Interhemispheric transfer of grasp control after stroke

偏瘫是中风后最常见的运动障碍，常导致持续性手 功能障碍长期目标是了解手运动恢复的机制 脑卒中后的功能，为临床实践中使用的康复方案提供科学依据。的 具体的假设是，非受累手可以帮助受累手的恢复。我们立足 这一假设是基于观察到先前用非参与手抓握改善了预期的 部分受试者脑卒中后患手对物体重量的抓握规划。基于这些 观察，本提案的重点是调查信息的类型和性质 大脑半球，通过事先操纵与非参与的手，以改善计划和执行 卒中后轻偏瘫患者和年龄匹配的对照者用受累手抓握。的 具体目标是：（1）调查来自肌肉传感器或触觉传感器的与体重相关的信息是否 来自指尖的信息介导了预期控制向双手物体重量的转移;（2） 检查双手之间预期控制转移的体重相关信息是否需要任务- 特定的肌肉活动;（3）确定先前是否使用未涉及的手进行操作 改善了相关手抓握的时间和空间神经肌肉控制。心理物理 将使用抓握工具的方法来检查规划所需的信息类型， 抓取和定量肌电图将用于调查非参与的贡献 手在改善神经肌肉控制的把握在涉及的手。该项目是作为一项 职业发展计划，以获得系统神经科学，运动控制和运动方面的培训 生物力学，同时获得心理物理和肌电图技术的技能。PI是一个 康复医学系的讲师，该系致力于支持以下领域的研究： 该领域西奈山医学院和师范学院提供了丰富的环境，使 PI成为研究卒中后恢复机制的独立研究者， 将运动控制研究转化为自主运动康复的治疗方案 脑损伤后的功能

Hemiparesis is the most commonmotor impairment after stroke that frequently results in persistent hand dysfunction. The long-term goal is to understand the mechanisms underlying the recovery of hand motor function after stroke to provide a scientific rationale for rehabilitation protocols used in clinical practice. The specific hypothesis is that the non-involved hand can assist in the recoveryof the involved hand. We base this hypothesis on the observation that prior grasping with the non-involved hand improved anticipatory planning of grasp to object weight with the involved hand in some subjects after stroke. Based on these observations, the focus of this proposal is to investigate the type and nature of information relayedacross the hemispheres, by prior manipulation with the non-involved hand, to improve planning and execution of grasp with the involved hand in patients with post-stroke hemiparesis and age-matched controls. The specific aims are to: (1) Investigate whether weight-related information from muscle sensors or tactile information from the fingertips mediates the transfer of anticipatory control to object weight across hands; (2) Examine whether weight-related information for transfer of anticipatory control across hands requires task- specific muscular activity; and (3) Determine whether prior manipulation with the non-involved hand improves the temporal and spatial neuromuscular control of grasping with the involved hand. Psychophysical methods using a grip instrument will be used to examine the type of information necessary for planning of grasp, and quantitative electromyography will be used to investigate the contribution of the non-involved hand in improving neuromuscular control of grasp in the involved hand. This project is proposed as part of a career development plan to obtain training in systemsneuroscience, motor control, andmovement biomechanics, while acquiring skills in psychophysical and electromyographic techniques. The PI is an Instructor in the Department of Rehabilitation Medicine which is strongly committed to supporting research in this field. The Mount Sinai School of Medicine and Teachers College provide a rich environment to enable the PI to become an independent investigator studying the mechanisms of recoveryafter stroke, and to translate research in motor control into therapeutic protocols for the rehabilitation of voluntary motor functions after brain injury.