPR-RP MBRS SCORE Program aims for continued growth in the quality and amount of biomedical research at the University of Puerto Rico-Rio Piedras. Recognising that raising the level of achievement entails greater productivity and more emphasis on competitive research funding, the following goals have been established for this funding cycle: 1) To enhance the biomedical research competitiveness of the faculty (knowledge, skills and capabilities) by their participation in scientifically meritorious research projects and by their involvement in associated activities. 2) to provide more opportunity for qualified graduate, undergraduate and postdoctoral students to participate in biomedical research; and 3) To strengthen the institutional commitment of UPR-Rio Piedras to biomedical research. These goals will be achieved by increasing the number of competitive grant applications at the rate of one per year per investigator, increasing the number of peer reviewed publications per year per investigator from the current average of 3.8 to 4.4, increasing the number of presentations per laboratory per year from the current average of 8 to 10, and augmenting the number of investigators engaged in biomedical research at the campus. This increased focus on research productivity is expected to result in an increase in the number of qualified and productive graduate and undergraduate students involved in biomedical research. This renewal contains 16 regular and 5 pilot projects from 7 investigators from the Biology Department, 12 from Chemistry and 2 from Mathematics. These projects aim to conduct competitive biomedical research on such topics as the role of DNA recombination and repair mechanism in learning and memory processes, the location of pudnergic receptors and transducers within membrane microdomains on signalling events, the molecular aspects of organ regenerations, the functional role of lipid protein interactions in the conformational transitions of the nicotinic acetyl chlorine receptor, protein inactivation and aggregation during encapsulation and release, the physical factors that affect conformational stability of proteins, the role of mGluRs in drug addiction and which specific neural connections mediate drug-induced associative learning and additive behavior, the trans-acting factors in nonsense-mediated mRNA decay pathway related to HRP1 trans-acting factor, the mechanism of aspergillosis in human and sea fan infections, the role of E. Coli as a possible vector of gene transmission and the possibility of soil environments serving as a reservoir of pathogenic microorganisms, the photochemical transformation of mutagenic pollutants; the synthesis or development of novel guanosine analogues to create stable G-quadruplexes for the treatment of cancer, selective asymmetric reagents and catalysts for chiral drug synthesis, an enantioselective methodology for the synthesis of polypropionate antibiotics, new MRI contrast enhancing agents of DNA nanoarray chips for disease diagnosis; the discovery of novel fatty acids that could be used as the lipid component of a prodrug, natural products from octocorals for the treatment of tuberculosis, the development and use of theoretical chemical and mathematical models for the urine concentrating mechanism, simulation of the stable conformation of nanometer sized DNA, and models of genetic networks including error correction. These investigators will be supported by an administrative structure and technical personnel funded by this program.