Behavioral Therapy Development Program for Mindfulness Based Smoking Cessation

描述（由申请人提供）：目的：本申请申请NIH-NIDA K23指导临床研究人员培训补助金，用于James Davis博士进行行为治疗开发研究。在为期5年的资助期内，这笔资金将用于帮助戴维斯博士成为成瘾医学领域的一名医生兼研究员。背景：当代吸烟者表现出与高水平尼古丁依赖和情感性合并症相关的治疗抵抗。正念训练已被证明可以增强注意力控制，减少负面影响和压力，这些影响与这些治疗阻力的来源特别相关。研究：拟议的研究旨在进一步开发和测试新的吸烟干预正念戒烟（MBSC）在NIDA行为治疗发展计划的第一阶段和第二阶段。一项对吸烟者进行正念训练的可行性研究现已完成，并显示出有希望的结果。在资助期的第一年及第二年，透过干预发展研究、教师培训课程，以及制作理学士课程和培训手册，完成第一阶段的干预发展。通过随机对照试验，分配3、4年级进行MBSC治疗效果测试。第五年负责发表研究结果及申请R01补助金，以作研究机制及传播之用。意义：由于目前美国吸烟者对现有治疗方法的抵抗力越来越强，因此需要新的技术来专门解决治疗成功的障碍，如负面影响和高度尼古丁依赖。正念训练是一种新颖的技术，似乎有望克服这些治疗障碍。资格：戴维斯博士在威斯康星大学烟草研究与干预中心的蒂莫西·贝克博士的指导下进行成瘾研究。2006年10月，在完成一项研究奖学金后，戴维斯博士将被任命为华盛顿大学医学系的教员。建议培训：这个为期5年的项目旨在培养戴维斯博士进行高水平独立成瘾研究所需的知识和技能。该计划将指导研究与课程作业、道德培训和全国会议结合起来。这笔拨款将为戴维斯博士提供资金，使他成为一名独立的成瘾研究人员。

DESCRIPTION (provided by applicant): Goal: This application requests an NIH-NIDA K23 mentored clinical researcher training grant for Dr. James Davis to conduct behavioral therapies development research. During the 5-year term of the grant, funding will be used to prepare Dr. Davis for a leadership role as a physician-researcher in the field of addiction medicine. Background: The contemporary population of smokers demonstrates treatment resistance related to high level nicotine dependence and affective comorbidities. Mindfulness training has been shown to increase attentional control and decrease negative affect and stress, effects that are particularly relevant to these sources of treatment resistance. Research: The proposed research is designed to further develop and test the new smoking intervention Mindfulness Based Smoking Cessation (MBSC) within stage-1 and stage-2 of the NIDA Behavioral Therapies Development Program. A feasibility study on mindfulness training in smokers is now complete and demonstrates promising results. Years 1 and 2 of the grant-funded period are allocated to stage-1 completion of intervention development through an intervention development study, a teacher training course, and through production of the MBSC course and training manuals. Year 3 and 4 are allocated for MBSC treatment efficacy testing through a randomized controlled trial. Year 5 is allocated to publication of results and to application for an R01 grant for research on mechanism and dissemination. Significance: Because the current US population of smokers has grown more resistant to available therapies, new techniques are needed that specifically address obstacles to treatment success such as negative affect and high nicotine dependence. Mindfulness training is a novel technique that appears to be promising in overcoming these treatment obstacles. Qualifications: Dr. Davis conducts addiction research under the mentorship of Dr. Timothy Baker at University of Wisconsin (UW) Center for Tobacco Research and Intervention. In October 2006, on completion of a research fellowship, Dr. Davis will be given a faculty appointment in the UW Department of Medicine. Proposed Training: This 5-year program is designed to develop knowledge and skills necessary for Dr. Davis to conduct high-level independent addiction research. The program incorporates mentored research with course work, ethics training, and national conferences. This grant will provide funding for Dr. Davis to develop a career as an independent addiction researcher.