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Enabling and Accelerating Metallocatalysis with Hydrogen Bonding

利用氢键实现并加速金属催化

基本信息

批准号：
EP/F000316/1
负责人：
Jianliang Xiao
金额：
$ 42.82万
依托单位：
University of Liverpool
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FF000316%2F1
关键词：
Enabling Accelerating Metallocatalysis Hydrogen Bonding

项目摘要

There are numerous important catalytic reactions that require the dissociation/displacement of a hydrogen bonding anion, e.g. halide and acetate anions, or a functional group, such as amines or carbonyls, from the catalytic centre. In many such reactions, the dissociation/displacement process impacts on the reaction rates and selectivities. Indeed, the presence of such a functionality coordinated to the catalyst can inhibit the catalysis entirely. We have recently discovered that the addition of simple, readily accessible hydrogen bond donors (HBD) can dramatically accelerate palladium-catalysed reactions such as the internal arylation of olefins by aryl bromides. The reaction rates we observed equal or exceed all previous catalytic systems for these reactions. We believe that the HBD functions by complexing the halide anion, aiding its removal from the metal coordination sphere without the need for, e.g., stoichiometric, toxic thallium salts as additives. It has recently been stated that The capacity to control anion-cation interactions is key to optimizing yield, chemoselectivity, regioselectivity, and stereoselectivity of chemical processes .... (Chem. Rev. 2005, 105, 2039). In this project, we wish to demonstrate that we can use hydrogen bonding to do this. In particular we will show that we can apply HBDs in order to: (i) accelerate, and direct, metallocatalysis; (ii) enable cascade metallo-organo catalytic reactions; and thus (iii) show that HBDs afford a new means of controlling catalytic activity and selectivity, and should always be considered for reactions in which hydrogen bonding anions/functionalities are involved. The capability to integrate homogeneous catalysis with organocatalysis to enable cascade metallo-organo catalysis would open up an exciting new area of catalysis, metallo-organo catalysis, given the promise being demonstrated by the emerging organocatalysis.

有许多重要的催化反应需要从催化中心解离/置换氢键合阴离子，例如卤化物和乙酸根阴离子，或官能团，例如胺或羰基。在许多这样的反应中，解离/置换过程影响反应速率和选择性。事实上，与催化剂配位的这种官能度的存在可以完全抑制催化作用。我们最近发现，添加简单，容易获得的氢键供体（HBD）可以显着加速钯催化的反应，如通过芳基溴的烯烃的内部芳基化。我们观察到的反应速率等于或超过了所有以前的催化系统，这些反应。我们认为HBD通过络合卤素阴离子起作用，帮助其从金属配位球中除去，而不需要例如，化学计量的有毒铊盐作为添加剂。最近有人指出，控制阴离子-阳离子相互作用的能力是优化化学过程的产率、化学选择性、区域选择性和立体选择性的关键。（Chem.Rev.2005，105，2039）。在这个项目中，我们希望证明我们可以使用氢键来做到这一点。特别是，我们将表明，我们可以应用HBDs，以便：（i）加速，并直接，催化;（ii）使级联金属有机催化反应;因此（iii）表明HBDs提供了一种新的手段控制催化活性和选择性，并应始终考虑在反应中，氢键阴离子/功能参与。将均相催化与有机催化相结合以实现级联金属-有机催化的能力将开辟一个令人兴奋的催化新领域，即金属-有机催化，因为新兴的有机催化所展示的前景。