Interhemispheric transfer of grasp control after stroke

偏瘫是中风后最常见的运动障碍，经常导致持久手。 功能障碍。长期目标是了解手部运动恢复的潜在机制。 中风后的功能，为临床实践中使用的康复方案提供科学依据。这个 具体的假设是，非受累的手可以帮助受累的手恢复。我们驻扎在 这一假说是关于观察到事先用不涉及的手握住可以改善预期的 部分受试者卒中后用受累手对物体重量的握力计划。基于这些 观察，这项建议的重点是调查信息传递的类型和性质 大脑半球，通过事先用不涉及的手操纵，以改进计划和执行 卒中后偏瘫患者与年龄匹配对照患者患手握力的研究这个 具体目标是：(1)调查来自肌肉传感器或触觉的与体重相关的信息 来自指尖的信息中介预期控制转移到手中的物体重量；(2) 检查与体重相关的信息是否需要在双手之间转移预期控制- 特定肌肉活动；以及(3)确定之前用非受累的手进行的操作 提高受累手握力的时间和空间神经肌肉控制能力。心理物理学 使用GRIP仪器的方法将用来检查规划所需的信息类型 掌握，并将定量肌电图仪用于调查非受累者的贡献 改善受累手握力的神经肌肉控制。该项目是作为 职业发展计划，以获得系统神经科学、运动控制和运动方面的培训 生物力学，同时掌握心理物理和肌电技术。PI是一种 康复医学系讲师，致力于支持 这块地。西奈山医学院和师范学院提供了丰富的环境，使 PI成为研究中风后康复机制的独立调查者，并 将运动控制研究转化为自愿运动康复的治疗方案 脑损伤后的功能。

Hemiparesis is the most commonmotor impairment after stroke that frequently results in persistent hand dysfunction. The long-term goal is to understand the mechanisms underlying the recovery of hand motor function after stroke to provide a scientific rationale for rehabilitation protocols used in clinical practice. The specific hypothesis is that the non-involved hand can assist in the recoveryof the involved hand. We base this hypothesis on the observation that prior grasping with the non-involved hand improved anticipatory planning of grasp to object weight with the involved hand in some subjects after stroke. Based on these observations, the focus of this proposal is to investigate the type and nature of information relayedacross the hemispheres, by prior manipulation with the non-involved hand, to improve planning and execution of grasp with the involved hand in patients with post-stroke hemiparesis and age-matched controls. The specific aims are to: (1) Investigate whether weight-related information from muscle sensors or tactile information from the fingertips mediates the transfer of anticipatory control to object weight across hands; (2) Examine whether weight-related information for transfer of anticipatory control across hands requires task- specific muscular activity; and (3) Determine whether prior manipulation with the non-involved hand improves the temporal and spatial neuromuscular control of grasping with the involved hand. Psychophysical methods using a grip instrument will be used to examine the type of information necessary for planning of grasp, and quantitative electromyography will be used to investigate the contribution of the non-involved hand in improving neuromuscular control of grasp in the involved hand. This project is proposed as part of a career development plan to obtain training in systemsneuroscience, motor control, andmovement biomechanics, while acquiring skills in psychophysical and electromyographic techniques. The PI is an Instructor in the Department of Rehabilitation Medicine which is strongly committed to supporting research in this field. The Mount Sinai School of Medicine and Teachers College provide a rich environment to enable the PI to become an independent investigator studying the mechanisms of recoveryafter stroke, and to translate research in motor control into therapeutic protocols for the rehabilitation of voluntary motor functions after brain injury.