Behavioral Therapy Development Program for Mindfulness Based Smoking Cessation

描述（由申请人提供）：目标：本申请要求为James Davis博士提供NIH-NIDA K23指导的临床研究人员培训补助金，以进行行为疗法开发研究。在赠款的5年期限内，资金将用于准备戴维斯博士作为成瘾医学领域的医生研究员的领导作用。背景资料：当代吸烟人群表现出与高水平尼古丁依赖和情感合并症相关的治疗抵抗。正念训练已被证明可以增加注意力控制，减少负面影响和压力，这些影响与治疗阻力的来源特别相关。研究：拟议的研究旨在进一步开发和测试NIDA行为疗法开发计划第1阶段和第2阶段内的新吸烟干预正念戒烟（MBSC）。一项关于吸烟者正念训练的可行性研究现已完成，并取得了可喜的成果。赠款资助期的第1年和第2年分配给通过干预发展研究、教师培训课程以及通过制作MBSC课程和培训手册完成干预发展的第1阶段。第3年和第4年通过随机对照试验分配用于MBSC治疗功效测试。第五年分配用于发表成果和申请R 01赠款，用于机制和传播研究。重要性：由于目前美国吸烟者对现有疗法的耐药性越来越强，因此需要新技术来专门解决治疗成功的障碍，如负面影响和高度尼古丁依赖。正念训练是一种新技术，似乎有希望克服这些治疗障碍。资质要求：戴维斯博士在威斯康星州大学烟草研究和干预中心的蒂莫西·贝克博士的指导下进行成瘾研究。2006年10月，在完成研究奖学金后，戴维斯博士将被任命为华盛顿大学医学系的教员。拟议培训：这个为期5年的计划旨在培养戴维斯博士进行高水平独立成瘾研究所需的知识和技能。该计划将指导研究与课程工作，道德培训和国家会议相结合。这笔赠款将为戴维斯博士提供资金，以发展作为独立成瘾研究人员的职业生涯。

DESCRIPTION (provided by applicant): Goal: This application requests an NIH-NIDA K23 mentored clinical researcher training grant for Dr. James Davis to conduct behavioral therapies development research. During the 5-year term of the grant, funding will be used to prepare Dr. Davis for a leadership role as a physician-researcher in the field of addiction medicine. Background: The contemporary population of smokers demonstrates treatment resistance related to high level nicotine dependence and affective comorbidities. Mindfulness training has been shown to increase attentional control and decrease negative affect and stress, effects that are particularly relevant to these sources of treatment resistance. Research: The proposed research is designed to further develop and test the new smoking intervention Mindfulness Based Smoking Cessation (MBSC) within stage-1 and stage-2 of the NIDA Behavioral Therapies Development Program. A feasibility study on mindfulness training in smokers is now complete and demonstrates promising results. Years 1 and 2 of the grant-funded period are allocated to stage-1 completion of intervention development through an intervention development study, a teacher training course, and through production of the MBSC course and training manuals. Year 3 and 4 are allocated for MBSC treatment efficacy testing through a randomized controlled trial. Year 5 is allocated to publication of results and to application for an R01 grant for research on mechanism and dissemination. Significance: Because the current US population of smokers has grown more resistant to available therapies, new techniques are needed that specifically address obstacles to treatment success such as negative affect and high nicotine dependence. Mindfulness training is a novel technique that appears to be promising in overcoming these treatment obstacles. Qualifications: Dr. Davis conducts addiction research under the mentorship of Dr. Timothy Baker at University of Wisconsin (UW) Center for Tobacco Research and Intervention. In October 2006, on completion of a research fellowship, Dr. Davis will be given a faculty appointment in the UW Department of Medicine. Proposed Training: This 5-year program is designed to develop knowledge and skills necessary for Dr. Davis to conduct high-level independent addiction research. The program incorporates mentored research with course work, ethics training, and national conferences. This grant will provide funding for Dr. Davis to develop a career as an independent addiction researcher.